Yeast beta-glucan ndeye inoshanda polysaccharide inotorwa kubva musero madziro embiriso. Muna 1941, Dr. Pillemer vakawana chinhu muyeast cell wall chinowedzera hutachiona. Muna 1961 Riggi akacherechedza ichi chinoshandiswa mumbiriso glycan se beta-glucan [1]. Zvakajairwa zvinyorwa zvebeta-glucan zvakare zvinosanganisira oats, fungi, gungwa regungwa, nezvimwewo, nekuti muviri haugone kugadzira kana kuburitsa beta-glucan pachayo, inofanirwa kuwedzerwa nenyika yekunze.

Kuwedzera kune β-glucan uye mbiriso sero madziro kune zvakare inonyungudika mvura mannose uye shoma shoma yechitin, β-glucan inoverengera 30% kusvika 60% yehuremu hwakaoma hwesero madziro, mukati memukati mesero madziro, ndeeiyo structural polysaccharide, iyo huru yemuviri basa nderekuchengeta sero remukati, kuchengetedza sero mechanical. Misaki et al. akawana kuti chimiro cheyeast β-glucan inonyanya kuumbwa ne β-1, 3-bond, uye ine chimwe chikamu che β-1, 6-chisungo chakasara.

Iyo immunomodulatory efficacy yeyeast beta-glucan inoenderana nekunanga kwayo, kugona kwayo kusunga kune chaiwo mareceptor pamusoro pemasero edziviriro, uku ichiwedzera phagocytosis chiitiko che macrophages. Iyi nzira inokurumidza kukwenenzvera mhinduro yemuviri uye inochengetedza chiyero chakakwana chesimba rekudzivirira.

Beta-glucan inoshanda zvikuru nekusunga kune matatu beta-glucan receptor marudzi [4]: ??(1) Dectin-1 receptor; (2) CR3; (3) Mamwe ma receptors, anosanganisira scavenger receptor uye LacCer. Kana mbiriso β-glucan ichipinda mumuviri wemunhu uye inosunga kune receptor, ichawedzera phosphorylation yeiyo intracellular immune receptor tyrosine motif (ITAM) uye Syk, uye inomisa iyo PI3K / Akt nzira, iyo inozopedzisira yatungamira kune phagocytosis, microbial kufa uye cytokine kuburitswa, kuitira kudzivirira zvirinani kusabvisa hutachiona hwekunze masero. Uye ipapo iwe unowana mhedzisiro yeimmunity.

Kubatsira kwehutano hweganda beta-glucan kunonyanya kuratidzwa mune zvinotevera zvinhu [6]:

1) Antioxidant simba: β-glucan ine antioxidant properties, iyo inogona kudzivisa chizvarwa che superoxides uye mamwe maitiro e-oxygen anogadzirisa (ROS) uye kuderedza kukuvadzwa kwekushungurudzika kweoxidative paganda.

2) Moisturizing effect: Nehuremu hwayo hwepamusoro, β-glucan ine simba rakasimba rekubatanidza mvura, iyo inogona kunyatsobatanidza mamorekuru emvura pamusoro pemasero eganda, kudzivirira kubuda kwemvura, uye kuderedza kurasikirwa kwemvura kuburikidza ne epidermis (TEWL). Mukuwedzera, inoumba firimu inodzivirira pamusoro peganda, inobatsira kuchengetedza unyoro uye kunyorova kweganda.

3) Ganda kugadzirisa uye kuporesa kugona: Seo et al. vakawana kuti zvakasiyana-siyana zve beta-glucan zvinogona kukurudzira kutama kwevanhu keratinocytes (HaCaT) uye ganda revanhu fibroblasts (HDFa), uye kukurumidza kuvhara maronda uye re-epithelialization mumakonzo emhando [7]. Uye zvakare, iyo inorwisa-kuzvimba uye inopesana-inogumbura zvimiro zve beta-glucan inobatsira kubvisa kuzvimba nekutsvuka uye kunyaradza ganda rakatsamwa. Chidzidzo muJournal of Therapeutic Dermatology chakaratidza kuti beta-glucan inobatsira pakurapa mild atopic dermatitis (eczema) [8].

4) Anti-kuchembera mhedzisiro: Beta-glucan inobatsira kuderedza zviratidzo zvekuchembera kweganda, senge makwinya uye kudonha. Inosimudzira synthesis ye collagen uye mamwe ganda extracellular matrix (ECM) zvikamu, kuwedzera ukobvu uye elasticity yeganda.

Mukuwedzera, beta-glucan inewo basa rekugadzirisa maruva emukati, kuderedza cholesterol, anti-kuneta, hutano hwemapfupa nezvimwe zvakadaro.

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