1.1 Laga soo bilaabo hagaajinta xuubka unugyada ilaa habaynta cerebrovascular

Maaddaama Citicoline markii ugu horreysay ay soo saartay Takeda Pharmaceutical ee Japan 1956, taariikhdeeda codsi waxaa loo arki karaa inay tahay taariikhda cusboonaysiinta garashada:

• 1980-yadii:Kaliya loo isticmaalo wakiilka hagaajinta xuubka unugga ka dib istaroogga

• 2010-yadii:Waxaa la ogaaday in ay kordhin karto dhiig-karka dhiigga maskaxda (PET-CT waxay muujisay koror 23% ah socodka dhiigga lobe ee ku meel gaarka ah)

• 2024,NIH ee Mareykanka waxay ku taxay inay tahay walax sharciyeed oo muhiim ah "isku-xidhka neerfaha"

1.2 Kobaca qarxa ee suuqa caalamiga ah

Marka loo eego xogta Qiimaynta Pharma:

Iibka caalamiga ah wuxuu gaadhay 4.7 bilyan US dollar sanadka 2024 (CAGR 12.3%)

Isticmaalka daroogada ee cusbitaalada muunada ee Shiinaha ayaa kordhay 400% saddex sano gudahood

Tilmaamaha waxaa lagu ballaariyay:

Waallida xididdada dhiigga (dhibcaha MMSE waxaa lagu hagaajiyay 2.1 dhibcood)

Dhaawac maskaxeed oo naxdin leh (Miisaanka saadaalinta GOS ayaa kordhay 1.5 darajooyin)

Cutubka Labaad: Dildilaaca Sanduuqa Madow ee Habka Ficilka

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2.1 Dariiqyo hawleed saddex-laab ah

Heerka caddaynta saamaynta bartilmaameedka: Isku-darka Phosphatidylcholine wuxuu hagaajiyaa daacadnimada xuubka neerfaha Heerka I: Horudhaca Acetylcholine wuxuu xoojiyaa gudbinta neurotransmitter Class II: Nidaaminta nitric oxide synthase waxay hagaajinaysaa ballaarinta microvascular (dhexroorka 18%) Heerka IIB

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2.2 Muddada daaqadaha dahabka ee bukaan-socodka

Daraasad 2024 ah oo uu sameeyay Isbitaalka Koowaad ee Jaamacadda Sun Yat-sen ayaa muujineysa:

Cirbadda xididka ee 1000mg 6 saacadood gudahood ka dib wadida xuubka maskaxda waxay badbaadin kartaa aagga penumbra ischemic ilaa 7.2cm3

Si kastaba ha ahaatee, ma jirin farqi weyn oo la taaban karo markii maamulku dhaafiyay 72 saacadood (p=0.34).

Cutubka Saddexaad: Muranka Muranka

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3.1 Shakiga ku saabsan ansaxnimada

Tilmaamaha UK NICE: Waxaa loo arkaa in caddaynta jirta aysan ku filnayn inay taageerto caymiska caafimaadka (qiimaha-wax-ku-oolnimada saamiga ￡45,000/QALY)

Lancet Neurology ** 2025 Meta-Alysis: Ma jiro farqi weyn oo u dhexeeya placebo ee kooxda daciifnimada garashada fudud (p=0.21)

3.2 Fowdada ku jirta Horumarinta Ganacsiga

Ogeysiinta Maamulka Alaabta Caafimaadka Qaranka ee 2024:

Laba iyo toban shirkadood ayaa buunbuuniyay tilmaamayaasha (kor u qaadaya "daaweynta adjuvant" sida "dib u noqoshada waallida")

Tijaabooyin lagu sameeyay goob ganacsi e-ganacsi gaar ah ayaa muujinaya in nuxurka dhabta ah ee 32% ee diyaarinta afka ay ka yar tahay 70% lacagta la calaamadeeyay.

Cutubka Afraad: Xudduudaha Horumarka Farsamada

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4.1 Nidaamka keenista dawooyinka cusub

Caqabadda maskaxda-maskaxda ee gelaysa liposomes peptide modified (Patent of Peking Team Team, CN202410123456.7)

Microneedles-ka jawaab celin ah oo joogto ah (Tijaabooyin xayawaan ah oo lagu sameeyay Jaamacadda Qaranka ee Seoul ee Kuuriyada Koonfureed ayaa muujinaya koror saddex laab ah oo noolaha)

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4.2 Waaberigii Daawada Shakhsi ahaaneed

Baadhista wadajirka ah ee Bgi waxay ogaatay in:

Saamaynta daawada ee CDP-cholinesterase gene polymorphic (la xisaabtanka 31% ee dadweynaha Aasiya) ayaa kordhay 47%

Cutubka Shanaad Xogta Bukaan-socodka-Adduunka Dhabta Ah

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5.1 Kiisaska ka faa'iidaystayaasha

Diiwaanka cisbitaalka sare ee Hangzhou: Ka dib daawaynta la isku daray, awoodda kaydinta qulqulka dhiigga maskaxda ee bukaan 62 jir ah oo qaba xanuunka maskaxda ayaa ka soo kabsaday 32% ilaa 89%

5.2 Is-sheegga xisbiga aan ansax ahayn

" Qaadashada nus sano oo joogto ah, kharashka bishiiba ee 300 yuan wuxuu keenay calool xanuun" - rikoodhka wareysiga Ms. Li, bukaan ka yimid Beijing