Lycopene (LYC), carotenoid, waa midabka dufanka leh, inta badan laga helo yaanyada, qaraha, canabka iyo miraha kale, waa midabka ugu weyn ee yaanyada bislaada. Lycopene waxay leedahay faa'iidooyin caafimaad oo kala duwan, oo ay ku jiraan xoqida xagjirnimada xorta ah, yaraynta bararka, nidaaminta gulukooska iyo dheef-shiid kiimikaadka, iyo saamaynta neuroprotective.

Dhawaan, Cilmi-baarayaal ka socda Jaamacadda Caafimaadka ee Shanxi ayaa daabacay warqad ku jirta joornaalka Redox Biology oo cinwaankeedu yahay "Lycopene waxay yaraynaysaa yaraanta garashada da'da ee la xiriirta iyada oo la kicinayo maskaxda beerka. Warqad cilmi baaris ah oo ah koritaanka fibroblast factor factor-21 signaling ".

Daraasaduhu waxay muujiyeen in kabidda lycopene ee bilaha 3 ay dib u dhigi karto gabowga maskaxda ee jiirarka iyo yaraynta dhaawaca garashada ee da'da, iyo lycopene waxay hagaajisaa xumaanshaha neerfaha, cilladda mitochondrial, dhaawaca synaptic, waxayna kor u qaadaa isku-dhafka synaptik ee jiirarka gabowga.

Intaa waxaa dheer, lycopene waxay kicisay dhidibka beerka-maskaxda FGF21 calaamadaynta jiirarka gabowga, taas oo kor u qaadeysa sii deynta neurotransmitters iyada oo la kordhinayo heerarka ATP ee mitochondrial iyo kor u qaadida fiyuuska vesicular synaptic. Tani waxay soo jeedinaysaa in FGF21 laga yaabo inay noqoto bartilmaameedka daaweynta ee xeeladaha faragelinta nafaqeynta si loo daahiyo gabowga maskaxda loona wanaajiyo garashada la xiriirta da'da.

Da'da, gabowga maskaxda, cilladda mitochondrial waa mid ka mid ah qodobbada ugu muhiimsan, cilmi-baarayaashu waxay ogaadeen in kabitaannada lycopene ay hagaajin karaan waxyeelada mitochondrial morphological, iyo inay beddelaan heerka silsiladda gaadiidka elektaroonigga ah ee mitochondrial oo ay sababtay gabowga, kor u qaadista wax soo saarka ATP, taas oo muujinaysa in lycopene ay leedahay saameyn difaac ah oo ku saabsan shaqada mitochondrial.

Ugu dambeyntii, cilmi-baarayaashu waxay sidoo kale sameeyeen tijaabooyinka vitro waxayna ogaadeen in lycopene ay xoojisay awoodda unugyada beerka si ay u taageeraan neurons, oo ay ku jiraan hagaajinta gabowga unugyada, kor u qaadista shaqada mitochondrial, iyo kordhinta dhererka axon neuron.

Isku soo wada duuboo, natiijadu waxay soo jeedinaysaa in kabitaannada lycopene ay dib u dhigi karto gabowga maskaxda oo ay ka hortagto naafanimada garashada ee da'da ee jiirarka, qayb ahaan sababtoo ah lycopene waxay ka shaqeysaa dhidibka hepato-maskaxda FGF21, taasoo soo jeedinaysa in FGF21 ay noqon karto bartilmaameedka daweynta ee suurtagalka ah ee waxqabadyada nafaqada si loo hagaajiyo cudurrada garaadka ee la xiriira da'da neurodegair.