Citicolineayaa si weyn loogu isticmaalay waxqabadka kiliinikada, inta badan daawaynta daba-galka neerfaha ee ay sababto dhaawaca craniocerebral ama shilalka maskaxda, waxaana uu helay adeegsiyo cusub oo ku saabsan waxqabadka kiliinikada. Daawaynta dhiig-baxa maskaxda, cudurka Parkinson, glaucoma, sonkorowga neuropathy peripheral neuropathy iyo tinnitus iyo cudurrada kale ayaa sidoo kale soo jiitay dareenka sii kordhaya. Haddaba waa maxay citicoline, waa maxay saamaynta dawooyinka, tilmaameheeda (daawaynta gaarka ah ee cudurada), waxtarka iyo badbaadada?

Citicoline waa hal nucleotide oo ka kooban ribose, cytosine, pyrophosphate iyo choline. Waa nucleotide endogenous ee jirka aadanaha. Waxay ku lug leedahay wadooyin badan oo dheef-shiid kiimikaad oo muhiim ah oo jirka ah. Waa horudhaca dabiiciga ah ee fosfolipid synthesis ee qaab dhismeedka xuubka unugyada neerfaha iyo horudhaca biosynthesis ee neurotransmitter acetylcholine.

Citicoline waa wakiilka neuroprotective kaas oo ilaalin kara neerfayaasha nugul, si loo yareeyo ama looga hortago horumarka cudurka. Waqtigan xaadirka ah, wakiilada neuroprotective ee sida caadiga ah loo isticmaalo waxqabadka kiliinikada waxaa ka mid ah xannibayaasha kanaalka calcium, glutamate antagonists, scavengers xagjirka bilaashka ah, iyo xasiliyeyaasha xuubka unugyada, kuwaas oo citicoline ay iska leedahay xasiliyeyaasha xuubka unugyada.

Citicolinewaxay leedahay saameyno farmaajo oo badan oo bartilmaameed ah, hababka ficilkan ayaa ka dhigaya inay leeyihiin awood weyn oo ku saabsan ilaalinta neuroprotection iyo hagaajinta dareemayaasha. Waxay leedahay saameyn neuroprotection ah oo xannibaya dhacdada dhaawaca neerfaha iyo saameynta hagaajinta dareemayaasha ka dib marka ay dhacdo dhaawaca neerfaha, taas oo ballaarisa daaqada wakhtiga daaweynta ee citicoline.

Iyada oo ku saleysan sifooyinka dawooyinka, citicoline waxaa si weyn loogu isticmaalaa daaweynta istaroogga, garashada garashada, dhaawaca maskaxda, cudurka Parkinson, glaucoma, neeropathy peripheral neuropathy, tinnitus iyo cudurrada kale, iyo waxtarkeeda iyo badbaadada ayaa lagu xaqiijiyay daraasado caafimaad oo badan, oo leh caddayn caafimaad oo ku filan. Stroke: Istaroog waa nooc ka mid ah xididdada dhiigga ee maskaxda oo xirma ama dillaaca, taasoo keenta dhaawac maskaxda ah oo ka mid ah qaybaha cudurrada, oo ay ku jiraan ischaemic iyo dhiigbaxa dhiigbaxa, kuwaas oo ischaemic stroke waa nooca ugu muhiimsan ee istaroogga, oo ka dhigan 75% ilaa 90% dhammaan istaroogga. Khatarta nolosha ee istaroogga ee dadkeenna waa 35%-40.9%, kaalinta koowaad ee adduunka, ma aha taas oo keliya, istaroogga sidoo kale waa sababta ugu horreysa ee dhimashada iyo naafanimada ee dadka deggan.

Caddaynta cilmi-baaris caafimaad:

1. Sannadkii 2002, Jariidada American Stroke waxay daabacday falanqayn-meta-falanqaynta tijaabooyinka bukaan-socodka ee bukaannada qaba istaroogga ba'an ee ischaemic, taas oo muujisay in citicoline-ka afka laga qaato ay kordhisay suurtagalnimada bukaannada istaroogga ka soo kabanaya ka dib 3 bilood [1].

2. 2009, tijaabo cilmi baaris ah oo kormeerka daroogada ah ayaa lagu sameeyay South Korea bukaanada 4191 ee qaba istaroogga degdega ah ee ischaemic, natiijadu waxay muujisay in citicoline ay hagaajisay dhibcaha NIHSS iyo dhibcaha BI ee bukaanada leh faa'iidooyinka daaweynta hore iyo dambe, iyo faa'iidooyinka codsiga muddada dheer ayaa ahaa mid weyn, iyo saameynta daweynta ayaa si togan ula xiriirta qiyaasta. Horumarku wuxuu ahaa mid aad muhiim u ah kooxda qiyaasta sare leh (≧2000mg/maalintii), iyo codsiga muddada-dheer wuxuu ahaa mid badbaado leh oo loo dulqaatay [2].

3. Natiijooyinka xarun-badan, randomized, laba-indho la'aan, daraasad tijaabo tijaabo ah oo la xakameeyey oo ku saabsan dhiig-baxa maskaxda waxay soo jeedinaysaa in citicoline ay tahay daawo badbaado leh oo loogu talagalay daaweynta dhiigbaxa maskaxda oo leh saameyn daweyn oo togan [3].

4. Summada furan, kala-soocidda, daraasad isbarbar-dhig ah ayaa qiimeysay saameynta citicoline ee cilladda garashada ee istaroogga ka dib, natiijadu waxay muujisay in isticmaalka muddada dheer ee citicoline ay si weyn u wanaajisay garashada garaadka ka dib-stroke [4].