SAIB (sucrose isobutyrate acetate) waa faa'iidooyin badan oo faa'iido leh oo dawada ah. Waa dareere viscous ah oo lagu diyaariyay esterification la kontoroolo ee sonkorta dabiiciga ah (sukrose) oo leh acetic acid iyo isobutyric anhydride. Waa isku dhafka ay soo saarto nadiifinta iyo wax soo saarka si heer sare ah loo sifeeyay. Waxa loo isticmaali karaa walxo sii dayn joogto ah, dareere/sidee iyo horjooge xadgudubka daroogada.

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Tilmaamaha alaabta SAIB

SAIB waa dareere/qaade aad u wanaagsan oo loogu talagalay hydrophobic API wuxuuna leeyahay shaqo sii dayn gaabis ah.

SAIB ma dhalaaliso oo waxay ahaanaysaa amorphous heerkulka qolka, taas oo si weyn kor ugu qaada heerka joogtada ah ee gaarsiinta daroogada;

SAIB waa non-polymeric oo ma xinjiroobin ama soo dagdagto marka la taabto dareerayaasha jirka ee aqueous. SAIB waxay ku milmaysaa dareerayaal badan oo dabiici ah waxayna la jaan qaadayaan walxo badan; SAIB waxaa lagu kala firdhi karaa biyaha iyadoo la kaashanayo dareerayaasha organic.

SAIB waxay leedahay sifooyin bioadhesive waxaana loo isticmaali karaa codsiyada balaastigga, sublingual iyo buccal.

Codsiga alaabta

1. Dib u dhigista sii deynta

Jaantuska kore, waxaa laga arki karaa in SAIB uu leeyahay qiimo HLB ah oo ku saabsan 5, taas oo muujinaysa in ay tahay hydrophobic

2. Biyo liidata xal API

Hydrophobic SAIB waa dareere/ side wanaagsan API leh biyo milmayn liidata, iyo isticmaalka SAIB waxa ay wanaajisaa milanka dawooyinka ganacsi ahaan la milmi karin.

3. Ka hortag xadgudubka daroogada

Isticmaalka SAIB waxay kordhisaa xajmiga walxaha opioids inta lagu jiro shiidada waxayna faragelisaa soo saarista daroogada.

(1) Polymers (polyoxyethylene iyo/ama hydroxypropyl methylcellulose) iyo tocopherol acetate waa granules laga sameeyay xal alkohol ah ee SAIB. Diyaargarawga waxa loo kala saaray mid aan la daawayn/aan la dawayn ama kulayl la daweeyay/la daaweeyay (la daaweeyay 90oC 30 daqiiqo).

(2) Pseudoephedrine hydrochloride, polymers (polyoxyethylene iyo/ama hydroxypropyl methylcellulose) iyo tocopherol acetate waa granules laga sameeyay xal aalkolo ah ee SAIB. Diyaargarawga waxa loo kala saaray mid aan la daawayn/aan la dawayn ama kulayl la daweeyay/la daaweeyay (la daaweeyay 90oC 30 daqiiqo).

Qiimaynta xadgudubka sanka ayaa muujisay in isticmaalka SAIB ay kordhisay cabbirka budada wakhtiga shiida, iyada oo ilaa 47% cabbirka budada shiida ay ka weyn tahay 1mm.

Marka la barbardhigo kooxda kantaroolka, qadarka soo saarista SAIB ee biyaha, 0.1% N HCl iyo 0.1% N NaOH dareerayaasha ayaa hoos u dhacay 41.3% -42.5%, 24.8% -26.1% iyo 37.4% -50.6%, siday u kala horreeyaan. Isticmaalka dareerayaasha organic-ga ah ee soo saarista waxay soo saartaa hadhaaga dhegdheg ee ay adagtahay in la maro dariiqyada kala duwan ee maamulka (tusaale, duritaanka, nuugista, khuurada, iwm.), ka hortagga xadgudubka daroogada

gunaanad

Isticmaalka SAIB, iyada oo aan dahaar lahayn, ayaa si toos ah loogu qasi karaa API si loo sii daayo daroogada loona gaaro sii deyn joogto ah.

Hydrophobic SAIB, kaas oo lagu kala firdhi karo biyaha iyadoo la kaashanayo dareerayaasha organic, waxaa loo isticmaali karaa apis hydrophobic ama hydrophilic; SAIB waxay wanaajin kartaa milanka API-ga oo leh milmi-biyood liidata waana dareere aad u fiican iyo sidayaal API oo leh milmi-biyood liita.

Isticmaalka SAIB waxay ka hortagtaa xadgudubka mukhaadaraadka iyadoo kordhinaysa xajmiga walxaha dawada marka dhulka la dhigo, faragelinta soo saarista maandooriyaha, iyo adkaynta in daawada lagu nuugo iyada oo loo marayo habab kala duwan oo maamulka ah.

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