Youdaoplaceholder0 1.1 Sixirka jireed ee isjiidjiidka viscosity: Isbeddelka saddex-geesoodka ah ee caloosha oo loo beddelo xiidanka

Qaab dhismeedka molecular ee polyglucose waxa uu ka kooban yahay hadhaaga gulukoosta ee isku xidha bakhtiyaanasiibka, iyo qaabkan gaarka ah waxa uu ku siinayaa sifooyin rheological gaar ah. Deegaanka aadka u acidic ah ee caloosha (pH 1.5-3.5), silsiladaheeda molecular waxay si degdeg ah u sameeyaan qaab-dhismeedka shabakad saddex-geesood ah iyada oo loo marayo bonds hydrogen, iyo viscosity isla markiiba wuxuu kordhiyaa 1200 mPa·s (qiyaastii laba jeer tan malab), si wax ku ool ah dib u dhigista heerka faaruqinta caloosha ilaa 40% iyo dheeraynta dareenka buuxda Ka dib marka la soo galo mindhicirka yar, marka qiimaha pH uu kor u kaco ilaa 6.0-7.5, qaar ka mid ah curaarta hydrogen-ka ayaa jebiya oo viscosity-ku wuxuu hoos ugu dhacayaa 300-500 mPa·s. Si xad dhaaf ah ugama hor istaagayso nuugista nafaqeynta mana ku darto asiidhyada bile si loo yareeyo heerka nuugista kolestaroolka. Marka la gaaro mindhicirka, hoos ficilka halsano microbial, viscosity dheeraad ah hoos u 50 mPa·s, sii daayo asiidh dufan ah silsilad gaaban (SCFAs) si ay u bixiyaan tamar probiotics (Jaantuska 1).

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Taageerada xogta Youdaoplaceholder0:

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Heerka daahitaanka faaruqinta caloosha: 40% (Cuntada Hydrocolloids 2022, n=30)

Heerka ka-hortagga nuugista kolestaroolka: 22% (xogta shahaadada GRAS ee US FDA)

Kordhinta wax soo saarka SCFAs: Isku-ururinta acetic acid Colonic ayaa kordhay 3.8 jeer (Gut 2023, Qaabka Xayawaanka)

Youdaoplaceholder0 1.2 "quudinta saxda ah" ee istiraatijiyadda microbiome

Xeerarka viscosity ee polydextrose ma aha oo kaliya inay saameeyaan habka dheefshiidka jirka, laakiin sidoo kale waxay sameeyaan isdhexgalka firfircoon ee dhirta mindhicirka. Xaaladda viscosity-ka sare waxay samaysaa xannibaad jidheed xiidanka u dhow, taasoo yaraynaysa xidhiidhka ka dhexeeya bakteeriyada cudur-sidaha iyo xuubka xiidmaha. Maaddaama maqaarku hoos u dhaco, waxay si tartiib tartiib ah isu beddeshaa substrate khamiir leh, iyada oo doorbidaysa kicinta fidinta Bifidobacteria iyo bakteeriyada lactic acid. Koox ka socota Jaamacadda Cambridge waxay ogaadeen iyada oo loo marayo taxanaha metagenomic in qaadashada joogtada ah ee 12g/maalintii polydextrose ee 8 toddobaad ay kor u qaadi karto saamiga F/B ee Thick-miliae/Bacteroidates ilaa 1.3 Saamayntan laba-geesoodka ah ee "difaaca marka hore, ka dibna nafaqada" waxay si fiican u daboolaysaa baahiyaha deegaanka ee qaybaha kala duwan ee mareenka mindhicirka.

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Youdaoplaceholder0 Cutubka 2 Codsiga Muuqaalka Kacaanka: Soo Galitaanka Xudduudaha laga bilaabo Cuntooyinka lagu xakameeyo Sonkorta ilaa Nafaqada ICU

Youdaoplaceholder0 2.1 Warshadaha Cuntada: "qalfoofka aan la arki karin" ee alaabooyinka GI hooseeya

Goobta dubista, awoodda sare ee haynta biyaha (> 8g biyaha / g) iyo xasiloonida kulaylka (dulqaadka 200 ℃) ee polyglucose ayaa ka dhigaya beddelka ugu habboon ee sukrose. "Kukiyada Sonkorta eber" ee ay bilaabeen kooxda Meiji ee Japan waxay isticmaalaan polyglucose sida fiber-ka xudunta u ah, iyagoo gaaraya 1.2g oo ah karbohaydraytyada saafiga ah buskudkiiba, iyo dhadhanka iyo qallafsanaantu kama duwana kuwa alaabta sonkorta ku jirta. Waxa ka sii muhiimsan, nidaaminteeda viscosity ee mindhicirka yar waxa ay dib u dhigi kartaa nuugista gulukooska oo waxa ay hoos u dhigtaa gulukoosta dhiiga ee ka dib 34% (xogta kiliinikada ee Daryeelka Sonkorowga 2021).

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Youdaoplaceholder0 Kiis cusub:

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Youdaoplaceholder0 Nestle : The "Smart qunyar-sii-daynta tamarta bar tamarta" oo lagu sameeyay isku dhafka polydextrose iyo dextrin adkeysi leh ayaa leh naqshad jilicsanaanta viscosity taasoo kordhisa nuugista karbohaydrayt ilaa 6 saacadood, buuxinta baahida tamarta joogtada ah ee orodyahannada marathon.

Youdaoplaceholder0 Nongfu Spring : Waxaa la bilaabay "Biyaha ifaya ee xiidmaha" oo lagu daray polyglucose, kaas oo isticmaala hantidiisa halsano ee yar yar si uu u soo saaro gaas khafiif ah xiidanka si uu u kiciyo peristalsis xiidmaha. Waxay iibisay in ka badan 100 milyan oo dhalo saddex bilood gudahood.

Youdaoplaceholder0 2.2 Nafaqada caafimaadka: "Ilaaliyaha xannibaadda mindhicirka" ee bukaannada ICU

Caqabadda xuubabka mindhicirka ee bukaanada aadka u xanuunsan ayaa badanaa keena caabuqyo habaysan. Tijaabo aan kala sooc lahayn oo la kontorooliyay (n=158) oo ay samaysay Cisbitaalka Koowaad ee Jaamacadda Zhejiang ayaa muujisay in bukaannada ICU ee lagu kabay 15g ee polyglucose maalin kasta ay 42% hoos u dhaceen dhacdooyinka endotoxemia iyo 29% hoos u dhac ku yimid tusaha qulqulka mindhicirka (plasma ligonin). Farsamaynta waxay ku jirtaa in xaaladda sare ee viscosity ay sameyso filim ilaalin ah caloosha, taas oo yaraynaysa khatarta boogaha diiqada. Aashitada butyric ee ay sii daysay qaybta xiidanka waxay si toos ah u kor u qaadaa dhumucda lakabka xabka (kordhinta tirada unugyada gobletka 37%), taasoo gaadhaysa xoojinta xayndaabka jireed iyo kiimikaad.

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Youdaoplaceholder0 Cutubka 3 Horumarka Tignoolajiyada: Ka cusboonaysiinta 'Qaababka Waxqabadka' ilaa' Nafaqada Xisaabinta '?

Youdaoplaceholder0 3.1 Nidaaminta saxda ah ee wax ka beddelka molecular

Kala duwanaanshaha jawaabta viscosity ee polydextrose-dhaqameedku waa xaddidan yahay, taas oo adkeynaysa in si sax ah loo waafajiyo baahiyaha gaarka ah. Bishii Juun 2023, DSM ee Nederlaan waxay ku dhawaaqday tignoolajiyadeeda rukhsadda leh "PolySmart ?", kaas oo soo saaray saddex nooc oo qalooca viscosity iyada oo la xakameynayo heerka polymerization (qiimaha DP) ee gulukooska iyo sorbitol:

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Youdaoplaceholder0 G nooca ? (kor u qaadida caloosha): Viscosity ilaa 1500 mPa·s at pH

Youdaoplaceholder0 C nooca (colon- targeted): Viscosity si aad ah ayuu hoos ugu dhacaa ilaa 30mPa·s pH> 6.5, door biday dadka calool istaagga leh;

Youdaoplaceholder0 Nooca B (qaab dheellitiran): Kala-guur fudud oo wadarta viscosity mindhicirka, ku habboon maaraynta gulukoosta dhiigga ee bukaanka sonkorowga qaba.

Youdaoplaceholder0 3.2 Naqshadeynta qaabeynta ee ay caawisay AI

Qalabka "FiberEngine" ee ay soo saartay shirkadda Israel ee NutriAI waxay isku daraysaa xogta microbiota ee 2 milyan iyo moodooyinka dhaqdhaqaaqa dareeraha, kuwaas oo saadaalin kara qiyaasta ugu wanaagsan ee polydextrose ee da'aha kala duwan iyo xaaladaha cudur. Tusaale ahaan, bukaanada qaba IBS (Irritable Bowel Syndrome), nidaamku wuxuu ku talinayaa isku darka maalinlaha ah ee 8-10g oo polyglucose ah iyo 2g oo fructooligosaccharides ah, taas oo yareyneysa dhacdooyinka calool-istaagga caloosha 65% (2023 xogta la socodka isticmaalaha).

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Goobta-haystaha0 Cutubka 4-aad Qalalaasaha Warshadaha: "Badweynta Buluugga ah ee Fiber" ee Rafaa ay u tartamayaan

Youdaoplaceholder0 4.1 Awooda tartanka ayaa kor u kacaya

Cabbirka suuqa polydextrose ee caalamiga ah ayaa la filayaa inuu ka kordho 870 milyan US dollar sanadka 2023 ilaa 2.1 bilyan oo doolarka maraykanka ah 2030 (CAGR 12.3%). Shiinaha ayaa noqday goobta ugu weyn ee dagaalka.

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Youdaoplaceholder0 Baolingbao Bio : Maalgelinta 500 milyan yuan si loo ballaariyo 30,000 tan sanadkiiba xariiqda wax-soo-saarka, iyadoo la adeegsanayo habka enzymatic synthesis si loo gaaro 99.5% nadiif ah;

Youdaoplaceholder0 Rogate : Probiotic-polyglucose microcapsules oo la sameeyay iyadoo lala kaashanayo CHR. Hansen wuxuu kordhiyey heerka badbaadada u adkaysiga aashitada ilaa 90%;

Youdaoplaceholder0 Matsuya Chemie, Japan : Soo bandhigay "nano-fibrotic polyglucose," kaas oo leh saddex jeer dareenka sharciyeynta viscosity oo ay FDA siisay calaamadda daawada agoonta ee loogu talagalay cilladda mindhicirka gaaban.

Youdaoplaceholder0 4.2 Caqabado laba geesood ah oo sharciyeed iyo garashada

Inkasta oo polydextrose loo ansixiyay sida fiber-cunto oo ay soo saartay Midowga Yurub, Shiinaha iyo dalal kale, macaamiisha ayaa weli leh isfaham la'aan. Sahan ay samaysay FMCG gudaha Maraykanka ayaa muujisay in kaliya 28% macaamiisha ay si sax ah u kala saari karaan faraqa u dhexeeya polydextrose iyo istaarijka adkaysiga leh. Si ka sii daran, qaadashada xad-dhaafka ah (> 50g/maalintii) waxay keeni kartaa calool-xanuun ama faragelin nuugista macdanta. Warshaduhu waxay si degdeg ah ugu baahan yihiin inay dejiyaan habraacyada qiyaasta qiyaasta.

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Youdaoplaceholder0 Cutubka 5 Horaad u eega: "Shabakadda Fiber" ee GUT ilaa Caafimaadka Jirka

Youdaoplaceholder0 5.1 Caddeyn cusub oo loogu talagalay habaynta dhidibka maskaxda-mindhicirka

Horraantii 2024, Machadka Tiknoolajiyada ee California wuxuu tijaabiyey jiirka in butyric acid ay soo saartay halsano polydextrose ay kicin karto neerfaha hypothalamic iyada oo loo marayo neerfayaasha siilka, hoos u dhigista dabeecadaha walaaca u eg 43%. Tani waxay bixinaysaa sharaxaad heer-molecular ah sheegashada ah "cuntada faybarku ku badan yahay waxay hagaajisaa caafimaadka maskaxda".

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Youdaoplaceholder0 5.2 Hal-abuurnimada qaska ah ee bayoloji synthetic

Bilowga Maraykanka ee Zymergen waxa ay adeegsatay tignoolajiyada CRISPR si ay wax uga bedesho wadaadada Trichia, taas oo u sahlaysa in ay si toos ah u qariso "polyglucose hidde-edited" oo leh qalooca viscosity habaysan. Alaabtani waxay muujisay horumar 80% ah ee saxnaanta jawaabta pH ee tijaabooyinka dheefshiidka ee la ekayd waxaana la filayaa inay gasho marxaladda tijaabada caafimaad sanadka 2025.

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Youdaoplaceholder0 Gabagabo: Dib u qeexida "xuduudaha caqliga leh" ee Fiber ?

Saamaynta viscosity gradient ee polydextrose waxay calaamad u tahay waa cusub ee fiber-cuntada, kana guuraysa "kaabista dadban" una guurto "sharciga firfircoon". Marka qayb ka mid ah fiber-ku ay si madax-bannaan u habayn karto shaqadeeda iyada oo ka jawaabaysa jawiga dheef-shiid kiimikaadka, waxaa laga yaabaa inaan markhaati ka nahay isbeddelka isbeddelka ee sayniska nafaqada - waxqabadyada caafimaad ee mustaqbalka ma noqon doonaan dadaalka kali ah ee hal molecule, laakiin halkii qoob-ka-cayaarka ee qalabka casriga ah, microbiome, iyo sirdoonka macmal. Isagoo ku guuleystay abaalmarinta Nobel Prize ee Chemistry, Frances Arnold, ayaa mar yiri, "Moleekuleeyada dabiiciga ah waxay horey u haysteen fursado aan xadidneyn. Waxa aan u baahanahay inaan sameyno waa inaan baranaa inaan dhageysano 'luqadda wakhtiga iyo booska'."