teapolyphenols (TPs) waa erey guud oo loogu talagalay xeryahooda polyhydroxyphenolic ee shaaha, oo ay ku jiraan flavanols (catechins), flavandiols, flavonoids iyo phenolic acids. Catechins waa qayb ka mid ah walxaha muhiimka ah ee polyphenols shaaha, oo xisaabiya qiyaastii 60% ilaa 80% wadarta cadadka polyphenols shaaha. Waxay inta badan ka kooban yihiin 8 monomers, oo ay ku jiraan epigallocatechin gallate, epigallocatechin, gallocatechin, epicatechin gallate, epicatechin gallate, catechin gallate, epicatechin gallate, epicatechin gallate, epicatechin gallate, epicatechin gallate, epicatechin iyo epicatechin.

Habka diyaarinta shaaha, polyphenol oxidase iyo peroxidase oxidize catechins si loo helo thearubin, theaflavin iyo theaflavin saddex midab oo shaaha ah. TP-yadani kaliya maaha inay siiyaan shaaha dhadhankiisa iyo midabkiisa kakan, laakiin sidoo kale waxay faa'iido u leeyihiin caafimaadka aadanaha.

Maanta, iyadoo la raadinayo horumar dhaqaale oo tayo sare leh, dadku waxay sidoo kale tixgeliyaan horumarinta cagaaran iyo dib u warshadaynta. Polyphenols shaaha waxay leeyihiin antioxidant, bakteeriyada, kansarka ka hortagga iyo hawlaha ka hortagga buurnaanta, sidaas darteed cilmi-baarayaashu waxay u isticmaaleen daawada iyo cuntada.

Daawada, cilmi-baarayaashu waxay isticmaalayaan hababka dhalmada si ay u ilaaliyaan daawooyinka si sahlan loo baabi'in karo oo ay u wanaajiyaan bioavailability-kooda; Intaa waxaa dheer, polyphenols shaaha waxaa lagu daraa borotiinno iyo polysaccharides si ay u sameeyaan alaab cusub oo qorraxda iyo daawooyinka, kuwaas oo loo isticmaalo daryeelka maqaarka, ka-hortagga xasaasiyadda, ka-hortagga cudurada, ilaalinta caafimaadka afka iyo nidaaminta dheef-shiid kiimikaadka.

Dhinaca cilmi-baarista cuntada, polyphenols shaaha waxaa inta badan lagu daraa polysaccharides, borotiinno, iwm., iyada oo la adeegsanayo isdhexgalka molecules si loo hagaajiyo tayada dareenka cuntada, dheereynta muddada kaydinta cuntada, iyo samaynta alaabta baakadaha cuntada. Iyada oo taas ku saleysan, waxaan ka wada hadalnay cilmi-baarista codsiga polyphenols shaaha ee goobta cuntada iyo daawada, si aan u bixinno tixraaca cilmi-baarista qoto dheer ee polyphenols shaaha ee cuntada iyo daawada.

1. sifooyinka jirka iyo kiimikaad ee polyphenols shaaha

polyphenols shaaha waxaa laga soo qaatay caleenta shaaha oo waa isku dhafka ah xeryahooda polyhydroxyl organic, oo ay ku jiraan catechins, anthocyanins, flavonols iyo phenolic acids, iwm. Qaybta ugu weyn ee antioxidant waa catechin. Waxaa ka mid ah, Epigallocatechin gallate waxay u dhigantaa 50% ilaa 60%, Epicatechin gallate waxay u dhigantaa 15% ilaa 20%, epigallocatechin 10% ilaa 15%, gallatechin 6% ilaa 8% Heerkulka qolka, polyphenols shaaha waa budo huruud ah ama iftiin cagaaran, dhadhan astringent, caabbinta aashitada xooggan, xasilloon pH 2 ~ 7; polyphenols shaaha waxay leeyihiin hygroscopicity gaar ah oo ay fududahay in la beddelo midabka deegaanka alkaline.

2.waxqabadka nafleyda ee polyphenols shaaha

polyphenols shaaha waxay leeyihiin hawlo bayooloji oo kala duwan sida antioxidant, bakteeriyada iyo anti-mutation, EGCG waa tan ugu badan ee catekins waxayna ciyaaraan waxqabadka ugu weyn ee antioxidant. Dhaqdhaqaaqa bayoolojigu wuxuu ka yimaadaa kooxda phenolic hydroxyl ee shaaha polyphenols, kaas oo ciyaara waxqabadyo bayooloji oo kala duwan oo noocyo kala duwan ah. Hawlahan gaarka ah waxay sameeyaan polyphenols shaaha si weyn loogu isticmaalo cuntada.

Codsiga polyphenols shaaha ee cuntada

1. Ilaalinta iyo ilaalinta cuntada

Polyphenols shaaha ayaa si weyn loogu isticmaali karaa ilaalinta cuntada iyo ilaalinta, waxyeellooyinkeeda aan sunta ahayn iyo sifooyinka badbaadada la cuni karo ayaa ka dhigaya doorasho ku habboon. Waxay ka hortagi kartaa midabka oksaydhka cuntada, hagaajinta xasiloonida cellulose, iyo ilaalinta nafaqooyinka cuntada.

2.Beddel antioxidants synthetic

Iyadoo fiiro gaar ah la siinayo badbaadada cuntada, polyphenols shaaha ayaa si tartiib tartiib ah u beddelaya antioxidants macmal ah sida antioxidants dabiiciga ah. Looma isticmaali karo oo keliya saliidaha xoolaha iyo khudradda, hilibka hilibka, badeecadaha biyaha, khudradda iyo khudradda iwm, laakiin sidoo kale waxaa loo isticmaali karaa macmacaanka, nacnaca iyo wixii la mid ah. Waxaa xusid mudan in firfircoonida antioxidant ee polyphenols shaaha markii ugu horreysay loo adeegsaday dufanka iyo cuntooyinka saliidda leh. Sababtoo ah dhaqdhaqaaqa phenol hydroxyl ee giraanta benzene ee catechins si ay u siiso hydrogen, waxay leedahay awood yareyn xoog leh waxayna noqotaa antioxidant dabiici ah oo ku habboon dufanka.

Habka antioxidative ee polyphenols shaaha waa in kooxda firfircoon ee phenol hydroxyl, sida ku-deeqaha hydrogen, ay ku xirto kooxda xorta ah ee acids dufanka leh, waxay joojisaa falcelinta silsiladda ee oksaydhka dufanka, sidaas darteed waxay joojisaa samaynta hydroperoxide. Isla mar ahaantaana, polyphenols shaaha dufanku ku milma waxay ku daadin karaan walxaha birta ah ee doorsooma ee saliidda, si ay u lumiso dhaqdhaqaaqa kicinta waxayna joojisaa falcelinta silsiladda xagjirka ah ee xorta ah ee ka imanaysa isha. Intaa waxa dheer, kooxda phenol hydroxyl lafteeda ayaa si fudud u oksaydhaysan, taas oo yaraynaysa maaddada oksijiinta ee saliidda iyo dib u dhigista oksaydhka saliidda.

3.Kobcinta cuntada oo shaqaynaysa

Polyphenols shaaha ayaa muujinaya karti weyn oo ku saabsan horumarinta cuntada shaqeyneysa, iyo qaab dhismeedka kiimikada ee gaarka ah ayaa go'aaminaya in uu leeyahay awood xooggan oo uu ku saaro xagjirnimada xorta ah. Polyphenols shaaha waxay leeyihiin awood yar oo REDOX ah, kooxda polyo-phenol hydroxyl waxay ku siin kartaa hydrogen si ay u joojiso ama u joojiso falcelinta silsiladda xagjirka ah ee xorta ah, iyo qaab-dhismeedkeeda kiimikaad ee gaarka ah ayaa go'aaminaya in ay leedahay awood xooggan oo ay ku saarto xagjirnimada xorta ah. Polyphenols shaaha waxay dhaqaajin karaan nidaamka xoqidda ee xagjirrada xorta ah, waxayna joojinayaan soo saarista xagjirnimada xorta ah iyagoo joojinaya ion birta ku-meel-gaadhka ah ee oksaydhka ee nidaamka oxidase. Sida dabiiciga ah ee xagjirka ah ee dabiiciga ah, polyphenols shaaha ayaa faa'iido u leh ilaalinta caafimaadka aadanaha. Inkasta oo Shiinuhu uu weli ku jiro marxaladdan curdinka ah, wuxuu leeyahay rajooyin ballaaran oo horumarineed oo mustaqbalka ah.

4.Codsiga ilaalinta alaabta hilibka iyo alaabta biyaha

Bakteeriyada caamka ah ee ku jirta badeecooyinka hilibka waa pseudomonas, Enterobacter, staphylococcus iyo salmonella, bakteeriyada ugu badan ee keenta burburka alaabta biyaha waa bakteeriyada pseudomonas. Polyphenols shaaha ayaa si wax ku ool ah u xakameyn kara taranka bakteeriyada kala duwan, waxay hoos u dhigtaa oksaydhka dufanka, dib udhigista xumaanshaha, sidaas awgeed waxay kordhisaa cusbada hilibka iyo alaabta biyaha.

Sanadihii la soo dhaafay, polyphenols shaaha ee hilibka doofaarka, hilibka lo'da, hilibka lo'da iyo hilibka kale iyo noocyo kala duwan oo kalluun ah, surimi, kubbadaha kalluunka iyo shrimp iyo alaabada kale ee biyaha ayaa la soo sheegay midba midka kale, waa wakiilka ugu fiican ee ilaalinta dabiiciga ah. Tiro badan oo cilmi-baaris ah ayaa muujisay in xoogga sare ee shaaha xal ilaalinta polyphenol, ay si fiican u saameynayso xakamaynta microorganisms ee alaabta hilibka iyo alaabta biyaha, laakiin polyphenols shaaha ayaa saameyn xun ku yeelan doona dareenka dareenka hilibka, taasoo keentay midabka hilibka. polyphenols shaaha waxay joojin karaan koritaanka noocyo badan oo bakteeriya ah, laakiin farsamadeedu ma cadda.

5.Codsiga ilaalinta khudradda iyo khudaarta

Xakamaynta wanaagsan ee luminta biyaha cilmu-nafsiga ee ay keento bakteeriyada waxyeelada leh ee waxyeelada miraha; Polyphenols shaaha waxay leeyihiin saameyn antioxidant sare leh, taas oo hoos u dhigi karta dhaawaca oksaydhka ee miraha iyo khudaarta, waxay nidaamisaa dhaqdhaqaaqa polyphenol oxidase, waxayna kicisaa nidaamka difaaca ee miraha iyo khudradda. Isla mar ahaantaana, shaaha polyphenol molecules waxaa ku jira tiro ka mid ah kooxaha phenolic hydroxyl firfircoon, kuwaas oo si toos ah u siin kara hydrogen ee molecules vitamin C ee miraha iyo khudaarta, si ay u ilaalin karto xaalad hoos u dhacdey oo ay u yarayso khasaaraha vitamin C.

Isku-duubnaanta hoose ee polyphenols-ka shaaha ee lagu buufiyo ama lagu dahaadhay dusha sare ee miraha iyo khudaarta cusub waxay joojin kartaa taranka bakteeriyada waxayna kordhisaa nolosha cusub ee miraha iyo khudaarta. Habka haynta cusubi waa mid adag, arrimaha ugu muhiimsanina way ka duwan yihiin noocyada kala duwan ee miraha iyo khudaarta. Intaa waxaa dheer, polyphenols shaaha ayaa sidoo kale dib u dhigi kara xilliga bislaanshaha ka dib ee miraha iyo khudaarta, sababtoo ah waxay saameyn ku yeelanaysaa dhaqdhaqaaqa biochemical ee miraha iyo khudaarta. Si kastaba ha ahaatee, habka ilaalinta ee polyphenols shaaha ee miraha iyo khudaarta kala duwan ma aha isku mid, iyo qiyaasta loo baahan yahay iyo shuruudaha isticmaalka walxaha kala duwan, taas oo sidoo kale u baahan cilmi-baaris dheeraad ah.

Codsiga polyphenols shaaha ee daawada

1, anti-oxidation iyo ka-hortagga shucaaca

Sababtoo ah qaab-dhismeedka kiimikada ee gaarka ah, polyphenols shaaha waxay leeyihiin awood aad u xoog badan, taas oo aad uga badan antioxidants caadiga ah sida VC, VE iyo antioxidants macmal ah BHT, BHA iyo wixii la mid ah. Intaa waxaa dheer, polyphenols shaaha ayaa sidoo kale ka saari kara xagjiriinta xorta ah ee waxyeellada leh, kor u qaadida difaaca jirka, iyo soosaarayaasha catechin waxay sidoo kale yareyn karaan sunta biraha culus ee jirka bini'aadamka iyo saameynta ka hortagga shucaaca, sidaas darteed waxaa sidoo kale loo yaqaan "busters shucaaca".

2.shaqada hemostatic

Polyphenols shaaha waxay leeyihiin waxqabadyo antioxidant iyo bakteeriyada, sidaas darteed waxay joojin karaan cadaadiska oksaydhka iyo taranka bakteeriyada ee goobta boogta, waxay kor u qaadaan samaynta xididdada dhiigga ee vitro iyo kaydinta kolajka, waxay kiciyaan unugyada dhiigga cas iyo neutrophils, waxayna si degdeg ah u joojiyaan dhiigbaxa. Borotiinnada, arrimaha xinjirowga dhiigga, platelets iyo fibrin ee goobta boogta waxay ku daraan polyphenols shaaha si ay u soo saaraan qaybaha xinjirowga waxayna dardargeliyaan bogsashada boogaha.

3.Daawaynta Antitumor

Polyphenols shaaha, gaar ahaan derivatives catechin, waxay leeyihiin saamaynta anti-mutation iyo anti-kansarka, taas oo ka hortagi kara oo joojin kara habka lipid peroxidation, ilaalinta iyo hagaajinta hawlaha enzyme ee jidhka bini'aadamka, iyo muujiyaan saamaynta wanaagsan ee ka hortagga iyo daaweynta adjuvant ee kansarka caloosha, kansarka mindhicirka iyo cudurrada kale.

4, waxay yaraysaa dufanka dhiiga, waxay joojisaa atherosclerosis

Polyphenols shaaha ayaa si weyn u xakameyn kara kororka kolestaroolka ee plasma iyo beerka, waxay saameyn ku yeelan karaan kor u qaadida qashinka dufanka leh ee saxarada, ma aha oo kaliya inay ka hortagto atherosclerosis, laakiin sidoo kale waxay leedahay saameynta miisaan lumis. Waxaa ka mid ah, EGCG iyo catekins kale waxay habeeyaan dheef-shiid kiimikaadka dufanka leh iyagoo xakameynaya nuugista nafaqooyinka ee mareenka caloosha iyo mindhicirka, xakamaynta samaynta unugyada baruurta iyo dufanka, nidaaminta flora mindhicirka, iyo hagaajinta caabbinta insulin.

5.Ka hortagga cudurada wadnaha iyo xididada

Polyphenols shaaha waxay leeyihiin ka hortag wanaagsan iyo saameyn daweyn oo ku saabsan cudurrada wadnaha iyo xididdada, gaar ahaan joojinta atherosclerosis ee ay keento kolestaroolka sarreeya iyo maadada triglyceride. Intaa waxaa dheer, polyphenols shaaha ayaa sidoo kale kaa caawin kara ilaalinta iyo hoos u dhigista cadaadiska dhiigga waxayna nidaamiyaan dheef-shiid kiimikaadka sonkorta si loo yareeyo heerarka sonkorta dhiigga.

6.Anti-oxidation iyo anti-gabowga

Polyphenols shaaha waxay ka saari karaan xagjirnimada xad-dhaafka ah ee jidhka bini'aadamka waxayna hoos u dhigtaa gabowga jidhka bini'aadamka. Dhaqdhaqaaqa antioxidant ee polyphenols shaaha ayaa ka xoog badan VE, wayna ka fiican tahay marka lagu daro VC iyo VE.

7.kahortagga suuska

Waxaa la caddeeyey in polyphenols shaaha ay si adag u joojin karaan bakteeriyada cariogenic waxayna si weyn u yareeyaan xuubka iyo index periodontal.

8.Bakteeriyada iyo fayraska

Polyphenols waxay soo dajin kartaa borotiinka unugga, denaturate oo barootiinka unugyada shaqada joojin kara. Isticmaalka mabda'a bakteeriyada bakteeriyada iyo polyphenols-ka-hortagga fayraska, catechins ayaa loo isticmaalay qaboojiyaha dibadda. EGCG ee TP-yada waxay ku xidhi kartaa xuubka dufanka ee bakteeriyada waxayna saameeyaan dheef-shiid kiimikaadka folate ee bakteeriyada iyadoo la xakameynayo cytoplasmic enzyme dihydrofolate reductase, sidaas darteed lagu gaaro ujeedada bakteeriyada.