Awoodda mannose-ka ee goobta dawooyinka ayaa inta badan ku urursan dhowr jiho oo gaar ah, kuwaas oo qaarkood horeba loogu dabaqay bukaan-socod (sida ka-hortagga caabuqa kaadi mareenka), halka kuwa kalena ay ku jiraan cilmi-baarista aasaasiga ah ama marxaladda tijaabada caafimaad ee hore. Rajada ayaa mudan in fiiro gaar ah loo yeesho, laakiin caddayn dheeraad ah ayaa loo baahan yahay si loo taageero. Sharaxaad ka bixi kartideeda meelaha soo socda:

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1. Goobaha Codsiga ee la aqoonsan yahay/Bislaaday

Ka hortagga caabuqa kaadi mareenka ee soo noqnoqda (rUTI) ?

Mechanism: Maareynta afka ee mannose-ku waxay keentaa in kaadidu si aad ah u soo baxdo, si tartan ah u xannibto xidhitaanka FimH pilin adhesins ee cudurada sida Escherichia coli ilaa unugyada epithelial ee kaadiheysta, ka hortagga bakteeriyada inay gumeysato oo ay kaadidu dhaqdo.

Caddeyn:

Daraasado dhowr ah oo kiliinig ah, sida isbarbardhigga antibiyootiga furantoin, ayaa muujiyay in 1.5-2g oo mannose ah maalintii ay waxtar u leedahay sida antibiyootiga hooseeya ee ka hortagga rUTI ee ay keento Escherichia coli ee haweenka, waxayna leedahay khatar hoose oo iska caabin ah.

Tilmaamaha Ururka Yurub ee Urology (EAU) waxay ku taxan yihiin beddelka ka hortagga rUTI (Heerka caddaynta: B).

Faa'iidooyinka: Badbaadada sare (waxyeellooyinka caloosha iyo mindhicirka fudud), khatar uma laha iska caabbinta antibiyootiga ballaaran.

Xaddidaad: Kaliya ayaa lagu dabaqi karaa ka-hortagga mana beddeli karo antibiyootiga daaweynta caabuqyada degdega ah; Saamaynta ay ku leedahay non-Escherichia coli UTI waa mid xadidan.

2. Meelaha marxaladda cilmi-baarista laakiin leh awood cad

Daawaynta Cudurka Glycation ee lagu Dhashay (CDG)

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Mechanism: Qaar ka mid ah noocyada CDG-ga, sida MPI-CDG (nooca CDG-Ib), waxaa ka maqan fosfomannose isomerase (PMI), taas oo ka hortagaysa beddelka mannose-6-fosfate ilaa fructose-6-fosfate, taasoo keenta in xubno badan ay fashilmaan.

Daaweynta: Maareynta afka ee mannose waxay dhaafi kartaa cilladaha PMI waxayna si toos ah u siin kartaa mannose-6-phosphate, soo celinta isku-darka glycoprotein.

Xaalada hadda:

FDA waxay ogolaatay isticmaalka mannose MPI-CDG, kaas oo ah mid ka mid ah noocyada yar ee la daweyn karo ee CDG.

Horumar la taaban karo oo ku yimid cudurka beerka, xinjirowga dhiigga oo xumaada, iyo calaamadaha caloosha iyo mindhicirka, laakiin daawaynta nolosha oo dhan ayaa loo baahan yahay.

Suuragal ah: U baadh qiimaha daawaynta adjuvant ee noocyada kale ee CDG, sida ALG-CDG.

Nidaaminta difaaca jirka ee antitumor iyo gaarsiinta daawada ????

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Farsamaynta:

Makrofajiyada buro ee lala beegsaday (TAMs) receptors mannose aadka u muujiya (MRC1), iyo dawooyinka mannose modified waxaa loo geyn karaa burooyinka qaab la beegsaday.

Xakamaynta xakamaynta difaaca jirka: Mannose si tartan ah u joojiya soo-dhoweynta mannose ee dusha TAM-yada, iyaga oo xannibaya aqoonsiga antigens-ka mannose glycated ee dusha unugyada burooyinka, taas oo laga yaabo inay dib u dhigto xakamaynta difaaca.

Kobcinta dareenka kemotherabi: Daraasadaha xayawaanka, isku-darka mannose iyo kiimoterabiga (sida doxorubicin) waxay si weyn u joojin karaan koritaanka burada (laga yaabo inay farageliyaan dheef-shiid kiimikaadka gulukooska).

Caqabada: Cilmi baaris dheeraad ah ayaa loo baahan yahay oo ku saabsan waxtarka aadanaha, qiyaasta ugu wanaagsan, iyo hababka gaarsiinta.

Daawooyinka caabuqa ee fungal/antiparasitic adjuvants ??

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Mechanism: Cudurada sida Candida albicans iyo Plasmodium waxay ku tiirsan yihiin daaweeyayaasha mannose ee martida loo yahay si ay u duulaan unugyada. Mannose waxay xannibi kartaa ku dhegganaanshaha.

Cilmi baaris:

In vitro iyo moodooyinka xayawaanka ayaa muujiyay in mannose uu joojin karo ku-xidhka Candida ee unugyada epithelial.

Isticmaalka wadajirka ah ee dawooyinka ka hortagga duumada waxay yarayn kartaa heerka caabuqa dulinnada duumada (tijaabooyin xayawaan ah).

Suuragal ah: Caawin ahaan si kor loogu qaado waxtarka daawooyinka ka hortagga caabuqa ee jira oo loo yareeyo caabbinta daroogada.

3. Jihooyinka sahaminta ee soo baxaya ( suurta gal in la xaqiijiyo)

Cudurka caabuqa bararka (IBD) iyo hagaajinta xannibaadaha mindhicirka ??

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Male:

Mannose waxaa laga yaabaa inay nidaamiso microbiota mindhicirka (kor u qaad bakteeriyada faa'iidada leh) oo waxay joojisaa ku dhegganaanta bakteeriyada pathogenic.

Kobcinta shaqada borotiinnada xannibaadaha xuubabka mindhicirka iyada oo loo marayo beddelidda glycosylation.

Xaaladda hadda jirta: Noocyada xayawaanka (colitis) waxay muujinayaan saameyn difaac ah, laakiin cilmi-baarista bini'aadamka ayaa ka maqan.

Nidaaminta cudurrada difaaca jirka ??

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Aragti: Glycosylation aan caadi ahayn ayaa ku lug leh pathogenesis ee rheumatoid arthritis-ka, lupus, iyo cudurrada kale. Kaabista mannose waxay hagaajin kartaa cilladaha glycosylation.

Horumarka: Kaliya lagu arkay moodooyinka unugyada ama tiro aad u yar oo kiisas ah, iyada oo aan la helin tijaabooyin caafimaad oo adag.

Kahortagga dhibaatooyinka xanuunka macaanka ??

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Macquul: Sonkorta dhiigga oo sareysa waxay keentaa glycation-ka xad-dhaafka ah ee borotiinnada, taasoo keenta dhibaatooyin. Dheef-shiid kiimikaadka mannose kuma xidhna insulinta mana saamayso gulukoosta dhiigga, ama waxay si tartan ah u yareeyn kartaa samaynta AGE-yada.

Caddeymo: Tijaabooyinka xayawaanku waxay muujinayaan in horumarka cudurka macaanka nephropathy uu hoos u dhacay, cilmi-baarista bini'aadamkuna ay bannaan tahay.

4. Caqabadaha iyo caqabadaha

Caqabadaha ugu waaweyn ee goobta

Ka-hortagga UTI waa mid aan waxtar lahayn oo liddi ku ah cudur-sidaha Escherichia koli; Xogta badbaadada muddada dheer oo aan ku filnayn (gaar ahaan saamaynta shaqada kelyaha)

Daawaynta CDG waxay wax ku ool u tahay oo kaliya noocyada hoose ee gaarka ah; Baaritaanka hore iyo daawaynta nolosha oo dhan ayaa loo baahan yahay

Waxtarka daaweynta burooyinka ee jirka bini'aadamka lama garanayo; Qaadashada sare waxay keeni kartaa shuban; Khatarta sunta ah ee isku darka kemotherabi waxay u baahan tahay in la qiimeeyo

Waxtarka aan ku filneyn ee isticmaalka hal mar ee adjuvant anti-infective; Baahida loo qabo in la hagaajiyo daaweynta isku dhafka ah ee daawooyinka jira

Cilmi-baaris daciif ah oo ku saabsan hababka meelaha kale ee soo baxaya; La'aanta tijaabooyin caafimaad oo tayo sare leh; Intooda badan waxay ku sii jiraan marxaladda nooca xayawaanka

5. Jihada horumarka mustaqbalka

Horumarinta nidaamka gaarsiinta saxda ah: Naqshad mannose wax ka beddelka nano-xambaarayaasha si kor loogu qaado bartilmaameedsiga burada/ dhaawaca faafa.

Isku-darka daaweynta: sahaminta saamaynta is-dhexgalka ee mannose ee leh antibiyootiga, xakamaynta isbaarada difaaca, iyo daawooyinka fangaska.

Balaadhinta Cudurada Naadirka ah: Baadhitaanka noocyo badan oo CDG ah iyo cilladaha kaydinta lysosomal kuwaas oo lagu daweyn karo mannose.

Qaabaynta sii-daynta joogtada ah ee sii-daynta dheer: waxay xallisaa dhibaatada dawooyinka soo noqnoqda (sida isticmaalka maalinlaha ah ee ka-hortagga UTI).

Istaraatiijiyada kala soocida dadweynaha: daawaynta saxda ah ee ku salaysan nooca cudur-sidaha (UTI) ama isbeddelka hidda-wadaha (CDG)