Cudurka beerka ee khamriga (ALD), oo ah cudur beerka ku dhaca oo uu keeno cabbitaanka badan ee muddada dheer, waa mid ka mid ah cudurrada beerka ee caadiga ah ee Shiinaha, oo ay ku jiraan beerka dufanka leh, cagaarshowga khamriga, beerka khamriga iyo cirrhosis khamriga. Sanadihii la soo dhaafay, faafitaanka cudurka beerka khamriga ayaa muujiyay isbeddel sii kordhaya ee Shiinaha.

Bishii Luulyo 2, 2024, Liu Zhihua oo ka tirsan Jaamacadda Tsinghua, Wang Hua oo ka tirsan Jaamacadda Caafimaadka ee Anhui, Yin Shi oo ka tirsan Jaamacadda Sayniska iyo Teknolojiyadda Shiinaha iyo cilmi-baarayaal kale ayaa daabacay maqaal cinwaan looga dhigay "Fiber-ka cuntada wuxuu yareeyaa dhaawaca beerka khamriga iyada oo loo marayo" joornaalka Cell Host & Microbe "Bacteroides acidifaciens iyo ammonia demitoxification".

Cunto qani ku ah faybarka cuntada ee milmi kara ayaa la ogaaday inay kordhiso badnaanta B.

Habka, B.accifaciens waxay nidaamisaa dheef-shiid kiimikaadka bile acid iyada oo loo marayo enzyme bile saline hydrolysis (BSH). Kordhinta bile acid ee aan xidhnayn waxay kicisaa dariiqa FXR-FGF15 ee xiidmaha, waxay ilaalisaa shaqada xannibaadda mindhicirka, waxay kor u qaadaa muujinta aminotransferase ornithine (OAT) ee hepatocytes, oo sidaas awgeed waxay kor u qaaddaa dheef-shiid kiimikaadka ururinta ornithine ee beerka si ay u glutamate. Sii alaabta ceeriin ee sun-saaridda beerka oo yaree dhaawaca unugyada beerka.

Daraasaddan, cilmi-baarayaashu waxay markii ugu horreysay keeneen cudurka beerka khamriga ee qaabka jiirka waxayna falanqeeyeen saameynta fiber-ka-cuntadu ku leedahay cudurka beerka khamriga ee jiirarka iyadoo la kordhinayo fiber-ka milmay iyo kuwa aan milmin labadaba.

Natiijooyinku waxay ogaadeen in dheellitirka fiber-ka-cuntadu ay si weyn u wanaajisay cudurrada beerka khamriga ee jiirarka, oo ay ku jiraan yaraynta steatosis beerka iyo yaraynta boqolkiiba iyo tirada guud ee neutrophils beerka, halka fiber-ka cuntada ee aan milmi lahayn saameyn weyn.

Sababtoo ah fiber-ka cuntada ayaa si weyn u saameyn kara microbiota mindhicirka, cilmi-baarayaashu waxay sii falanqeeyeen haddii horumarinta cudurka beerka khamriga ay sabab u tahay microbiota mindhicirka iyada oo loo marayo farsamooyinka tallaalka microbiota.

Ka dib markii la tallaalo, waxaa la ogaaday in ku-tallaalidda microflora ee jiirarka la quudin jiray fiber-ka-cuntadu ay hoos u dhigtay serum alanine aminotransferase (ALT) iyo aspartate aminotransferase (AST), iyada oo la dhimayo steatosis beerka iyo heerarka caabuqa, taasoo soo jeedinaysa in fiber-ka cuntada ee milmay ay saameyn ku yeelan karto horumarinta ALD adoo dib u habeynaya halabuurka microflora mindhicirka.

Daraasadu waxay muujisay in fiber-ka-cuntadu ay wanaajisay necrosis unugyada beerka, steatosis beerka iyo bararka qaabka jiirka ee cudurka beerka khamriga, iyo sidoo kale hoos u dhigista heerka ammonia dhiigga iyo walbahaarka oksida, muujinta doorka muhiimka ah ee fiber-ka cuntada ee ka hortagga iyo daaweynta cudurka beerka khamriga.

Waxaa muhiim ah in la ogaado in dadka waaweyn guud ahaan lagula talinayaa in ay isticmaalaan 25-30 garaam ama in ka badan oo fiber cunto ah maalintii, laakiin dadka intooda badan ma kulmaan talooyinka cuntada. Miraha oo dhan, miraha iyo khudaarta ayaa ah ilo qani ah oo laga helo fiber-ka cuntada waxayna bixin karaan nafaqeeyayaalka yar yar ee kale ee muhiimka ah.

Marka la soo koobo, natiijadu waxay soo jeedinaysaa in cunto qani ku ah fiber-ka-cuntadu ay wanaajin karto dhaawaca beerka ee khamriga ee moodooyinka jiirka iyada oo la ilaalinayo daacadnimada xannibaadda mindhicirka. Daraasadani waxay leedahay qiime caafimaad oo gaar ah iyo muhiimad bulsho.

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