1.1 Ho tloha ho lokisoa ha membrane ea sele ho ea taolong ea Cerebrovascular

Kaha Citicoline e qalile ho etsoa ke Takeda Pharmaceutical ea Japane ka 1956, nalane ea ts'ebeliso ea eona e ka nkuoa e le nalane ea ntlafatso ea kelello:

• Lilemong tsa bo-1980:E sebelisoa feela e le sesebelisoa sa ho lokisa lera la sele kamora ho otloa ke stroke

• 2010s:Ho ile ha fumanoa hore e ka eketsa cerebral blood perfusion (PET-CT e bont?itse keketseho ea 23% ea phallo ea mali ea nakoana)

• Ka 2024,NIH ea United States e e thathamisitse e le ntho ea bohlokoa ea taolo bakeng sa "neurovascular coupling"

1.2 Keketseho e matla ea 'maraka oa lefats'e

Ho latela data ea Evaluate Pharma:

Thekiso ea lefats'e e fihlile ho lidolara tse limilione tse likete tse 4.7 ka 2024 (CAGR 12.3%).

T?ebeliso ea lithethefatsi lipetleleng tsa mehlala ea Chaena e eketsehile ka 400% ka lilemo tse tharo

Lipont?o li atoloselitsoe ho:

Vascular dementia (Palo ea MMSE e ntlafalitsoe ka lintlha tse 2.1)

Kotsi e bohloko ea boko (sekala sa tsoelo-pele sa GOS se eketsehile ka limaraka tsa 1.5)

Khaolo ea Bobeli: Lebokose le Let?o ho Petsoha ha Mokhoa oa Ts'ebetso

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2.1 Mekhoa e meraro ea liketso

Boemo ba bopaki ba phello ea sepheo: Phosphatidylcholine synthesis lokisa neuronal membrane integrity Sehlopha sa I: Li-precursors tsa Acetylcholine li ntlafatsa phetisetso ea li-neurotransmitter Sehlopha sa IIA: Taolo ea Nitric oxide synthase e ntlafatsa phallo ea microvascular (keketseho ea bophara ka 18%) Sehlopha sa IIB

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2.2 Clinical golden window nako

Phuputso ea 2024 e entsoeng ke Sepetlele sa Pele se Kopanetsoeng sa Univesithi ea Sun Yat-sen e bont?a:

Ente ea methapo ea 1000mg nakong ea lihora tse 6 ka mor'a lefu la boko le ka boloka sebaka sa ischemic penumbra ho fihlela ho 7.2cm.3

Leha ho le joalo, ho ne ho se na phapang e kholo ea lipalo-palo ha tsamaiso e feta lihora tse 72 (p = 0.34).

Khaolo ea Boraro: The Vortex of Controversy

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3.1 Lipelaelo mabapi le Bot?epehi

Litaelo tsa UK NICE: Ho nkoa hore bopaki bo teng ha boa lekana ho t?ehetsa inshorense ea bophelo bo botle (karolelano ea lit?enyehelo tsa ￡ 45,000 / QALY)

Lancet Neurology **2025 Meta-analysis: Ha ho phapang e kholo ho tloha ho placebo sehlopheng sa bokooa bo fokolang ba kelello (p=0.21)

3.2 Moferefere Khothatsong ea Khoebo

Tsebiso ea 2024 ea National Medical Products Administration:

Likhoebo tse leshome le metso e 'meli li feteletsa mat?oao (ho khothaletsa "phekolo ea adjuvant" e le "ho khutlisa dementia").

Liteko sethaleng se itseng sa e-commerce li bonts'a hore litaba tsa 'nete tsa 32% ea litokisetso tsa molomo li ka tlase ho 70% ea chelete e ngolisitsoeng.

Khaolo ea bone: Meeli ea Tsoelo-pele ea Theknoloji

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4.1 Mokhoa o Mocha oa phano ea Lithethefatsi

T?itiso ea mali-bokong e kenang ka peptide e fetotsoeng liposomes (Patent ea Sehlopha sa Univesithi ea Peking, CN202410123456.7)

Li-microneedle tse arabelang ka nako e telele (Liteko tsa liphoofolo Univesithing ea Seoul National Korea Boroa li bont?a keketseho e imenneng hararo ea bioavailability)

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4.2 Ho qala ha Meriana ka Motho ka Mong

Patlisiso e kopaneng ea Bgi e fumane hore:

Phello ea meriana ea CDP-cholinesterase gene polymorphic population (e ikarabellang bakeng sa 31% ea baahi ba Asia) e eketsehile ka 47%.

Khaolo ea Bohlano Boitsebiso ba 'Nete ba Lefat?e la Bakuli

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5.1 Linyeoe tsa Mojalefa

Rekoto e tsoang sepetleleng sa thuto e phahameng ea Hangzhou: Kamora kalafo e kopaneng, matla a phallo ea mali a boko a mokuli ea lilemo li 62 ea nang le cerebral infarction a folile ho tloha ho 32% ho isa ho 89%.

5.2 Boikutlo ba mokha o sa sebetseng

"Ho e nka nako ea halofo ea selemo e sa khaotse, lit?enyehelo tsa khoeli le khoeli tsa li-yuan tse 300 li ile tsa baka bohloko ba mpa" - tlaleho ea lipuisano ea Mme Li, mokuli ea tsoang Beijing.