Citicolineke nucleotide e le 'ngoe e entsoeng ka nucleic acid, cytosine, pyrophosphate le choline, e sebelisoang haholo-holo kalafo ea meriana ea mafu a sa t?oaneng a neurodegenerative, a kang lefu la Alzheimer, multiple sclerosis, amyotrophic lateral sclerosis joalo-joalo. Boithuto bo boetse bo bonts'itse hore citicoline e ka eketsa ts'ebetso ea boko ea dopamine le glutamate, ka hona, ea ntlafatsa ts'ebetso ea kelello. Ciphocholine e ka boela ea fokotsa ho lokolloa ha mafura a mafura a mahala le ho tsosolosa mosebetsi oa mitochondrial ATPase le membrane ea sele Na +/K + ATPase, kahoo e fokotsa kotsi ea boko. Leha ho le joalo, mekhoa ea pathophysiological ea mafu a neurodegenerative e rarahane ebile e kenyelletsa khaello ea cholinergic, glutamate excitotoxicity, neuroinflammation, ho se sebetse hantle ha 'mele oa ho it?ireletsa mafung, ho fokotseha ha metabolism ea tsoekere, le ho putlama ha t?itiso ea mali le boko.

Citicolinee ka tsitsisa lera la sele ka ho susumetsa S-adenosine-L-methionine, ho eketsa ho rarahana ha dendrite le spinous process density ea motor neuron structure, ho ntlafatsa polasetiki ea methapo libakeng tse sa senyeheng, le ho khothaletsa ho hlaphoheloa ha t?ebetso.

Citicoline e ka fokotsa boemo ba lecithin phosphate e qhibilihang ka metsing ka ho phahamisa choline phosphate cytidylytransferase (CCT) le ho thibela mosebetsi oa secretory phospholipase A2 (PLA2) kapa ho thibela ts'ebetso ea PLA2 ka ho thibela TNF-a / IL-1b ho fokotsa tahlehelo ea phosphoslipid e ntseng e eketseha ea phospholipase le membrane ea methapo ea kutlo.

Citicoline e ka boela ea eketsa polelo ea lintho tse khahlanong le apoptotic tse kang Bcl-2 le ho thibela ho lokolloa ha glutamate ho fokotsa cytotoxicity.

Ciphocholine e khothalletsa ho lokisoa ka potlako ha libaka tse senyehileng tsa lisele le li-membrane tsa mitochondrial, e boloka ho tiea ha lisele le ts'ebetso ea likokoana-hloko, 'me e fokotsa ho lokolloa ha mafura a mahala, kahoo e fokotsa metabolite e chefo ea oksijene le tlhahiso ea mahala ea radical.

Citicoline e ka eketsa maemo a vasopressin le plasma adrenotropin, 'me ea susumetsa ho lokolloa ha hormone ea ho hōla, thyrotropin le luteinizing hormone.

Ho na le mekhoa e mengata ea ho itokisa ea citicoline sodium, haholo-holo mekhoa e meraro.

E 'ngoe ke ho belisoa ha likokoana-hloko. Mokhoa ona o na le mathata a mang a kang ho tsepamisa mohopolo oa lihlahisoa tse tlaase le chai e sa tsitsang.

E 'ngoe ea tsona ke organic chemical synthesis. Ho na le mathata a mang ka mokhoa ona, joalo ka hore sehlahisoa se thata ho arohana le motsoako oa shrinkage, ha se loketse t?ebeliso ea meriana, tekanyo e tlaase ea phetoho ea karabelo, lihlahisoa tse ngata, theko e phahameng le t?ilafalo e tebileng ea tikoloho.

Ho boetse ho na le mokhoa oa ho kopanya enzymatic, joalo ka t?ebeliso ea seretse sa tomoso ea biri le likokoana-hloko tse ling bakeng sa biosynthesis. Lisele tsa seretse sa tomoso tsa motho ea ritelang mahala li ne li sebelisetsoa ho kopanya enzymatic. Mokhoa ona o ne o le bonolo, sekhahla sa ho sokoloha se ne se le holimo 'me lit?enyehelo li ne li le tlaase. Ts'ebetso ea tlhahiso ea sodium ea citicoline e entsoeng ka synthesis ea enzymatic e ka aroloa likarolo tse peli: ts'ebetso ea enzymatic synthesis le ts'ebetso ea ho nt?a le ho hloekisa.

E nkiloe ka molomo, e kenngoa ka potlako, e kenngoa ka hydrolyzed ka maleng le sebeteng ho choline le cytosine, tse kenang mali, li t?ela mokoallo oa mali-boko, 'me li kopane hape ka citicoline tsamaisong ea methapo e bohareng, moo 80% ea phospholipid synthesis e amehang ke mahloriso a citicoline' meleng.

Ho phaella moo, citicoline e fetoloa ho acetylcholine tsamaisong ea methapo e bohareng le oxidized ho betaine liphio le sebete. Sollubility ea metsi ea citicoline e ntle, bioavailability e ka holimo ho 90%, 'me ke ka tlase ho 1% feela e nt?oang setulong ka mor'a ho tsamaisoa ka molomo. Ho na le litlhoro tse 2 tsa ho monya ho plasma, hora e le 1 le lihora tse 24 kamora ho kenngoa.

Mehlala ea likhoto, maemo a radiolabelled citicoline a ile a eketseha butle-butle bokong lihora tse 10 ka mor'a hore a jeoe 'me a ajoa ka ho pharaletseng ka taba e t?oeu le e putsoa ea boko. Metsoako e phahameng e sala lihora tse 48, 'me ho felisoa ha eona ho lieha haholo, ka tekanyo e nyenyane feela e nt?oang letsatsi le leng le le leng ka moroto, mantle le ho hema. Ho kenngoa ka ntle ho citicoline ho ka khothalletsa ho lokisoa ka potlako ha lisele tse senyehileng le mitochondria, ho boloka bot?epehi ba lisele le ts'ebetso ea likokoana-hloko, le ho thibela apoptosis le lefu.