Ena ke tlhahlobo ea morao-rao, e hatisitsoeng koranteng e tummeng ea Nutrients ka February 2024, ke Ligia J. Dominguez le ba bang ba Univesithi ea Palermo le Univesithi ea Enna Italy. Ba ile ba hlahloba ka mokhoa o hlophisitsoeng kamano pakeng tsa magnesium le mat?oao a botsofali 'meleng oa motho,' me ba fumana hore diminerale ena e tloaelehileng e hlile e ka fokotsa lebelo la botsofali, e leng ntho e makatsang haholo!

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Litlhahiso tsa bohlokoa:

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1. Magnesium ke karolo ea bone ea liminerale tse ngata ka ho fetisisa 'meleng oa motho' me e amana haufi-ufi le mosebetsi oa li-enzyme tse fetang 600, tse amang mekhoa e sa t?oaneng ea 'mele.

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2.Khaello ea Magnesium e tloaelehile haholo ho batho ba hōlileng, e amanang le lintlha tse ngata tse kang liphatsa tsa lefutso, tikoloho le mokhoa oa bophelo. Maemo a sa lekaneng a magnesium 'meleng a ka potlakisa botsofali.

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3. Liphuputso li fumane hore magnesium e ka ama likarolo tsa bohlokoa tsa 12 tsa botsofali, ho kenyeletsa ho se tsitse ha genomic, khutsufatso ea telomere, le liphetoho tsa epigenetic. Magnesium supplementation e lebeletsoe ho liehisa botsofali le ho ntlafatsa litebello tsa bophelo bo botle.

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Kakaretso e felletseng ea sengoloa sa mantlha ke ena:

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Khaello ea Magnesium e potlakisa lit?obotsi tse 12 tsa botsofali

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Ho se tsitse ha Genomic: Magnesium e tsitsisa sebopeho sa DNA habeli helix mme e ameha mekhoeng e fapaneng ea ho lokisa DNA. Khaello ea Magnesium e ka lebisa ho bokelleng ha t?enyo ea DNA, ho eketseha ha liphatsa tsa lefutso, le botsofali bo potlakileng.

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Ho khutsufatsa ha Telomere: Li-telomere ke tatellano e pheta-phetoang qetellong ea li-chromosome tse sireletsang genome ho senyeha. Magnesium e tsitsisa qetello.

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Liphetoho tsa Epigenetic: Liphetoho tsa Epigenetic liphatseng tsa lefutso li etsahala ntle le ho fetola tatellano ea DNA. Magnesium e laola mekhoa ea epigenetic e kang DNA methylation le histone modification.

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Protein homeostasis imbalance: protheine synthesis le ho senyeha ka har'a sele ho fihla ho leka-lekana ho matla, ho bitsoang protheine homeostasis. Magnesium e kenya letsoho ho laola t?ebetso ea proteasome le lysosome, 'me khaello ea magnesium e lebisa ho bokelleng ha liprotheine tse sa phuthoang hantle.

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T?itiso ea maikutlo a phepo e nepahetseng: Insulin / IGF-1 le litsela tse ling tsa lipont?o li lemoha boemo ba phepo ea cellular le ho laola metabolism. Magnesium ke motsoako oa li-insulin receptors le "downstream kinases", 'me khaello ea magnesium e baka ho hanyetsa insulin.

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Ho se sebetse ha Mitochondrial: Mitochondria ke lifeme tsa matla a cellular, 'me DNA ea tsona le liketane tsa ho hema li kotsing ea ho senyeha. Magnesium ke cation ea bobeli e ngata ka ho fetisisa mitochondria, e amehang ho ATP synthesis le antioxidant, 'me khaello ea magnesium e mpefatsa t?enyo ea mitochondrial.

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Boleng ba cellular: lisele tsa senescent li emisa ho arohana, li hlahisa lintho tse ruruhisang, 'me li senya tikoloho ea lisele. Magnesium e ka thibela lisele tse thibelang liprotheine p53 le p21 le ho liehisa senescence ea sele.

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Ho fokotseha ha lisele tsa stem: Lisele tsa stem li ikarabella bakeng sa ho nchafatsa le ho lokisoa ha lisele, 'me palo ea tsona le ts'ebetso ea tsona li fokotseha ka lilemo. Magnesium e ama karohano ea lisele tsa stem tsa hematopoietic, 'me khaello ea magnesium e ka potlakisa ho fokotseha ha lisele tsa stem.

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Liphetoho puisanong ea li-intercellular: li-cytokine, li-hormone, joalo-joalo, li-mediate intercellular signal exchange. Botsofali bo eketsa secretion ea mabaka a ho ruruha. Magnesium e thibela ho ruruha le ho ntlafatsa puisano ea lisele.

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Autophagy e senyehileng: Autophagy ke tsela ea bohlokoa ea hore lisele li theole liprotheine tse senyehileng le li-organelles. Magnesium e boloka t?ebetso ea autophagy ka ho laola t?ebetso ea liphatsa tsa lefutso tse amanang le autophagy le kinase.

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Bothata ba limela tsa mala: limela tsa mala li ameha metabolism ea limatlafatsi le taolo ea 'mele ea ho it?ireletsa mafung,' me ho se leka-lekane ha likokoana-hloko ho amana le botsofali. Magnesium e laola limela tsa mala le ho ntlafatsa bophelo bo botle ba baeti.

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Ho ruruha ho sa foleng: Botsofali bo tsamaisana le ho ruruha ho sa foleng ha boemo bo tlaase 'meleng, ke hore, "ho tsofala ho ruruha". Khaello ea Magnesium e baka ts'ebetso e feteletseng ea litsela tsa ho ruruha tse kang NF-κB le ho mpefatsa karabelo ea ho ruruha.

Ho ea ka palo e kholo ea lithuto tsa epidemiological le liteko tse laoloang ka nako e sa lekanyetsoang, ho eketseha ha lijo tsa magnesium le ho tlatsetsa litokisetso tsa magnesium ho ka fokotsa ho ruruha ho sa foleng ho amanang le lilemo, ho hanyetsa insulin, lefu la pelo, joalo-joalo Le hoja ho se na bopaki bo tobileng ba ho paka hore magnesium e ka lelefatsa bophelo, bopaki bo sa tobang bo bont?a hore tlatsetso ea magnesium e tlatsetsa botsofaling bo botle.

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Le hoja magnesium e batla e sireletsehile, batho ba nang le bothata ba ho fokola ha renal ba lokela ho ba hlokolosi, 'me tekanyo e kholo ea meriana e nooang e ka baka let?ollo. Batho ba baholo ba baholo ba lokela ho etelletsa pele ho fumana magnesium e lekaneng ho tsoa lijong tsa bona, joalo ka meroho e makhasi a matala, lijo-thollo, linate, joalo-joalo Haeba ho hlokahala, latela keletso ea ngaka ho tlatsetsa magnesium, 'me kamehla ho shebella mahloriso a mali a magnesium.

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Bopaki bo felletseng ba liteko le lintlha tsa bongaka:

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Bopaki ba liteko tsa magnesium le genomic botsitso DNA ke liphatsa tsa lefutso tsa bophelo, 'me botsitso ba eona ke motheo oa ts'ebetso e tloaelehileng ea lisele. Boithuto bona bo fumane hore ho na le li-ion tsa magnesium lipakeng tsa hoo e ka bang 50% ea lipara tsa motheo ka har'a sebopeho sa DNA double helix, e bapalang karolo ho tsitsisa sebopeho. Linthong tse phelang tsa mohlala tse kang Escherichia coli le tomoso, tikoloho e tlaase ea magnesium e baka keketseho e kholo ea litekanyetso tsa liphoso tsa ho ikatisa ha DNA. Liteko tsa setso sa fibroblast ea motho li boetse li netefalitse hore magnesium e tlase e ka baka khutsufatso e potlakileng ea telomere le ho laola taolo ea DNA ea liphatsa tsa lefutso. Liteko tsa liphoofolo li bonts'itse hore sistimi ea ts'ireletso ea antioxidant e senyehile liseleng tsa sebete tsa likhoto tse haelloang ke magnesium, mme boemo ba 8-hydroxy-deoxyguanosine, e leng let?oao la t?enyo ea oxidative ea DNA, bo ile ba eketseha. Phuputso ea litoeba e fumane hore ho noa metsi a nang le magnesium e ngata ho lelefatsa bolelele ba telomere le ho fokotsa t?enyo ea DNA. Liphetho tsena li fana ka maikutlo a hore magnesium e bohlokoa bakeng sa ho boloka botsitso ba genomic.

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Lithutong tsa baahi, maemo a magnesium a serum kapa a erythrocyte a 'nile a amahanngoa hampe le lipont?o tse sa t?oaneng tsa ho se tsitse ha genomic, tse kang micronucleus frequency, litekanyetso tsa DNA lihlahisoa tse senyang 8-hydroxy-deoxyguanosine, le bolelele ba telomere. Phuputso ea likarolo tse ka bang 200 ea batho ba baholo ba phetseng hantle e fumane hore ba nang le lisele tse khubelu tsa mali tse tlaase ka ho fetisisa tsa magnesium ba ne ba e-na le peripheral blood lymphocyte telomere lengths, ka karolelano, 11.5% e khut?oanyane ho feta ba nang le maemo a phahameng ka ho fetisisa a magnesium. Phuputso e 'ngoe ea sehlopha sa banna ba 1800 ba lilemo tse bohareng le ba hōlileng ba lilemo tse 45-74 e ileng ea lateloa ka lilemo tse 5 e fumane hore ho ja lijo tsa magnesium ho amana haholo le tekanyo ea t?enyo ea DNA maling a mali a lymphocyte qalong, le hore keketseho e' ngoe le e 'ngoe ea ho kenngoa ha magnesium ea 100mg / ka letsatsi e fokolitse tekanyo ea 5% ea t?enyo ea DNA ka mor'a lilemo tse 5. Sena se fana ka maikutlo a hore tlatsetso ea magnesium ho batho le eona e ka thusa ho boloka botsitso ba genomic.

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Ea bobeli, kamano pakeng tsa mosebetsi oa magnesium le telomerase le botsofali ba lisele Telomeres ke mehaho e khethehileng qetellong ea li-chromosome, tse entsoeng ka ho pheta-pheta TTAGGG le liprotheine tse tlamang telomere, tse sireletsang li-chromosome ho senyeha nakong ea karohano ea lisele. Empa ka liseleng tsa motho, bolelele ba telomere bo khutsufatsoa ka lipara tse 50 ho isa ho tse 100 karohano ka 'ngoe, 'me ha khutsufatso e fihla boleng ba bohlokoa, sele e kena boemong ba senescence. Telomerase ke ribonucleoprotease e lelefatsang tatellano ea telomere, empa hangata e sa bont?oe hampe kapa e sa hlahisoang ka har'a lisele tsa batho ba baholo.

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Ho mouse embryonic fibroblasts (MEF), mahareng a magnesium a tlase a fokolitse ts'ebetso ea telomerase ka ho feta 50% mme a bonts'a likarolo tsa senescence tsa cellular, joalo ka ts'ebetso e eketsehileng ea β-galactosidase le polelo e laoloang ka holimo ea cell cycle inhibitors p16 le p21. Li-phenotypes tsena tsa botsofali li ka khutlisoa kamora kalafo ka li-activator tsa magnesium kapa telomerase. Liphetho tse t?oanang li ile tsa bonoa liseleng tsa motho tsa endothelial le fibroblasts. Liphuputso tsa mekhoa ea limolek'hule li fumane hore magnesium e ka laola bolelele ba telomere ka ho ama polelo le sebaka sa libaka tsa liprotheine tse ling tsa bohlokoa tse rarahaneng tsa telomere, tse kang TRF1 le TRF2. Ho feta moo, magnesium e ka boela ea kenya t?ebetsong litsela tsa lipont?o tse kang AKT le ERK, le ho thibela li-cell cycle inhibitors tse kang p53 le Rb, kahoo li liehisa botsofali ba lisele.

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Lithuto tsa bongaka li boetse li t?ehetsa khokahano lipakeng tsa magnesium le senescence ea cellular. Ho batho ba fetang 100 ba phetseng hantle ba phetseng hantle, maemo a serum magnesium a ne a amana hantle le keketseho ea T lymphocyte mme a amana hampe le maemo a plasma p16. Phuputso e 'ngoe e ne e kenyelletsa batho ba hōlileng ba 250 sechabeng,' me e fumane hore litekanyetso tsa motheo tsa serum magnesium li ne li amana haufi-ufi le liphetoho tsa mat?oao a botsofali ba 'mele tse kang moeli oa ho utloa, matla a ho t?oara, le lebelo la ho tsamaea, ho fana ka maikutlo a hore boemo ba magnesium bo ka ama ts'ebetso ea botsofali ka kakaretso' meleng. Boithuto ba sehlopha sa batho ba fetang 2,000 ba lilemo tse fetang 70 bo bapisa maemo a fapaneng a serum magnesium le kotsi ea lilemo tse 10 ea lefu mme ba fumana hore sehlopha se nang le maemo a tlase a magnesium se na le kotsi ea lefu ka makhetlo a 2.2 ho feta sehlopha se nang le maemo a phahameng ka ho fetisisa. Leha lithuto tsena tsa tlhokomeliso li ke ke tsa paka ka kotloloho sesosa le phello, li ts'ehetsa kamano e matla lipakeng tsa magnesium le botsofali ho latela pono ea baahi.

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Karolo ea magnesium tseleng ea pont?o ea insulin Insulin ke hormone ea mantlha ea taolo ea tsoekere ea mali ea motho. Kamora hore insulin e tlamelle receptor ea eona, e etsa hore motho a iketsetse phosphorylation ea receptor, ebe e kenya t?ebetsong letoto la liprotheine tse tlase tse kang PI3K le AKT, mme qetellong e laola polelo ea liphatsa tsa lefutso tse amanang le metabolism ea tsoekere. Liteko tse ngata li bont?itse hore magnesium e bapala karolo ea bohlokoa hoo e batlang e le mohato o mong le o mong oa pont?o ea insulin. 1. Liseleng tsa beta tsa islet, magnesium e theha MgATP e rarahaneng le ATP ho kenya letsoho ts'ebetsong eohle ea insulin synthesis, processing le secretion. Meleng ea lisele tsa beta tsa mouse le rat, mahareng a magnesium e tlase e fokolitse secretion ea insulin e susumetsang tsoekere ka ho feta 70%. 2. Liseleng tse lebisitsoeng tsa insulin, mosebetsi oa tyrosine kinase oa li-insulin receptors o it?etlehile ka li-ion tsa magnesium, 'me khaello ea magnesium e lebisa ho insulin receptor phosphorylation le t?itiso ea phetisetso ea pont?o e tlaase, e leng se bakang insulin ho hanyetsa. Ho 3T3-L1 adipocytes le L6 skeletal muscle cell, low-magnesium medium e fokolitse ho kenngoa ha tsoekere e susumelitsoeng ke insulin ka 40% ho ea ho 60%. 3. Magnesium e boetse e kenya letsoho taolong ea kutloisiso ea insulin ka ho thibela protheine phosphatase, ho laola polelo ea li-interins, e amang mosebetsi oa li-transporter oa GLUT4 le mekhoa e meng. Liteko tse ling tsa liphoofolo li bont?itse hore tlatsetso e itekanetseng ea lijo tsa magnesium e ntlafatsa ho hanyetsa insulin ho likhoto tse nonneng le tsa mofuta oa 2 oa lefu la tsoekere.

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Lithuto tsa Epidemiological li boetse li t?ehetsa kamano e haufi lipakeng tsa magnesium le glucose metabolism. Boithuto ba Bophelo bo Botle ba Baoki ba US, bo kenyelletseng basali ba ka bang 70,000 ba kaholimo ho lilemo tse 45 bo latetsoeng ka lilemo tse fetang 20, bo fumane hore ba maemong a phahameng ka ho fetesisa a ho noa magnesium ba na le kotsi e tlase ea 27% ea ho ba le lefu la tsoekere la mofuta oa 2 ho feta ba maemong a tlase haholo. Tlhahlobo ea meta ea lithuto tse 25 tsa sehlopha se amang barupeluoa ba ka bang milione e le 'ngoe e bonts'itse hore keketseho e' ngoe le e 'ngoe ea 100mg / letsatsi ea ho ja lijo tsa magnesium e amahanngoa le phokotso ea 8% ho isa ho 13% ea kotsi ea lefu la tsoekere la mofuta oa 2. Ho batho ba nang le lefu la tsoekere le teng, maemo a fokotsehileng a serum magnesium a boetse a amana haufi-ufi le tsoelo-pele ea mafu le mathata. Phuputso e entsoeng ho bakuli ba fetang 300 ba nang le lefu la tsoekere la mofuta oa 2 e fumane hore maemo a serum magnesium a ne a le tlaase haholo ho ba nang le lefu la pelo ho feta ba nang le lefu la tsoekere feela. Qetellong, palo e kholo ea liphuputso e bont?itse hore tlatsetso ea magnesium e ka liehisa botsofali ka ho ntlafatsa ho hanyetsa insulin.

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4. Khaello ea Magnesium le ho se sebetse ha mitochondrial Mitochondria ke libaka tse ka sehloohong tsa metabolism ea matla a cellular le tlhahiso ea mefuta e sebetsang ea oksijene (ROS). Nakong ea botsofali, katleho ea ketane ea lipalangoang tsa elektronike ea mitochondrial e fokotseha 'me tlhahiso ea ROS e eketseha, e baka phetoho ea mtDNA, membrane lipid peroxidation le t?enyo e' ngoe, ho etsa potoloho e mpe le ho potlakisa botsofali ba lisele. Liphuputso li fumane hore karolo ea boraro ea magnesium 'meleng e bolokiloe mitochondria, e leng ea bohlokoa bakeng sa ho boloka sebopeho le ts'ebetso ea mitochondrial. Ho mitochondria ea sebete sa mouse, likaroloana tse robong ho tse 13 tsa adenosine triphosphatase li hloka magnesium joalo ka cofactor. Ho mitochondria ea mouse, magnesium e tlase e ka fokotsa haholo mesebetsi ea li-enzyme tsa bohlokoa potolohong ea asiti ea tricarboxylic, joalo ka isocitrate dehydrogenase le α-ketoglutarate dehydrogenase. Ho mitochondria ea sebete sa rat, khaello ea magnesium e ka fokotsa sekhahla sa motsoako oa ATP ka ho feta 60%, ea fokotsa sekhahla sa taolo ea phefumoloho, 'me ea eketsa tlhahiso ea ROS, e bakang t?enyo e eketsehileng ea mtDNA le sekhahla sa phetoho. Magnesium supplementation e ka fetola ho se sebetse ha mitochondrial. Liseleng tsa mesifa ea masapo le li-cardiomyocyte, magnesium e tlase e ka theola bokhoni ba lera la mitochondrial, ea etsa hore ho buloe ha mitochondrial permeability transition pore (mPTP), ea etsa hore cytochrome C e lokolloe, 'me e qetelle e lebisa ho apoptosis. Liseleng tsa endothelial tsa mothapo oa motho, magnesium e tlase e kenya palo e kholo ea ROS ea mitochondrial ka ho kenya protheine kinase C, e lebisang ho se sebetseng ha endothelial. Phuputso e entsoeng ho bakuli ba fetang 100 ba nang le metabolic syndrome e fumane hore maemo a serum magnesium a ne a amana hantle le ts'ebetso ea phefumoloho ea mitochondrial mme a amana hampe le maemo a ROS a mitochondrial. Ka bokhut?oanyane, bopaki bo ka holimo bo fana ka maikutlo a hore magnesium ke ntho ea bohlokoa ho boloka homeostasis ea mitochondrial, 'me ho se sebetse ha mitochondrial ke e' ngoe ea mekhoa ea mantlha ea botsofali.

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Ea bohlano, karolo ea taolo ea magnesium mabapi le ho ruruha ho sa foleng le botsofali ba ho it?ireletsa mafung Ho ruruha ho sa foleng ha boemo bo tlaase ke t?obotsi e 'ngoe ea bohlokoa ea botsofali. Liphuputso li fumane hore maemo a ho ruruha a kang IL-6 le TNF-α ho batho ba tsofetseng a eketseha haholo, ha litekanyetso tsa li-cytokine tse khahlanong le ho ruruha tse kang IL-10 li fokotsehile, 'me linaha tsena tse sa foleng tse bakoang ke botsofali li tsejoa e le "ho ruruha". Botsofali ba ho ruruha bo ka baka t?enyo ea lisele le ho se leka-lekane ha 'mele oa ho it?ireletsa mafung, e leng motheo oa mafu a mangata a sa foleng. Liphuputso tsa liteko li bont?itse hore khaello ea magnesium e ka baka karabelo ea ho ruruha le ho se sebetse hantle ha 'mele. Ka setso sa macrophage ea mouse, magnesium e tlaase e ka phahamisa-ho laola mosebetsi oa NF-κB le ho khothalletsa ho lokolloa ha lintho tse sa t?oaneng tsa ho ruruha. Liseleng tsa bronchial epithelial tsa likhoto, secretion ea IL-6 le IL-8 e ka eketsoa ka makhetlo a 2 ho isa ho a 3 ka ts'usumetso ea LPS tlasa tikoloho e tlase ea magnesium. Liseleng tsa batho tsa endothelial, magnesium e tlase e ka kenya t?ebetsong tsela ea pontso ea p38 MAPK, ea etsa hore polelo ea limolek'hule tsa ho khomarela li-intercellular li laoloe, 'me li mpefatsa karabelo ea ho ruruha. Likhotong tse haelloang ke magnesium, litekanyetso tsa TNF-α, CRP le interleukin ho potoloha le lisele li ile tsa eketseha haholo, 'mele oa' mele oa ho it?ireletsa mafung e ne e le atrophy, palo le mosebetsi oa T le B lymphocyte li fokotsehile, 'me ho it?ireletsa mafung ho ile ha mpefala. Magnesium supplementation e ka imolla ka katleho mathata ana a ho ruruha le a ho it?ireletsa mafung. Liphuputso tsa bongaka li boetse li fumane hore magnesium e tlaase e amana haufi-ufi le ho ruruha ho sa foleng. Boithuto bo fapaneng ba batho ba baholo ba fetang 5,000 United States bo fumane hore mahloriso a serum magnesium a ne a amana haholo le CRP le lipalo tsa lisele tse t?oeu tsa mali, 'me maemo a CRP le IL-6 karolong e tlase ka ho fetesisa ea maemo a magnesium e ne e le 60% le 40% e phahameng ho feta ea quartile e phahameng ka ho fetisisa. Kamano e ne e le matla le ho feta ho batho ba batenya. Phuputso e 'ngoe ea batho ba 3,200 ho feta lilemo tse 65 e fumane hore maemo a serum magnesium a ne a amana hantle le bolelele ba telomere ea lisele tse t?oeu tsa mali 'me a amana hampe le maemo a CRP le D-dimer. Tlhahlobo ea meta ea liteko tse laoloang ka mokhoa o sa reroang tse 25 tse nang le boholo ba sampole ea batho ba fetang 2,000 e bont?itse hore tlatsetso ea magnesium ea molomo e fokolitse maemo a CRP ea serum ka karolelano ea 22%, TNF-α ka 15%, le IL-6 ka 18%. Ka hona, tlatsetso ea magnesium e ka liehisa botsofali ba 'mele ka litlamorao tse khahlanong le ho ruruha.

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Kamano ea taolo pakeng tsa magnesium le autophagy Autophagy ke mokhoa oa bohlokoa oa ho senyeha ha lisele le ho tlosoa ha liprotheine tse senyehileng le li-organelles, 'me e bohlokoa bakeng sa ho boloka homeostasis ea tikoloho ea cellular. Boithuto bo bonts'itse hore ts'ebetso ea autophagy e fokotseha butle butle nakong ea botsofali, mme bofokoli ba autophagy bo ka baka protheine aggregation, ho se sebetse ha mitochondrial, joalo-joalo, le ho potlakisa botsofali ba lisele. Magnesium, joalo ka len?osa la bobeli, e ameha ho laola ho qalisoa le ts'ebetso ea autophagy. Ka tomoso, khaello ea magnesium e thibela polelo ea liphatsa tsa lefutso tse amanang le autophagy Atg1 le Atg13 ka ho kenya t?ebetsong tsela ea mat?oao ea TORC1. Liseleng tsa mammalian, tikoloho e tlase ea magnesium e ka thibela ts'ebetso ea ULK1, Beclin1 le liprotheine tse ling tse qalang autophagy, le ho thibela ho thehoa ha li-autophagosomes. Liseleng tsa liphio tsa embryonic tsa motho, magnesium ion chelating agent EDTA e ka thibela phallo ea autophagy. Liteko tsa in vitro li bonts'itse hore physiological concentrations of magnesium ion e ka tlama le ho kenya t?ebetsong Atg4, enzyme ea proteolytic e hlokahalang bakeng sa kholo ea autophagosome. Lithuto tsa liphoofolo li boetse li fumane hore tlatsetso ea lijo tse itekanetseng tsa magnesium e ka fokotsa mathata a autophagy ho li-neuron le cardiomyocytes, ea ntlafatsa ts'ebetso ea kelello le ts'ebetso ea pelo ea systolic. Leha ho na le khaello ea bopaki bo tobileng ba kliniki, liphuputso tse ling tsa tlhokomeliso li fana ka maikutlo a kamano lipakeng tsa magnesium le autophagy. Maemo a Magnesium a ne a amana hantle le polelo ea mat?oao a autophagy Atg5 le Beclin1 liseleng tsa boko le lisele tsa mali a mononuclear a bakuli ba nang le lefu la Alzheimer's. Ho bakuli ba nang le lefu la tsoekere la mofuta oa 2, khatello ea magnesium ea serum e amana haufi-ufi le maemo a polelo a lefutso la autophagy LC3 le p62. Qetellong, magnesium e kanna ea bapala karolo ea bohlokoa ho haneleng botsofali ka ho laola autophagy. Empa mokhoa oa eona o khethehileng o hloka ho ithutoa ho ea pele.

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7. T?ebelisano pakeng tsa Magnesium le limela tsa mala a mala ke "setho" sa bohlokoa 'meleng oa motho, se phethang karolo e ke keng ea nkeloa sebaka ke metabolism ea phepo e nepahetseng, taolo ea 'mele ea ho it?ireletsa mafung, neuroendocrine le likarolo tse ling. Lipatlisiso tsa morao-rao li fumane hore liphetoho tse teng sebopehong le t?ebetsong ea gut microbiota li amana haholo le botsofali. Ka mohlala, karolo ea firmicutes le Bacteroides ka maleng a batho ba hōlileng e fokotsehile haholo, ha karolo ea likokoana-hloko tse nkang monyetla tse kang enterococcus le Staphylococcus e ntse e eketseha. Ho se leka-lekane hona ha limela ho ka baka t?enyo ho mokoallo oa mala, ho khothalletsa ho lokolloa ha mabaka a ho ruruha, le ho mpefatsa ho ruruha ho sa foleng 'meleng oohle.

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E le karolo ea bohlokoa ea limatlafatsi ka maleng, magnesium e ka ama sebopeho sa limela ka mekhoa e sa t?oaneng. Ho litoeba tse se nang likokoana-hloko, metsi a nooang a nang le magnesium a ka eketsa haholo palo ea libaktheria tse molemo tse kang bifidobacterium le Bacteroides, le ho fokotsa pH ea mala. Ka mohlala oa mouse oa colitis, magnesium supplementation e ile ea fokotsa t?itiso ea limela tsa mala 'me ea thibela ts'ebetso ea NF-κB tseleng ea ho ruruha. Litekong tsa batho ba phetseng hantle, karolo ea bifidobacteria mantleng e ile ea eketseha kamora libeke tse 8 tsa tlatsetso ea magnesium, mme maemo a lipopolysaccharide, D-lactic acid le metabolites tse ling tsa baktheria a fokotseha. Liphuputso tse ling tsa preclinical li fumane hape hore khaello ea magnesium e ka sitisa maqhama a thata a mala, ea eketsa ho kenella, le ho theha maemo a phetisetso ea li-endotoxin tsa enterogenic.

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Magnesium e ka boela ea ama ts'ebetso ea botsofali ea moeti ka ho laola metabolism ea baktheria. Ka mohlala, magnesium e susumetsa tlhahiso ea li-acid tse khut?oanyane tse nang le mafura a kang Bifidobacterium, e etsang hore ho be le G-protein-coupled receptor GPR43, e thibelang ho ruruha ho amanang le botenya le ho hanyetsa insulin. Ho feta moo, magnesium e ka boela ea ama bile acid le tryptophan metabolism, 'me mathata a litsela tsena tse peli a amana haufi le botsofali le mafu a neurodegenerative. Qetellong, magnesium e lebelletsoe ho ba leano le lecha la ho liehisa botsofali ka ho nchafatsa limela tsa mala le ho laola baktheria-gut-brain axis, empa litlamorao tsa eona tsa nako e telele li hloka ho netefatsoa ke liphuputso tse lebelletsoeng ho ba sehlopha.

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Ka kakaretso, palo e kholo ea bopaki ba liteko le epidemiological e bont?a hore magnesium ke limatlafatsi tsa bohlokoa ho hanela botsofali le ho khothalletsa bophelo bo botle le bophelo bo bolelele. E ameha taolong ea botsofali ka mekhoa e latelang:

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Le hoja liphello tsa tlatsetso ea magnesium ka nako ea bophelo ba motho ha e le hantle, bopaki bo sa tobang bo bont?a hore magnesium e ka thusa ho liehisa li-phenotype tse ngata tsa botsofali le ho ntlafatsa litebello tsa bophelo bo botle. Nakong e tlang, ho tla hlokahala lithuto tsa lihlopha tse lebeletsoeng le liteko tse laoloang ka mokhoa o sa reroang ho tsoela pele ho hlakisa liphello tse khahlanong le botsofali tsa magnesium le kamano ea eona ea tekanyo ea tekanyo, e le ho fana ka bopaki bo thehiloeng bopaking bakeng sa ho etsoa ha maano a tlatsetso ea magnesium. Ho feta moo, boemo ba phepo ea magnesium le tlhoko ea batho ba fapaneng ha li t?oane, kahoo ho hlophisoa ha lenaneo la tlatsetso ea magnesium le eona ke bothata bo potlakileng bo lokelang ho rarolloa. Ho lumeloa hore ka nts'etsopele ea meriana ea botsofali le phepo e nepahetseng, qetellong re tla senola liphiri tsohle tsa ntho ena ea boselamose ea magnesium, 'me re e sebelise ho loant?a botsofali le ho hlokomela toro ea bophelo bo botle ba nako e telele.

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