1. Mochini oa mantlha

baktheria metabolite glyoxylate

Libaktheria tse hanyetsanang le lithethefatsi li phahamisa polelo ea glyoxylate libakeng tse haelloang ke limatlafatsi, e fetolang likarolo tsa epigenetic, e fokolisa karabelo ea 'mele ea ho it?ireletsa mafung,' me e thusa libaktheria ho phela tlas'a khatello ea lithibela-mafu ka ho thibela ts'ebetso ea DNA demethylase (TET2) liseleng tse amohelang.

Vithamine C e kenya t?ebetsong t?ebetso ea enzyme ea TET2

Vithamine C, e le activator ea tlhaho ea TET2, e ka loant?a phello ea inhibitory ea glyoxylate ho it?ireletsa mafung, ho tsosolosa ts'ebetso ea DNA demethylation, le ho tsosolosa tsamaiso ea 'mele ea ho it?ireletsa mafung.

Ho senya leano la "lefu la bohata" la libaktheria

Acetaldehyde ka nako e ts'oanang e kenya ts'ebetso ea ts'ireletso ea libaktheria, e etsa liphehello ho qoba polao ea lithibela-mafu. Vithamine C e kopantsoeng le lithibela-mafu e ka senya phetoho ena ea metabolic le ho fokotsa boima ba baktheria haholo.

2. Bopaki ba liteko

Netefatso ea mohlala oa liphoofolo: Moetsong oa ts'oaetso ea litoeba, motsoako oa vithamine C le lithibela-mafu li ekelitse sekhahla sa ho pholoha ka 60%, tsa fokotsa bongata ba baktheria liseleng ka 80%, le maemo a fokotsehileng a ho ruruha ka 50%.

Synergistic effect: Vithamine C e ntlafatsa tsela ea pont?o ea interferon (IFN), e matlafatsa bokhoni ba sele ea 'mele ea ho it?ireletsa mafung ho tlosa libaktheria tse hanyetsanang le lithethefatsi, le ho thibela STAT1 dephosphorylation, ho lelefatsa karabelo ea 'mele ea ho it?ireletsa mafung.

3. Bokhoni ba kopo ea tleliniki

Ho hlōla bothata ba ho hanyetsa lithethefatsi: Leano lena le fana ka phekolo e ncha e sa it?etleheng ka lithibela-mafu bakeng sa mafu a baktheria a hananang le meriana a kang Salmonella le Mycobacterium tuberculosis, haholo-holo ho bakuli ba nang le t?oaetso ea khafetsa kapa lithibela-mafu tse sa sebetseng.

Morero oa phekolo o nolofalitsoeng: Vithamine C, e le limatlafatsi tse bolokehileng le tse theko e tlaase, li ka sebelisoa hammoho le lithibela-mafu tse teng ho fokotsa tekanyo ea lithethefatsi le ho fokotsa litla-morao.

Thibelo ea tlatsetso ea bohlokoa: Ho ja ka ho lekaneng ha limatlafatsi tse nyenyane (joaloka vithamine C) ho ka fokotsa ka tsela e sa tobang kotsi ea phetisetso ea liphatsa tsa lefutso tsa lithethefatsi ka ho boloka tekano ea gut microbiota.

4. Litaelo tsa lipatlisiso tsa nako e tlang

Lekola litlamorao tsa synergistic le motsoako o nepahetseng oa litekanyetso tsa vithamine C le lithibela-mafu tse ling tse kang beta lactam le quinolones.

Lekola phello ea tlatsetso ea nako e telele ea vithamine C ho iphetola ha libaktheria tse hananang le lithethefatsi.

Ho nts'etsapele lithethefatsi tse ncha tse thibelang likokoana-hloko tse shebileng glyoxylic acid-TET2 axis