Lycopene (LYC), carotenoid, ke pigment e qhibilihang ka mafura, e fumanoang haholo tamati, mahapu, grapefruit le litholoana tse ling, ke 'mala o ka sehloohong oa tamati e butsoitseng. Lycopene e na le melemo e fapaneng ea bophelo bo botle, ho kenyelletsa ho senya li-radicals tsa mahala, ho fokotsa ho ruruha, ho laola tsoekere le lipid metabolism, le litlamorao tsa neuroprotective.

Haufinyane tjena, Bafuputsi ba Univesithing ea Bongaka ea Shanxi ba ile ba hatisa pampiri koranteng ea Redox Biology e nang le sehlooho se reng "Lycopene e fokotsa bofokoli ba kelello bo amanang le lilemo ka ho kenya sebete-boko. Pampiri ea lipatlisiso ea fibroblast growth factor-21 signing ".

Liphuputso li bont?itse hore ho tlatsetsa ka lycopene bakeng sa likhoeli tsa 3 ho ka liehisa botsofali ba boko ho litoeba le ho fokotsa t?enyo ea kelello e amanang le lilemo, 'me lycopene e ntlafatsa ho senyeha ha neuronal, ho se sebetse ha mitochondrial, t?enyo ea synaptic, le ho khothalletsa fusion ea synaptic vesicle ho litoeba tse tsofetseng.

Ntle le moo, lycopene e kentse sebete-boko axis FGF21 e bonts'ang litoeba tse tsofetseng, ka hona e khothaletsa tokollo ea li-neurotransmitters ka ho eketsa maemo a ATP a mitochondrial le ho ntlafatsa fusion ea synaptic vesicular. Sena se fana ka maikutlo a hore FGF21 e ka 'na ea e-ba sepheo sa phekolo maqheka a ho kenella ka phepo e nepahetseng ho liehisa botsofali ba boko le ho ntlafatsa bokooa ba kelello bo amanang le lilemo.

Ha botsofali, botsofali ba boko, ho se sebetse ha mitochondrial ke e 'ngoe ea lintlha tsa bohlokoa ka ho fetisisa, bafuputsi ba fumane hore lycopene supplementation e ka ntlafatsa t?enyo ea mitochondrial morphological, le ho fetola boemo ba ketane ea lipalangoang tsa elektronike ea mitochondrial e bakoang ke botsofali, e khothalletsa tlhahiso ea ATP, e bont?ang hore ts'ebetso ea lycopene e na le phello ea t?ireletso ho mito.

Qetellong, bafuputsi le bona ba ile ba etsa liteko tsa in vitro mme ba fumana hore lycopene e ntlafatsa bokhoni ba lisele tsa sebete ho ts'ehetsa li-neurone, ho kenyelletsa ho ntlafatsa botsofali ba lisele, ho ntlafatsa ts'ebetso ea mitochondrial, le ho eketsa bolelele ba neuron axon.

Ha li kopane, liphetho li fana ka maikutlo a hore tlatsetso ea lycopene e ka liehisa botsofali ba boko le ho thibela bokooa ba kelello bo amanang le lilemo ho litoeba, ka karolo e itseng hobane lycopene e etsa hore ho be le pont?o ea hepato-brain axis FGF21, e fana ka maikutlo a hore FGF21 e ka 'na ea e-ba sepheo sa phekolo ea mekhoa ea phepo e nepahetseng ho ntlafatsa mafu a kelello a bakoang ke lefu la kelello le fokolisang kelello.