Citicolinee 'nile ea sebelisoa haholo mekhoeng ea bongaka, haholo-holo bakeng sa phekolo ea sequelae ea methapo ea kutlo e bakoang ke kotsi ea craniocerebral kapa kotsi ea cerebrovascular,' me e fumane t?ebeliso e ncha mekhoeng ea bongaka. Kalafo ea eona ea ho tsoa mali bokong, lefu la Parkinson, glaucoma, lefu la tsoekere la peripheral neuropathy le tinnitus le mafu a mang le eona e hohetse tlhokomelo e ntseng e eketseha. Joale citicoline ke eng, ke liphello life tsa pharmacological, lipont?o tsa eona (phekolo e khethehileng ea mafu afe), katleho le polokeho?

Citicoline ke nucleotide e le 'ngoe e entsoeng ka ribose, cytosine, pyrophosphate le choline. Ke endogenous nucleotide ea 'mele oa motho. E ameha litseleng tse ngata tsa bohlokoa tsa metabolism 'meleng. Ke selelekela sa tlhaho sa phospholipid synthesis ea neuron cell membrane sebopeho le selelekela sa biosynthesis ea neurotransmitter acetylcholine.

Citicoline ke ntho e sireletsang methapo ea kutlo e ka sireletsang li-neurone tse tlokotsing, ka hona e fokotsa kapa ea thibela tsoelo-pele ea mafu. Hajoale, li-neuroprotective agents tse sebelisoang hangata litsing tsa bongaka li kenyelletsa calcium channel blockers, glutamate antagonists, free radical scavengers, le cell membrane stabilizers, tseo citicoline e leng karolo ea cell membrane stabilizers.

Citicolinee na le litlamorao tse ngata tsa pharmacological, 'me mekhoa ena ea ts'ebetso e etsa hore e be le monyetla o moholo oa ts'ireletso ea methapo le ho lokisoa ha methapo. E na le phello ea ts'ireletso ea methapo ea ho thibela ho hlaha ha kotsi ea neuronal le phello ea ho lokisa methapo ka mor'a hore ho be le kotsi ea neuronal, e leng ho atolosa fensetere ea nako ea phekolo ea citicoline.

Ho ipapisitsoe le thepa ea eona ea litlama, citicoline e sebelisoa haholo kalafong ea setorouku, ho holofala ha kelello, kotsi e sithabetsang ea boko, lefu la Parkinson, glaucoma, lefu la tsoekere la peripheral neuropathy, tinnitus le mafu a mang, 'me katleho ea eona le polokeho li netefalitsoe lithutong tse ngata tsa bongaka, ka bopaki bo lekaneng ba bopaki ba bongaka. Stroke: stroke ke mofuta oa thipa ea cerebral vascular blockage kapa ho phatloha, e bakang t?enyo ea boko ea sehlopha sa mafu, ho kenyelletsa ischemic le hemorrhagic stroke, eo ischemic stroke e leng mofuta o ka sehloohong oa stroke, e nkang karolo ea 75 ho isa ho 90% ea lichapo tsohle. Kotsi ea bophelo bohle ea stroke ho baahi ba rona ke 35% -40.9%, e boemong ba pele lefat?eng, eseng feela, stroke e boetse e le sesosa sa pele sa lefu le bokooa ho baahi ba rona.

Bopaki ba lipatlisiso tsa kliniki:

1. Ka 2002, American Journal Stroke e ile ea hatisa tlhahlobo ea meta-analysis ea liteko tsa kliniki ho bakuli ba nang le acute ischemic stroke, e bont?ang hore oral citicoline e eketsa monyetla oa hore bakuli ba stroke ba fole ka mor'a likhoeli tse 3 [1].

2. Ka 2009, ho ile ha etsoa liteko tsa lipatlisiso tsa ho hlahloba lithethefatsi Korea Boroa bakeng sa bakuli ba 4191 ba nang le lefu le matla la ischemic, 'me liphello li bont?itse hore citicoline e ntlafalitse lintlha tsa NIHSS le palo ea BI ea bakuli ba nang le melemo ea phekolo ea pele le ea morao-rao, le melemo ea nako e telele ea kopo e ne e le kholoanyane,' me phello ea phekolo e ne e amana hantle le tekanyo. Ntlafatso e ne e le ea bohlokoa haholo sehlopheng sa litekanyetso tse phahameng (≧2000mg / letsatsi), 'me kopo ea nako e telele e ne e sireletsehile ebile e mamelloa [2].

3. Liphello tsa liphuputso tsa lifofane tse ngata, tse sa tloaelehang, tse peli tse foufetseng, tse laoloang ke placebo ka boko ba mali li fana ka maikutlo a hore citicoline ke sethethefatsi se sireletsehileng bakeng sa ho phekoloa ha lefu la boko le phello e ntle ea phekolo [3].

4. Phuputso e bulehileng, e sa tloaelehang, e t?oanang e ile ea hlahloba phello ea citicoline ka ho senyeha ha kelello ka mor'a lefu la stroke, 'me liphello li bont?itse hore t?ebeliso ea nako e telele ea citicoline e ntlafalitse haholo ho senyeha ha kelello ka mor'a stroke [4].