Botsofali ke mokhoa o rarahaneng, oa mekhahlelo e mengata, o etsahalang butle-butle bophelong bohle. Ha nako e ntse e feta, litho le mesifa ea 'mele oa motho li tla tsofala butle-butle,' me maloetse a mang a tla boela a hlahe ka ho hōla ha lilemo, ho akarelletsa kankere, lefu la tsoekere, mafu a pelo le tse ling.

Liphuputso tse ntseng li eketseha li bont?itse hore li-phytochemicals, tse akarelletsang polyphenols, flavonoids, terpenoids, joalo-joalo, li ka lelefatsa bophelo bo botle ka ho thibela oxidation, ts'ebetso ea mitochondrial autophagy le mekhoa e meng, 'me e na le thepa e khahlanong le botsofali.

Pejana, bafuputsi ba fumane hore sage extract e ka liehisa liteko tsa botsofali in vitro, 'me ho litoeba le mehlala ea batho ba in vitro, sage extract e fokolitse haholo palo ea lisele tsa beta-galactose sidase tse amanang le botsofali, tse bonts'ang thepa ea anti-botsofali.

Haufinyane tjena, Bafuputsi Univesithing ea Padova Italy ba phatlalalitse pampiri koranteng ea Nature Aging e nang le sehlooho se reng "Targeting senescence e bakoang ke lilemo kapa chemotherapy e nang le polyphenol-rich. tlhahiso ea tlhaho e ntlafatsa nako e telele le bophelo bo botle ho litoeba."

Liphuputso li bont?itse hore ho noa letsatsi le leng le le leng la sesepa sa sage ho ka eketsa nako ea bophelo le bophelo bo botle ba litoeba, ho thibela ho ruruha ho bakoang ke lilemo, fibrosis le mat?oao a botsofali ka har'a mefuta e sa t?oaneng ea lisele, le ho ntlafatsa phenotypes ea botsofali.

Phuputsong ena, bafuputsi ba ile ba hlahloba matla a ho thibela botsofali a sage extract (HK) ka vivo ka mefuta ea litoeba, ka ho eketsa litekanyetso tse tlaase tsa HK ho metsi a nooang letsatsi le leng le le leng, le ho hlahloba ho bokellana ha lisele tsa lisele ka mefuta ea litoeba, hammoho le likarolo tse 'maloa tse amanang le lilemo, ho akarelletsa le nako e telele, bophelo bo botle ba' mele, fibrosis, masapo a masapo le ho ruruha.

Bafuputsi ba ile ba fa litoeba tsa likhoeli tse 20 metsi a nooang a nang le HK ho fihlela li e-shoa.

Liphello li bont?itse hore nako e tloaelehileng ea bophelo ba litoeba sehlopheng sa phekolo ea HK ??e ne e le likhoeli tsa 32.25, ha nako e tloaelehileng ea bophelo ba litoeba sehlopheng sa taolo e ne e le likhoeli tsa 28 feela. Kalafo ea HK ??e ile ea eketsa nako ea bophelo ka likhoeli tse 4.25, 'me nako ea bophelo ea litoeba tse t?ehali le tse tona e ile ea atolosoa haholo.

Tlhahlobo ea histopathological ea letlalo, sebete, liphio le mat?oafo a litoeba li fumane hore phekolo ea HK ??ha ea ka ea baka liphetoho ho li-parameter tsa hematopoietic kapa chefo ea setho, e bont?ang hore phekolo ea HK ??e sireletsehile.

Ntle le moo, kalafo ea HK ??e ntlafalitse li-phenotypes tsa botsofali ho litoeba ha li bapisoa le taolo, ho kenyelletsa le likarolo tsa hunchback, nts'etsopele ea hlahala le boemo ba boea ba liphoofolo.

Liphetho tsena li bonts'a hore kalafo ea HK ??e ka lelefatsa bophelo bo botle le bophelo bo bolelele ba litoeba, 'me ha ho chefo e bonoang.

Tlhahlobo e eketsehileng e fumane hore phekolo ea HK ??e ntlafalitse li-phenotypes tsa botsofali mefuteng e sa t?oaneng ea lisele, ho akarelletsa le ho lahleheloa ke moriri o ntlafetseng, masapo, bophelo bo botle ba mesifa le mosebetsi oa liphio.

Tlhahlobo ea mekhoa e bont?itse hore phekolo ea HK ??e theohile haholo-e laola liphatsa tsa lefutso tsa botsofali SAUL_SEN_MAYO, ha liphatsa tsa lefutso tse tsofalang li ne li amahanngoa le ho ruruha ho feteletseng, ts'ebetso ea 'mele ea ho it?ireletsa mafung, le litsela tse amanang le lilemo, ho fana ka maikutlo a hore phekolo ea HK ??e fetotse likarolo tsa transcriptome tse amanang le ho ruruha le botsofali. Ho feta moo, tlhahlobo ea mesifa, letlalo, liphio le mat?oafo li fumane hore phekolo ea HK ??e fokolitse litekanyetso tsa mat?oao a botsofali liseleng tse fapaneng tsa 'mele.

Ntle le botsofali ba tlhaho, bafuputsi ba fumane hape hore kalafo ea HK ??e ka boela ea thibela botsofali le cardiotoxicity e bakoang ke chemotherapy drug doxorubicin, ha e ntse e boloka phello ea eona ea kalafo.

Qetellong, hobane HK ke motsoako o nang le mefuta e sa t?oaneng ea limela, bafuputsi ba ile ba hlahloba lisebelisoa tse khethehileng tse phethang karolo e khahlanong le botsofali, 'me liphello li bont?itse hore karolo ea flavonoid, luteolin (Lut), ke motsoako o sebetsang oa HK anti-botsofali, e ntlafatsang botsofali ka ho fetola ho sebelisana pakeng tsa p16 le CDK6.

E kopantsoe hammoho, thuto e fumane tlhahiso ea tlhaho e nang le liphello tse khahlanong le botsofali tse ntlafalitseng botsofali ba lisele le lisele, mat?oao a ntlafetseng a lilemo tse kang boea, humpback, ho bokella mat?oao a botsofali le t?enyo ea DNA liseleng, le nako e telele ea bophelo ba liphoofolo.