SAIB(sucrose isobutyrate acetate) ke sehlopha sa meriana se thusang ka mesebetsi e mengata. Ke mokelikeli oa viscous o lokiselitsoeng ke esterification e laoloang ea tsoekere ea tlhaho (sucrose) e nang le acetic acid le isobutyric anhydride. Ke motsoako o hlahisoang ke distillation le tlhahiso e hloekisitsoeng haholo. E ka sebelisoa e le thepa e tsitsitseng ea ho lokolla, solvent / carrier le inhibitor ea t?ebeliso e mpe ea lithethefatsi.

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Lit?obotsi tsa sehlahisoa sa SAIB

SAIB ke solvent/carrier e babatsehang bakeng sa hydrophobic API mme e na le ts'ebetso ea ho lokolla butle.

SAIB ha e khanye 'me e lula e le amorphous mocheso oa kamore, e leng se khothalletsang haholo tekanyo e sa khaotseng ea ho fana ka lithethefatsi;

SAIB ha e na polymeric 'me ha e hoama kapa ho na pula ha e kopana le maro a 'mele a nang le metsi. SAIB e qhibiliha ka har'a metsoako e mengata ea tlhaho 'me e lumellana le lisebelisoa tse ngata; SAIB e ka qhalakanwa ka metsing ka thuso ya dihlapolli tsa tlhaho.

SAIB e na le lisebelisoa tsa bioadhesive 'me e ka sebelisoa bakeng sa lisebelisoa tsa transdermal, sublingual le buccal patch.

Sesebelisoa sa sehlahisoa

1. Ho lieha ho lokolloa

Set?oant?ong se ka holimo, ho ka bonoa hore SAIB e na le boleng ba HLB bo ka bang 5, e leng se bont?ang hore ke hydrophobic.

2. Tharollo e mpe ea API ea ho qhibiliha ha metsi

Hydrophobic SAIB ke solvent/carrier e ntle bakeng sa API e nang le metsi a fokolang a qhibilihang, 'me t?ebeliso ea SAIB e ntlafatsa ho qhibiliha ha lithethefatsi tse sa tsitsang khoebong.

3. Thibela t?ebeliso e mpe ea lithethefatsi

T?ebeliso ea SAIB e eketsa boholo ba li-opioid nakong ea ho sila le ho sitisa ho nt?oa ha lithethefatsi.

(1) Li-polymers (polyoxyethylene le / kapa hydroxypropyl methylcellulose) le tocopherol acetate ke li-granules tse entsoeng ka tharollo ea joala ea SAIB. Litokisetso li khethiloe e le tse sa Phekolohang / Tse sa Phekolehang kapa Tse Fokotsoeng ka Mocheso / Phekotsoe (Ho Fokotse 90oC metsotso e 30).

(2) Pseudoephedrine hydrochloride, polymers (polyoxyethylene le / kapa hydroxypropyl methylcellulose) le tocopherol acetate ke li-granules tse entsoeng ka tharollo ea joala ea SAIB. Litokisetso li khethiloe e le tse sa Phekolohang / Tse sa Phekolehang kapa Tse Fokotsoeng ka Mocheso / Phekotsoe (Ho Fokotse 90oC metsotso e 30).

Tlhahlobo ea tlhekefetso ea nko e bont?itse hore t?ebeliso ea SAIB e ekelitse boholo ba phofo nakong ea ho sila, ho fihlela ho 47% ea boholo ba phofo e silang ho feta 1mm.

Ha ho bapisoa le sehlopha sa taolo, palo ea ho nt?oa ha SAIB ka metsing, 0.1% N HCl le 0.1% N NaOH e theohile ka 41.3% -42.5%, 24.8% -26.1% le 37.4% -50.6%, ka ho latellana. T?ebeliso ea lihlapolli tsa tlhaho bakeng sa ho nt?oa e hlahisa mesaletsa e khomarelang eo ho leng thata ho feta litseleng tse fapaneng tsa tsamaiso (mohlala, ente, ho noa, ho hula, joalo-joalo), ho thibela t?ebeliso e mpe ea lithethefatsi.

sephetho

T?ebeliso ea SAIB, ntle le ho roala, e ka kopanngoa ka ho toba le API ho lelefatsa ho lokolloa ha lithethefatsi le ho finyella tokollo e tsitsitseng.

Hydrophobic SAIB, e ka qhalakantsoeng ka metsing ka thuso ea li-solvents, e ka sebelisoa ka hydrophobic kapa hydrophilic apis; SAIB e ka ntlafatsa ho qhibiliha ha API ka ho qhibiliha ho fokolang ha metsi 'me ke sehlaseli se setle le se tsamaisang API se nang le metsi a fokolang.

T?ebeliso ea SAIB e thibela t?ebeliso e mpe ea lithethefatsi ka ho eketsa boholo ba karoloana ea lithethefatsi ha e le fat?e, ho kena-kenana le ho nt?oa ha lithethefatsi, le ho etsa hore ho be thata hore sethethefatsi se kenelle ka litsela tse fapaneng tsa tsamaiso.

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