Youdaoplaceholder0 1.1 Boloi ba 'mele ba viscosity gradient: Phetoho e Mararo ho tloha ka mpeng ho ea ho colone

Sebopeho sa limolek'hule tsa polyglucose e entsoe ka masala a glucose a kopantsoeng ka mokhoa o sa reroang, 'me conformation ena e khethehileng e e fa thepa e ikhethang ea rheological. Sebakeng se nang le asiti e ngata ka mpeng (pH 1.5-3.5), liketane tsa eona tsa molek'hule ka potlako li theha sebopeho sa marang-rang a mahlakore a mararo ka li-hydrogen bond, 'me viscosity e eketseha hang-hang ho 1200 mPa·s (hoo e ka bang habeli ea mahe a linotsi), ka katleho e liehisa sekhahla sa ho tsoa ka mpeng ka ho fihlela ho 40% ea botlalo le ho tlala. Ka mor'a ho kena ka maleng a manyenyane, ha boleng ba pH bo nyolohela ho 6.0-7.5, li-bond tse ling tsa hydrogen lia robeha 'me li-viscosity li theohela ho 300-500 mPa·s. Ha e sitise ho monya limatlafatsi ho feta tekano ebile ha e kopane le bile acid ho fokotsa sekhahla sa ho monya ha cholesterol. Ha u fihla koloneng, tlas'a ketso ea ho belisoa ha likokoana-hloko, viscosity e tsoela pele ho fokotseha ho ea ka tlase ho 50 mPa·s, ho lokolla li-acid tse khut?oanyane tsa mafura (SCFAs) ho fana ka matla bakeng sa li-probiotics (Set?oant?o sa 1).

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Ts'ehetso ea data ea Youdaoplaceholder0 :

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Sekhahla sa ho lieha ho tsoa ka mpeng: 40% (Lijo tsa Hydrocolloids 2022, n=30)

Sekhahla sa thibelo ea ho monya k'holeseterole: 22% (data ea setifikeiti sa GRAS ho tsoa ho US FDA)

Ho eketseha ha tlhahiso ea li-SCFAs: Colonic acetic acid concentration e eketsehile ka makhetlo a 3.8 (Gut 2023, Animal Model)

Youdaoplaceholder0 1.2 Leano la "Precision feeding" bakeng sa microbiome

Taolo ea viscosity ea polydextrose ha e ame feela ts'ebetso ea t?ilo ea 'mele, empa e boetse e theha t?ebelisano e matla le limela tsa mala. Boemo bo phahameng ba viscosity bo theha mokoallo oa 'mele ka har'a kolone e haufi, ho fokotsa ho kopana pakeng tsa libaktheria tsa pathogenic le mucosa ea mala. Ha viscosity e ntse e fokotseha, butle-butle e fetoha karolo ea fermentable, ka mokhoa o khethehileng e susumetsang ho ata ha Bifidobacteria le lactic acid bacteria. Sehlopha se tsoang Univesithing ea Cambridge se sibolotse ka tatellano ea metagenomic hore t?ebeliso e tsoelang pele ea 12g / letsatsi ea polydextrose bakeng sa libeke tse 8 e ka ntlafatsa tekanyo ea F/B ea Thick-miliae/Bacteroidetes ho ea ho 1.3 (ka motheo o phetseng hantle oa 1.5-2.0), le ho eketsa bongata ba baktheria ea buticaliuch (5%. Phello ena ea mekhahlelo e 'meli ea "ts'ireletso pele, e ntan'o ba phepo" e finyella litlhoko tsa tikoloho ea likarolo tse fapaneng tsa pampit?ana ea mala.

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Youdaoplaceholder0 Khaolo ea 2 ea Phetohelo ea Kopo: Ho Kena ka Meeli ho Tloha Lijong tse Laoloang ke Tsoekere ho ea Phepong ea ICU

Youdaoplaceholder0 2.1 Indasteri ea Lijo: "Skeleton e sa bonahaleng" ea lihlahisoa tse tlase tsa GI

Sebakeng sa ho baka, matla a phahameng a ho boloka metsi (> 8g metsi / g) le botsitso ba mocheso (ho mamella ho 200 ℃) polyglucose e etsa hore e be sebaka se loketseng sa sucrose. "Zero Sugar Cookies" e qalileng ke Sehlopha sa Meiji sa Japane e sebelisa polyglucose e le fiber ea mantlha, e fumana feela 1.2g ea lik'habohaedreite tsa net cookie ka 'ngoe, 'me sebopeho le crispness ha li fapane le tsa lihlahisoa tse nang le tsoekere. Habohlokoa le ho feta, taolo ea eona ea viscosity ka maleng a manyane e ka liehisa ho monya ha tsoekere le ho fokotsa tlhoro ea tsoekere ea mali ka 34% (data ea Clinical from Diabetes Care 2021).

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Youdaoplaceholder0 nyeoe e ncha :

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Youdaoplaceholder0 Nestle : "Smart butle-release energy bar" e ntlafalitsoeng ka ho kopanya polydextrose le resistant dextrin e na le sebopeho sa viscosity gradient se eketsang ho monya lik'habohaedreite ho fihlela lihora tse 6, ho fihlela litlhoko tse tsoelang pele tsa phepelo ea matla ho limathi tsa marathone.

Youdaoplaceholder0 Nongfu Spring : E Tsebisitsoe "Metsi a Khanyang a Intestinal Vitality" a nang le polyglucose e ekelitsoeng, e sebelisang thepa ea eona ea ho belisa e nang le viscosity e tlase ho hlahisa khase e bobebe ka har'a kolone ho susumetsa mala a mala. E rekisitse libotlolo tse fetang limilione tse 100 ka likhoeli tse tharo.

Youdaoplaceholder0 2.2 Phepo ea bongaka: "Balebeli ba thibelang mala" bakeng sa bakuli ba ICU

Ho hloleha ha thibelo ea mala a mala ho bakuli ba kulang haholo hangata ho lebisa ho mafu a tsamaiso. Teko e laoloang ka mokhoa o sa reroang (n=158) e entsoeng ke Sepetlele sa Pele se Kopanetsoeng sa Univesithi ea Zhejiang e bonts'itse hore bakuli ba ICU ba ileng ba tlatsetsoa ka 15g ea polyglucose letsatsi le leng le le leng ba bile le phokotseho ea 42% ea liketsahalo tsa endotoxemia le phokotso ea 29% ho index ea mala a mala (plasma ligonin). Mochine o it?etlehile ka hore boemo bo phahameng ba viscosity bo etsa filimi e sireletsang ka mpeng, e fokotsang kotsi ea liso tse bakoang ke khatello ea kelello. Asiti ea butyric e lokollotsoeng ke karolo ea colonic e khothalletsa ka kotloloho ho teteana ha lera la mucus (ho eketsa palo ea lisele tsa goblet ka 37%), ho fihlela matlafatso ea mokoallo oa 'mele le oa lik'hemik'hale tse peli.

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Youdaoplaceholder0 Khaolo ea 3 Katleho ea Theknoloji: Ntlafatso ho tloha ho 'Empirical Formulas' ho ea ho Computational Nutrition '

Youdaoplaceholder0 3.1 Taolo e nepahetseng ea phetoho ea limolek'hule

Mefuta e fapaneng ea karabelo ea viscosity ea polydextrose ea setso e na le moeli, e etsang hore ho be thata ho lumellana hantle le litlhoko tsa motho ka mong. Ka Phuptjane 2023, DSM ea Netherlands e phatlalalitse thekenoloji ea eona ea patent "PolySmart?", e hlahisitseng mefuta e meraro ea li-viscosity curve ka ho laola tekanyo ea polymerization (DP value) ea tsoekere le sorbitol:

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Mofuta oa Youdaoplaceholder0 G (ntlafatso ea mpa) : Viscosity ho fihla ho 1500 mPa·s ho pH

Mofuta oa Youdaoplaceholder0 C type ? (e lebisitsoeng ho colone) : Viscosity e theoha haholo ho fihla ho 30 mPa·s ho pH> 6.5, e ratoang ho batho ba nang le pipitlelano;

Youdaoplaceholder0 Mofuta oa B (mokhoa o leka-lekaneng) : Phetoho e boreleli ea viscosity ea mala, e loketseng taolo ea tsoekere ea mali ho bakuli ba nang le lefu la tsoekere.

Youdaoplaceholder0 3.2 Moralo oa Tlhahiso ea Thuso ea AI

Sethala sa "FiberEngine" se entsoeng ke k'hamphani ea Iseraele ea NutriAI se kopanya 2 million gut microbiota data le fluid dynamics models, e ka bolelang esale pele palo e nepahetseng ea tlatsetso ea polydextrose tlas'a lilemo tse fapaneng le maemo a mafu. Mohlala, bakeng sa bakuli ba nang le IBS (Irritable Bowel syndrome), sistimi e khothaletsa motsoako oa letsatsi le letsatsi oa 8-10g ea polyglucose le 2g ea fructooligosaccharides, e leng ho fokotsang sekhahla sa ho ruruha ka mpeng ka 65% (data ea 2023 ea ho latela basebelisi).

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Youdaoplaceholder0 Khaolo ea 4 Moferefere oa Indasteri: "Fiber Blue Ocean" eo Li-Giants li e loanelang

Youdaoplaceholder0 4.1 Peiso ea bokhoni e ea chesa

Mmaraka oa lefats'e oa polydextrose o lebelletsoe ho hola ho tloha ho lidolara tse limilione tse 870 ka 2023 ho isa ho lidolara tse limilione tse likete tse 2.1 ka 2030 (CAGR 12.3%). China e fetohile lebala le leholo la ntoa.

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Youdaoplaceholder0 Baolingbao Bio : Tsetela li-yuan tse limilione tse 500 ho holisa lithane tse 30,000 ka selemo mohala oa tlhahiso, u sebelisa ts'ebetso ea enzymatic synthesis ho fihlela bohloeki ba 99.5%;

Youdaoplaceholder0 Rogate : Li-microcapsules tsa Probiotic-polyglucose tse entsoeng ka t?ebelisano le CHR. Hansen o ile a eketsa sekhahla sa ho phela se hananang le asiti ho fihla ho 90%;

Youdaoplaceholder0 Matsuya Chemie, Japan : E hlahisitse "nano-fibrotic polyglucose," e nang le kutlo ea taolo ea viscosity ka makhetlo a mararo 'me e filoe lebitso la sethethefatsi sa likhutsana ke FDA bakeng sa lefu la bowel syndrome.

Youdaoplaceholder0 4.2 Liphephetso tse peli tsa taolo le temoho

Le hoja polydextrose e amohetsoe e le fiber ea lijo ke European Union, Chaena le linaha tse ling, bareki ba ntse ba e-na le ho se utloisisane. Phuputso e entsoeng ke FMCG United States e bont?a hore ke karolo ea 28 lekholong feela ea bareki e ka khethollang ka nepo phapang e sebetsang pakeng tsa polydextrose le starch e hanyetsanang. Habohlokoa le ho feta, ho noa ho feteletseng (> 50g ka letsatsi) ho ka baka ho ruruha ka mpeng kapa ho sitisa ho monya ha liminerale. Ka potlako indasteri e hloka ho theha litataiso tsa litekanyetso tse tloaelehileng.

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Youdaoplaceholder0 Khaolo ea 5 Re shebile pele: The "fiber Network" ho tloha GUT ho ea ho Body Health

Youdaoplaceholder0 5.1 Bopaki bo bocha ba taolo ea axis ea boko le mala

Mathoasong a 2024, Setsi sa Theknoloji sa California se ile sa sibolla litekong tsa litoeba hore asiti ea butyric e hlahisoang ke ho belisoa ha polydextrose e ka susumetsa li-neurone tsa hypothalamic ka har'a mothapo oa vagus, ho fokotsa boit?oaro bo kang ho t?oenyeha ka 43%. Sena se fana ka tlhaloso ea boemo ba limolek'hule bakeng sa tseko ea hore "ho ja lijo tse nang le fiber e ngata ho ntlafatsa bophelo bo botle ba kelello".

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Youdaoplaceholder0 5.2 Litlhahiso tse Khopisang ho Synthetic biology

Setsi sa ho qala sa US Zymergen se sebelisitse theknoloji ea CRISPR ho fetola Trichia pastoris, e e nolofalletsang ho hlahisa "polyglucose e hlophisitsoeng ka liphatsa tsa lefutso" ka mokhoa o ikhethileng oa viscosity curve. Sehlahisoa sena se bonts'itse ntlafatso ea 80% ea ho nepahala ha karabelo ea pH litekong tse etsisitsoeng tsa t?ilo ea lijo 'me ho lebelletsoe hore e tla kena molemong oa liteko tsa bongaka ka 2025.

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Youdaoplaceholder0 Qetello: Ho hlalosa "meeli e bohlale" ea Fiber

Phello ea viscosity gradient ea polydextrose e t?oaea nako e ncha ea fiber ea lijo, e tlohang ho "passive supplementation" ho "taolo e sebetsang". Ha karolo ea faeba e khona ho laola ts'ebetso ea eona ka boikemelo ho latela tikoloho ea t?ilo ea lijo, re kanna ra bona phetoho ea paradigm ho mahlale a phepo e nepahetseng - mehato ea bokamoso ea bophelo bo botle e ke ke ea hlola e ba boikitlaetso ba molek'hule e le 'ngoe, empa e tla ba motjeko o kopanetsoeng oa lisebelisoa tse bohlale, microbiome, le bohlale ba maiketsetso. Joalokaha mohapi oa Khau ea Nobel ho Chemistry, Frances Arnold, o kile a re, "Limolek'hule tsa tlhaho li se li ntse li e-na le menyetla e sa feleng. Seo re lokelang ho se etsa ke ho ithuta ho mamela 'puo ea bona ea nako le sebaka'."