Bokhoni ba mannose lefapheng la meriana bo tsepamisitsoe haholo-holo ka litsela tse 'maloa tse khethehileng, tseo tse ling tsa tsona li seng li sebelisitsoe ka mokhoa oa bongaka (joaloka thibelo ea t?oaetso ea moroto), ha tse ling li le lipatlisisong tsa motheo kapa sethaleng sa liteko tsa pele tsa bongaka. Litebello li t?oanela ho ela hloko, empa ho hlokahala bopaki bo eketsehileng ho li t?ehetsa. Hlalosa bokhoni ba eona libakeng tse latelang:

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1, Maemo a Kopo a Tsebahalang/Ba Hlileng Matla

Ho thibela mafu a iphetang a moroto (rUTI) ?

Mokhoa: Tsamaiso ea molomo ea mannose e fella ka ho tsoa haholo ka har'a moroto, ka tlholisano e thibela ho tlamaha ha li-adhesin tsa FimH pilin ho tsoa ho likokoana-hloko tse kang Escherichia coli ho ea liseleng tsa senya, ho thibela libaktheria hore li se ke tsa ikakhela le ho hlatsuoa ke moroto.

Bopaki:

Liphuputso tse ngata tsa kliniki, tse kang ho bapisoa le furantoin ea lithibela-mafu, li bont?itse hore 1.5-2g ea mannose ka letsatsi e sebetsa hantle joaloka lithibela-mafu tse fokolang ho thibela rUTI e bakoang ke Escherichia coli ho basali, 'me e na le kotsi e fokolang ea ho hanyetsa.

Litaelo tsa European Association of Urology (EAU) li e thathamisa e le mokhoa o mong oa thibelo ea rUTI (Boemo ba Bopaki: B).

Melemo: Polokeho e phahameng (litla-morao tse bobebe tsa mala), ha ho kotsi ea ho hanyetsa lithibela-mafu ka bongata.

Meeli: E sebetsa feela bakeng sa thibelo 'me e ke ke ea nkela lithibela-mafu sebakeng sa phekolo ea t?oaetso e matla; Phello ho non Escherichia coli UTI e lekanyelitsoe.

2, Libaka tse sethaleng sa lipatlisiso empa tse nang le bokhoni bo hlakileng

Kalafo ea Congenital Glycation Disorder (CDG)

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Mechanism: Mefuta e meng ea CDG, e kang MPI-CDG (CDG-Ib type), ha e na phosphomannose isomerase (PMI), e thibelang phetoho ea mannose-6-phosphate ho fructose-6-phosphate, e lebisang ho se sebetse ha litho tse ngata.

Kalafo: Tsamaiso ea molomo ea mannose e ka feta bofokoli ba PMI mme ka ho toba e fana ka mannose-6-phosphate, ho tsosolosa motsoako oa glycoprotein.

Boemo ba hajoale:

FDA e amohetse t?ebeliso ea mannose bakeng sa MPI-CDG, e leng e 'ngoe ea mefuta e fokolang e phekolehang ea CDG.

Ntlafatso e kholo ea lefu la sebete, ho se sebetse ha coagulation, le mat?oao a mala, empa ho hlokahala meriana ea bophelo bohle.

Monyetla: Lekola boleng ba kalafo ea adjuvant bakeng sa mefuta e meng ea CDG, joalo ka ALG-CDG.

Taolo ea 'mele ea ho it?ireletsa mafung ea antitumor le phano ea lithethefatsi ???? (Phuputso e sebetsang ea preclinical)

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Mokhoa:

Sebaka se lebisitsoeng sa tumor microenvironment: Tumor a amanang le macrophages (TAMs) e hlalosang haholo mannose receptors (MRC1), le lithethefatsi tse fetotsoeng tsa mannose li ka isoa lihlahala ka mokhoa o lebisitsoeng.

Ho laola khatello ea 'mele ea ho it?ireletsa mafung: Mannose ka tlholisano e thibela li-receptor tsa mannose holim'a li-TAM, e thibela ho lemoha ha tsona li-antigen tsa mannose glycated holim'a lisele tsa hlahala, tse ka fetolang khatello ea 'mele ea ho it?ireletsa mafung.

Ho matlafatsa kutloisiso ea chemotherapy: Lithutong tsa liphoofolo, motsoako oa mannose le chemotherapy (joalo ka doxorubicin) o ka thibela haholo kholo ea hlahala (mohlomong ka ho kena-kenana le metabolism ea tsoekere).

Phephetso: Ho hlokahala lipatlisiso tse ling mabapi le katleho ea batho, litekanyetso tse nepahetseng, le litsamaiso tsa phano.

Li-adjuvants tsa t?oaetso ea antifungal/antiparasite ??

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Mechanism: Likokoana-hloko tse kang Candida albicans le Plasmodium li it?etlehile ka li-receptor tsa mannose tse amohelehang ho hlasela lisele. Mannose e ka thibela ho khomarela ha eona.

Patlisiso:

Mefuta ea in vitro le ea liphoofolo e bont?itse hore mannose e ka thibela Candida ho khomarela lisele tsa epithelial.

T?ebeliso e kopantsoeng le meriana e thibelang malaria e ka fokotsa sekhahla sa t?oaetso ea likokoana-hloko tsa malaria (liteko tsa liphoofolo).

Monyetla: E le tlatsetso ea ho matlafatsa ts'ebetso ea litlhare tse seng li ntse li le teng tse thibelang t?oaetso le ho fokotsa khanyetso ea lithethefatsi.

3. Litaelo tsa tlhahlobo tse hlahang (tse ka netefatsoang)

Lefu la ho ruruha ha mala (IBD) le tokiso ea thibelo ea mala ??

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Khakanyo:

Mannose e ka laola gut microbiota (ho khothaletsa libaktheria tse molemo) le ho thibela ho khomarela baktheria ea pathogenic.

Ntlafatsa ts'ebetso ea liprotheine tsa intestinal mucosal barriers ka ho fetola glycosylation.

Boemo ba hajoale: Mehlala ea liphoofolo (colitis) e bonts'a litlamorao tse itseng tsa ts'ireletso, empa lipatlisiso tsa batho li haella.

Taolo ea mafu a autoimmune ??

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Khopolo: Glycosylation e sa tloaelehang e ameha ho pathogenesis ea ramatiki ea ramatiki, lupus le mafu a mang. Tlatsetso ea mannose e ka lokisa bofokoli ba glycosylation.

Tsoelo-pele: E bonoa feela mefuteng ea lisele kapa palo e nyane haholo ea linyeoe, ntle le liteko tse matla tsa bongaka.

Thibelo ea mathata a lefu la tsoekere ??

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Maikutlo: Tsoekere e phahameng ea mali e lebisa ho nonenzymatic glycation (AGEs) e feteletseng ea liprotheine, e bakang mathata. Mannose metabolism ha e it?etlehe ka insulin ebile ha e ame tsoekere ea mali, kapa e ka fokotsa ka tlholisano sebopeho sa AGE.

Bopaki: Liteko tsa liphoofolo li bont?a hore tsoelo-pele ea lefu la tsoekere e fokotseha, 'me lipatlisiso tsa batho ha li na letho.

4. Mathata le mefokolo

Mathata a maholo t?imong

Thibelo ea UTI ha e na katleho khahlanong le likokoana-hloko tse seng tsa Escherichia coli; Lintlha tsa polokeho ea nako e telele ha li lekane (haholo-holo ts'ebetso ea renal)

Kalafo ea CDG e sebetsa feela bakeng sa li-subtypes tse itseng; Ho hlokahala tlhahlobo ea kapele le meriana ea bophelo bohle

Ho sebetsa hantle ha kalafo ea hlahala 'meleng oa motho ha ho tsejoe; Litekanyo tse phahameng li ka baka let?ollo; Kotsi ea chefo ea ho kopanya chemotherapy e hloka ho hlahlojoa

Ho se sebetse ho lekaneng ha t?ebeliso e le 'ngoe ea li-anti-infective adjuvants; Ho hlokahala ho ntlafatsa kalafo e kopaneng le lithethefatsi tse seng li ntse li le teng

Lipatlisiso tse fokolang mabapi le mekhoa ea mafapha a mang a hlahang; Ho hloka liteko tsa maemo a holimo tsa bongaka; Bongata ba bona ba sala ba le sethaleng sa mohlala oa liphoofolo

5. Tataiso ea ntlafatso ea bokamoso

Nts'etsopele ea sistimi ea phepelo e nepahetseng: Rala li-nanocarriers tse fetotsoeng ho ntlafatsa sepheo sa tumor / leqeba le t?oaetsanoang.

Ntlafatso ea kalafo e kopaneng: ho lekola litlamorao tsa mannose ka lithibela-mafu, li-immune checkpoint inhibitors, le lithethefatsi tse thibelang likokoana-hloko.

Katoloso ea Maloetse a Rare: Ho hlahloba li-subtypes tse ngata tsa CDG le mathata a polokelo ea lysosomal a ka phekoloang ka mannose.

Mokhoa oa nako e telele oa tokollo e tsitsitseng: o rarolla bothata ba ho noa meriana khafetsa (joalo ka t?ebeliso ea letsatsi le letsatsi bakeng sa thibelo ea UTI).

Leano la stratification ea baahi: meriana e nepahetseng e thehiloeng ho mofuta oa pathogen (UTI) kapa gene mutation (CDG)