Yeast beta-glucan ke polysaccharide e sebetsang e nkiloeng leboteng la sele ea tomoso. Ka 1941, Ngaka Pillemer o ile a sibolla ntho e leboteng la tomoso e matlafatsang sesole sa 'mele. Ka 1961 Riggi o ile a tsebahatsa motsoako ona o sebetsang ho yeast glycan e le beta-glucan [1]. Mehloli e tloaelehileng ea beta-glucan e boetse e kenyelletsa li-oats, li-fungus, li-seaweed, joalo-joalo, hobane 'mele ha o khone ho kopanya kapa ho pata beta-glucan ka boeona, e tlameha ho tlatsetsoa ke lefat?e le kantle.

Ntle le β-glucan le lerako la sele ea tomoso ho boetse ho na le mannose e qhibilihang ka metsi le palo e nyane ea chitin, β-glucan e ikarabella ho 30% ho isa ho 60% ea boima bo omeletseng ba lerako la sele, karolong e ka hare ea lerako la sele, ke ea polysaccharide ea sebopeho, ts'ebetso e ka sehloohong ea 'mele ke ho boloka seleng ea lerako, ho boloka seleng ea mochini. Misaki et al. e fumane hore sebopeho sa yeast β-glucan e entsoe haholo-holo ka β-1, 3-bond, 'me e na le karolo e itseng ea masala a β-1, 6-bond.

Ts'ebetso ea immunomodulatory ea tomoso beta-glucan e ipapisitse le sepheo sa eona se nepahetseng, bokhoni ba eona ba ho tlama li-receptor tse itseng holim'a lisele tsa 'mele, ha e ntse e ntlafatsa ts'ebetso ea phagocytosis ea macrophages. Ts'ebetso ena e potlakisa karabelo ea 'mele ea ho it?ireletsa mafung le ho boloka botsitso bo nepahetseng ba sesole sa' mele.

Beta-glucan e sebetsa haholo-holo ka ho tlama mefuta e meraro ea beta-glucan receptor [4]: ??(1) Dectin-1 receptor; (2) CR3; (3) Li-receptors tse ling, ho kenyeletsoa receptor ea scavenger le LacCer. Ha tomoso β-glucan e kena 'meleng oa motho' me e tlama ho receptor, e tla eketsa phosphorylation ea intracellular immune receptor tyrosine motif (ITAM) le Syk, le ho kenya t?ebetsong tsela ea PI3K / Akt, e qetellang e lebisa phagocytosis, lefu la likokoana-hloko le ho lokolloa ha cytokine, e le ho thibela ho thibela likokoana-hloko ho tsoa linaheng tse ling. 'Me joale u fumana phello ea ho it?ireletsa mafung.

Melemo ea bophelo bo botle ba letlalo ea beta-glucan e bonahala haholo maemong a latelang [6]:

1) Matla a Antioxidant: β-glucan e na le thepa ea antioxidant, e ka thibelang moloko oa superoxides le mefuta e meng ea oksijene e sebetsang (ROS) le ho fokotsa t?enyo ea khatello ea oxidative letlalong.

2) Phello ea mongobo: Ka boima ba eona bo phahameng ba molek'hule, β-glucan e na le matla a matla a ho tlama metsi, a ka khonang ho kopanya limolek'hule tsa metsi ka holim'a lisele tsa letlalo, ho thibela ho tsoa ha metsi, le ho fokotsa tahlehelo ea metsi ka epidermis (TEWL). Ho phaella moo, e etsa filimi e sireletsang holim'a letlalo, e thusa ho boloka mongobo le bonolo letlalong.

3) Ho lokisa letlalo le matla a ho folisa: Seo et al. e fumane hore mehloli e fapaneng ea beta-glucan e ka khothaletsa ho falla ha li-keratinocyte tsa motho (HaCaT) le li-fibroblasts tsa letlalo la motho (HDFa), le ho potlakisa ho koaloa ha maqeba le ho khutlisetsa epithelialization mefuteng ea litoeba [7]. Ho feta moo, thepa e khahlanong le ho ruruha le e thibelang ho halefisa ea beta-glucan e thusa ho imolla ho ruruha le bofubelu le ho kokobetsa letlalo le halefileng. Phuputso ho Journal of Therapeutic Dermatology e bont?itse hore beta-glucan ke tlatsetso e sebetsang ea phekolo ea atopic dermatitis e bonolo (eczema) [8].

4) Litlamorao tse khahlanong le botsofali: Beta-glucan e thusa ho fokotsa mat?oao a botsofali ba letlalo, joalo ka wrinkles le ho sagging. E khothalletsa tlhahiso ea collagen le likarolo tse ling tsa letlalo extracellular matrix (ECM), e eketsa botenya le elasticity ea letlalo.

Ho feta moo, beta-glucan e boetse e na le karolo ea ho laola limela tsa mala, ho fokotsa k'holeseterole, ho thibela mokhathala, bophelo bo botle ba masapo joalo-joalo.

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