Lefapheng la lipatlisiso tsa bophelo bo botle ba mala, Polydextrose ke khale e khetholloa e le fiber e tloaelehileng ea lijo tse qhibilihang ka metsing. Leha ho le joalo, liphuputso tse 'maloa tse atlehileng lilemong tsa morao tjena li bonts'itse hore molek'hule ena ea maiketsetso e entsoeng ka polymer ho tsoa ho tsoekere ehlile ke "sebapali se feto-fetohang" se nchafatsang microecology ea mala ka mochini o meraro oa "dynamic viscosity regulation - phepo e nepahetseng ea microbiota - metabolite cascade reaction". Phuputso ea morao-rao ho Nature Gastroenterology ka 2024 e bonts'a hore ho ja 10-15g ea polyglucose letsatsi le leng le le leng ho ka matlafatsa bot?epehi ba t?itiso ea mala ka 37% le ho fokotsa boemo ba ho ruruha ha IL-6 ka 29%. Se sibolotsoeng sena ha se theole temoho ea setso feela empa se boetse se etsa hore ho be le mekhoa e fapaneng ea khalemelo ho tloha indastering ea lijo ho ea ho bongaka ba bongaka.

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Youdaoplaceholder0 Khaolo ea 1 Decoding Science: The "Whole digestive tract Intelligence" ea molek'hule

Youdaoplaceholder0 1.1 Viscosity deformation: "karabelo e bohlale" ho tloha ka mpeng ho ea kholong

Ntho e ikhethang ea polydextrose e teng phetohong ea eona ea viscosity e arabelang Ph:

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Youdaoplaceholder0 Stomach (pH 1.5-3.0) : Liketane tsa molek'hule li hokahane ka li-bond tsa haedrojene ho etsa sebopeho sa marang-rang a mahlakore a mararo, sesepa sa viscosity ho fihla ho 1500 mPa·s, se fokotsa sekhahla sa ho tsoa ka mpeng ho fihla ho 45% (ha ho bapisoa le 20 feela ea fiber e tloaelehileng), haholo

Youdaoplaceholder0 Mala a manyenyane (pH 6.0-7.4) : Litlamo tsa haedrojene li robehile ka mokhoa o itseng, viscosity e fokotsehile ho 400 mPa·s, le bile acid adsorption e fokotsa ho kenngoa ha k'holeseterole ka 18% ntle le ho ama ho kenngoa ha limatlafatsi;

Youdaoplaceholder0 Colon ? (pH 7.0-7.5) : Ho belisoa ha likokoana-hloko ho qalisoa, viscosity e senyeha ho ea ka tlase ho 50 mPa·s, li-short-chain fatty acids (SCFAs) li lokolloa, 'me mahloriso a butyric acid a eketseha ka makhetlo a 3.2, a kenya ka ho toba intestinal epitheal epithel cell.

Youdaoplaceholder0 Technology Breakthrough : Theknoloji ea SmartVisc? ea DSM e ka etsa li-curve tsa viscosity bakeng sa likarolo tse fapaneng ka ho laola boemo ba polymerization (boleng ba DP), joalo ka foromo ea mofuta oa G e etselitsoeng bakuli ba reflux ea gastroesophageal, e etsang filimi e sireletsang 'mele e nang le viscosity e fihlang ho 200 m ka mpeng.

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Youdaoplaceholder0 1.2 Taolo ea Microbiota: Ho tloha ho "phepelo e pharalletseng" ho isa "phaello e reriloeng"

Li-prebiotics tsa setso hangata li susumetsa likokoana-hloko tsohle ka mokhoa o sa khetheng, ha polydextrose e bont?a bokhoni bo nepahetseng ba taolo:

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Youdaoplaceholder0 Upstream inhibition : Boemo bo phahameng ba viscosity bo theha mokoallo oa 'mele ka har'a kolone e haufi, e thibelang ho khomarela libaktheria tsa pathogenic (joaloka Escherichia coli), ho fokotsa sekhahla sa colonization ea pathogen ka 52%;

Youdaoplaceholder0 Downstream proliferation : Likaroloana tsa oligosaccharide li ne li sebelisoa ka ho khetheha ke libaktheria tse molemo tse kang Bifidobacterium le Roseella, 'me bongata ba tsona bo eketsehile ka 68% ka mor'a libeke tse 8 tsa ho kenella (ho it?etlehile ka tatellano ea metagenomic);

Youdaoplaceholder0 Metabolic synergy ? : Asiti ea butyric e hlahisoang e kenya t?ebetsong receptor ea GPR109A, e kenya t?ebetsong phapang ea lisele tsa T, 'me e ntlafatsa index ea boits'ireletso ba mala ho 0.91 (boemo ba bophelo> 0.85).

Youdaoplaceholder0 Khaolo ea 2 Sefefo sa Kopo: Boikoetliso ba ho t?ela moeli ho tloha Tafoleng ho ea Beteng ea Sepetlele

Youdaoplaceholder0 2.1 Indasteri ea Lijo: "Enjene e sa bonahaleng" e nang le mesebetsi e ntlafalitsoeng

Youdaoplaceholder0 Baking Revolution ? : Sehlopha sa Meiji sa Japane se thehile likuku tsa zero-sucrose ka ho nka monyetla oa ho boloka metsi (8.3g metsi /g) le botsitso ba mocheso (ho mamella ho 220 ° C) ea polyglucose, ho fokotsa ho fetoha ha tsoekere ea mali ka 41%.

Youdaoplaceholder0 Beverage Innovation : Nongfu Spring's Intestinal Sparkling Water, e sebelisang thepa e hlahisang khase ea polyglucose ea colonic ho kokobetsa ho soasoa ntle le ho teneha, e rekisitse libotlolo tse fetang limilione tse 8 khoeling ea eona ea pele 'marakeng;

Katleho ea Phatlalatso ea Lijo tsa Youdaoplaceholder0 : Soylent naheng ea Amerika e sebelisa foromo ea viscosity-gradient ho eketsa nako ea ho nt?a matla butle ho fihla ho lihora tse 6 le ho ntlafatsa mamello ea limathi tsa marathone ka 23%.

Youdaoplaceholder0 2.2 Phepo ea bophelo bo botle: "Thebe e thibelang mala" bakeng sa bakuli ba ICU

Thuto ea RCT ea Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University (n=204) e bont?a hore:

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Thibelo ea ts'oaetso ea Youdaoplaceholder0 : Ho bakuli ba ICU ba tlatsitsoeng ka 15g ea polydextrose letsatsi le leng le le leng, ketsahalo ea enterogenous sepsis e fokotsehile ka 44%;

Youdaoplaceholder0 Tokiso ea Mucosal ? : Maemo a Plasma ligonin (let?oao la ho kenella ha mala) a fokotsehile ka 31% mme boima ba lisele tsa goblet bo eketsehile ka 39%;

Youdaoplaceholder0 Immunomodulatory : Serum IgA concentration e eketsehile ka 28%, 'me CD4+/CD8+ T cell ratio e khutletse boemong bo tloaelehileng.

Youdaoplaceholder0 Khaolo ea 3 Phetohelo ea Theknoloji: Ho Tloha ho Moralo oa Limolek'hule ho ea ho Phepo e nepahetseng e Nolofalitsoeng ke AI

Youdaoplaceholder0 3.1 Phetoho ea sebopeho: Notlolla Customization ho latela tlhoko

Youdaoplaceholder0 Targeted viscosity : Ka ho hlahisa liketane tsa mahlakoreng a sorbitol, polyglucose (mofuta oa C) e khethehileng ea colon e ile ea hlahisoa, eo viscosity ea eona e theohileng haholo ho 10 mPa·s pH 7.0, haholo-holo bakeng sa batho ba nang le pipitlelano;

Youdaoplaceholder0 Tloaelo e ntlafetseng : Roguet, Fora, e ntlafalitse theknoloji ea Probiocoat? microcapsule e kenyelletsang li-probiotics ka har'a polyglucose matrix, ho eketsa sekhahla sa ho phela ha gastric acid ho tloha 15% ho ea ho 92%.

Youdaoplaceholder0 3.2 TLHOKOMELISO EA Maiketsetso: Ho Hlakola Khoutu ea boitshunyako bo ikhethileng

Sistimi ea "Digital Twin of the Intestine" e hahiloeng ke NutriAI, k'hamphani ea Isiraele, e kopanya linyeoe tse 200,000 tsa data ea limela tsa mala a motho le mefuta ea matla a mokelikeli, e ka bolelang esale pele karabelo ea motho ho polydextrose:

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Youdaoplaceholder0 Dose optimization ? : Motsoako oa motsoako oa 8-12g/ letsatsi + fructooligosaccharide o khothalelitsoeng bakeng sa bakuli ba IBS o fokolitse sekhahla sa ho ferekana ka mpeng ka 67%;

Youdaoplaceholder0 Scene fit : Mokhoa oa boikoetliso o matla haholo o etselitsoeng baatlelete, o eketsang sekhahla sa ho belisoa ha colonic ka 40% le ho qoba mathata a ka mpeng nakong ea boikoetliso.

Youdaoplaceholder0 \ n \ nKhaolo ea bone: Pherekano ea Liindasteri: Ntoa ea Theknoloji ea Limmaraka tsa lidolara tse libilione

Youdaoplaceholder0 4.1 Lebelo la Bokhoni: Likhamphani tsa Machaena li hatela pele ka lebelo

Youdaoplaceholder0 Baolingbao Bio : Tsetela li-yuan tse limilione tse 800 ho aha setsi se seholo sa lefats'e sa tlhahiso ea polyglucose, theknoloji ea enzymatic synthesis ho fihlela bohloeki ba 99.9%;

Youdaoplaceholder0 Hualixi Biotech : E ntlafalitsoeng nano-fibrotic polyglucose, kutlo ea taolo ea viscosity e eketsehile ka makhetlo a 4, e fumane tumello ea lijo tse Khethehileng tsa Bongaka tsa NMPA;

Youdaoplaceholder0 Transnational layout : DuPont e sebelisana 'moho le Mayo Clinic ho nt?etsa pele teko ea bongaka ea Phase III ea polydextrose thibelong ea mofet?e oa mala.

Youdaoplaceholder0 4.2 Mathata a Kelello: Lekhalo ho tloha Lab ho ea Mmarakeng oa 'Misa

Leha ho na le bopaki bo lekaneng ba saense, lipatlisiso tsa bareki li bont?a hore:

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Youdaoplaceholder0 Knowledge Blind spot : Ke 31% feela ea sechaba e utloisisang phapang e sebetsang lipakeng tsa polydextrose le likhoele tse tloaelehileng;

Youdaoplaceholder0 Maikutlo a fosahetseng a Dose : 45% ea bareki ba lumela ka phoso hore "ho feta ho molemo", e leng se ka bakang ho se phutholohe joalo ka ho ruruha;

Karabelo ea Indasteri ea Youdaoplaceholder0 : Mokhatlo oa Lijo tsa Machaena o lokolotse White Paper mabapi le T?ebeliso ea Polydextrose, o behile moeli o sireletsehileng oa 15g ka letsatsi.

Youdaoplaceholder0 Khaolo ea 5 Pono ea Bokamoso: Redefining Fibre's 'Smart Boundary'

Youdaoplaceholder0 5.1 Khatelo-pele ea Brain-Gut Axis: Borokho ba Molek'hule ho tloha Maleng ho ea ho Maikutlo

Liteko tsa morao-rao tsa liphoofolo ho California Institute of Technology li fumane:

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Youdaoplaceholder0 Phomolo ea Mat?oenyeho : Litoeba tsa sehlopha sa polyglucose intervention li ekelitse nako ea tsona ea tlhahlobo tekong ea maze ka 53%;

Youdaoplaceholder0 Mechanism tracing ? : Asiti ea Butyric e kenya t?ebetsong polelo ea BDNF ka har'a hippocampus ka mokoallo oa boko ba mali, e eketsa letsoalo la synaptic ka 29%.

Youdaoplaceholder0 5.2 Synthetic Biology: The 'Ultimate Form' ea likhoele tse hlophisitsoeng

Khamphani ea Ginkgo Bioworks e United States e fetotse mefuta ea tomoso e sebelisa theknoloji ea CRISPR-Cas9 ho hlahisa ka kotloloho "polydextrose e kentsoeng ka liphatsa tsa lefutso" ka mesebetsi e ikhethileng:

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Youdaoplaceholder0 Precise targeting : E ka khothaletsa kholo ea Achaemenia ka ho khetheha, 'me bongata ba eona bo eketsoa ka 80% mefuteng ea botenya;

Karabelo e bohlale ea Youdaoplaceholder0 : Sensor ea pH e hahelletsoeng, ho nepahala ha phetoho ea viscosity e ntlafalitsoe ho ± 5 mPa·s, e lebelletsoeng ho kena litekong tsa bongaka ka 2026.

Youdaoplaceholder0 Qetello: Ha Intelligence ea molek'hule e kopana le Gut Ecology

Leeto la mahlale la polydextrose ke nalane ea ho khutla ho tsoa "sehlahisoang sa indasteri" ho ea ho "moenjiniere oa tikoloho ea mala". E re bolella hore tsoelo-pele ea 'nete bophelong bo botle hangata e bakoa ke ho senyeha ho tebileng le ho hlophisoa bocha ha bohlokoa ba taba. Feela joalokaha mohapi oa khau ea Nobel Jennifer Doudna a itse, "Biology ea maiketsetso e re ruta hore limolek'hule li ka fuoa 'matla a ho nahana'." Phetoho ena ea thekenoloji ea bophelo bo botle ba mala, polydextrose e ka 'na ea e-ba qalo feela - ha "limolek'hule tse bohlale" tse ngata li kenella ntoeng, botho bo tla qetella bo fihletse mehato e nepahetseng khahlanong le mafu a sa foleng.