1.1 Ukusuka kulungiso lwe-membrane yeseli ukuya kwi-Cerebrovascular regulation

Ukusukela oko iCiticoline yaqala ukwenziwa yiTakeda Pharmaceutical yaseJapan ngo-1956, imbali yesicelo sayo inokuthathwa njengembali yokuphuculwa kwengqondo:

• 1980s:Isetyenziswe kuphela njenge-ejenti yokulungisa i-membrane yeseli emva kokubetha

• 2010s:Kwafunyaniswa ukuba inokunyusa i-cerebral blood perfusion (i-PET-CT ibonise ukunyuka kwe-23% kwi-lobe yesikhashana yegazi)

• Ngo-2024,I-NIH yase-United States idwelise njengeyona nto iphambili yokulawula "i-neurovascular coupling"

1.2 Ukukhula okukhulayo kwimarike yehlabathi

Ngokwedatha yoVavanyo lwe-Pharma:

Intengiso yehlabathi ifikelele kwi-4.7 yeebhiliyoni zeedola zaseMelika ngo-2024 (CAGR 12.3%)

Ukusetyenziswa kwechiza kwisampulu yezibhedlele e-China kunyuke ngama-400% kwiminyaka emithathu

Iimpawu zandisiwe ukuya kuthi ga kwi:

I-Vascular dementia (inqaku leMMSE liphuculwe ngamanqaku angama-2.1)

Ukwenzakala kwengqondo okubuhlungu (i-GOS prognostic scale inyuke ngamabakala e-1.5)

Isahluko sesibini: Ukuqhekeka kwebhokisi ye-Black ye-Mechanism of Action

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2.1 Iindlela ezintathu zeentshukumo

Inqanaba lobungqina obujoliswe kuyo: I-Phosphatidylcholine synthesis ilungisa i-neuronal membrane integrity Iklasi I: I-acetylcholine precursors yandisa ukuhanjiswa kwe-neurotransmitter Udidi lwe-IIA: Ulawulo lwe-Nitric oxide synthase luphucula ukuhlanjululwa kwe-microvascular (ukwanda kwe-diameter nge-18%)

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2.2 Ixesha lefestile yegolide yekliniki

Uphononongo luka-2024 olwenziwa siSibhedlele sokuQala esiManyaniswe neYunivesithi yaseSun Yat-sen lubonisa:

I-injection ye-intravenous ye-1000mg kwiiyure ze-6 emva kwe-cerebral infarction inokugcina indawo ye-ischemic penumbra ukuya kwi-7.2cm.3

Nangona kunjalo, akukho mahluko ubalulekileyo ngokweenkcukacha-manani xa ulawulo ludlula iiyure ezingama-72 (p=0.34).

Isahluko sesithathu: I-Vortex yeNgqungquthela

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3.1 Amathandabuzo malunga nokuVunywa

Izikhokelo ze-UK NICE: Kucatshangelwa ukuba ubungqina obukhoyo abunelanga ukuxhasa ukhuseleko lwe-inshurensi yezempilo (indleko-ngempumelelo i-￡ 45,000 / QALY)

I-Lancet Neurology **2025 Uhlalutyo lwe-Meta: Akukho mahluko ubalulekileyo ukusuka kwi-placebo kwiqela elincinane lokukhubazeka kwengqondo (p=0.21)

3.2 Umbhodamo kuNkuthazo lwezoRhwebo

Isaziso sika-2024 soLawulo lweeMveliso zonyango lweSizwe:

Amashishini alishumi elinesibini ayazibaxa imiqondiso (ukukhuthaza "unyango lwe-adjuvant" njenge "dementia yokubuyisela umva").

Uvavanyo kwiqonga elithile le-e-commerce libonisa ukuba umxholo wangempela we-32% wamalungiselelo omlomo ungaphantsi kwe-70% yemali ebhaliweyo.

Isahluko sesine: Imida yokuPhumelela kwezobuGcisa

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4.1 Inkqubo entsha yokuhanjiswa kweziyobisi

Isithintelo segazi-sengqondo esingena kwi-peptide eguqulwayo kwi-liposomes (Ilungelo lobunikazi beQela leYunivesithi yasePeking, CN202410123456.7)

Ii-microneedles eziphendulayo eziqhubekayo (Uvavanyo lwezilwanyana kwiYunivesithi yeSizwe yaseSeoul eMzantsi Korea lubonisa ukonyuka okuphindwe kathathu kwi-bioavailability)

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4.2 Ukusa kweyeza lomntu ngamnye

Uphando oludibeneyo lweBgi lufumanise ukuba:

Impembelelo yeyeza ye-CDP-cholinesterase gene polymorphic population (i-accounting ye-31% yabantu base-Asia) iye yanda nge-47%

Isahluko sesihlanu seDatha yokwenyani yeZigulana

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5.1 Amatyala abaxhamli

Ingxelo evela kwisibhedlele senqanaba eliphezulu e-Hangzhou: Emva konyango oludibeneyo, umthamo we-cerebral blood flow reserve yesigulane esineminyaka engama-62 ubudala kunye ne-cerebral infarction ibuyiselwe kwi-32% ukuya kwi-89%.

5.2 Ukuzichaza ngeqela elingekho mthethweni

"Ukuyithatha isiqingatha sonyaka ngokuqhubekayo, iindleko zenyanga ze-yuan ezingama-300 zazisa kuphela isisu esibuhlungu" - irekhodi lodliwano-ndlebe likaNksz Li, isigulana saseBeijing.