Iswekile sisihloko esiqhelekileyo kunye nesinzima kubomi bethu bemihla ngemihla. Ukusuka kwi-sucrose eqhelekileyo, i-fructose ukuya kwi-D-mannose encinci eyaziwayo, namhlanje, siza kuthetha malunga neqhosha eliphantsi kodwa elinamandla kakhulu - i-D-mannose.

I-D-mannose inokuvakala njengegama elingaqhelekanga, kodwa ngokwenene yi-hexose yendalo efumaneka ngokubanzi kwindalo. Ngokungafaniyo ne-sucrose kunye ne-fructose, i-D-mannose iza emehlweni oluntu kunye nobumnandi bayo obukhethekileyo kunye neenzuzo ezininzi zempilo. Ubumnandi bayo bumalunga ne-60% ye-sucrose, ishukela ephantsi kweekhalori ezisebenzayo, ukuphishekela ukutya okunempilo kubantu banamhlanje, ngokungathandabuzekiyo lukhetho oluhle.

I-D-mannose ayithandeki nje kuphela, kodwa nexabiso layo lesicelo liyamangalisa. Kwintsimi yokutya, inokusetyenziswa njenge-sweetener ephantsi kweekhalori zokuvelisa ukutya okunempilo okwahlukeneyo; Ngelo xesha, ngenxa ye-antioxidant, i-anti-inflammatory kunye nezinye iipropati, njenge-moisturizer kunye ne-anti-aging izithako zisetyenziswa kakhulu kwii-cosmetics. Kwinkalo yezonyango, ibonise amandla amangalisayo, kwaye izifundo zibonise ukuba i-D-mannose inokunciphisa isifo se-inflammation, iphathe i-rheumatoid arthritis, ithintele ukuvuvukala kwe-asthmatic airway, kwaye ibonise iziphumo ezilungileyo kunyango lomhlaza kunye nokuphazamiseka kwe-congenital glycosylation.

Kwiminyaka yakutshanje, ngophuhliso olukhawulezayo lwe-biotechnology, indlela yebhayoloji ngokuthe ngcembe ibe yeyona ndlela iphambili yemveliso ye-D-mannose. Le ndlela isebenzisa i-enzymes ye-biological catalyze reaction to convert other sugars (ezifana ne-D-fructose) zibe yi-D-mannose, enenzuzo yokusebenza okuphezulu, ukukhuselwa kwendalo kunye neendleko eziphantsi.

Phakathi kwee-enzymes ezininzi zebhayoloji, i-D-mannose isomerase iyathandwa ngenxa yomthamo wayo ophezulu we-catalytic. Nangona kunjalo, uninzi lwezifundo zokuqala zasebenzisa i-Escherichia coli njengeeseli ze-chassis kwimveliso, eyaphucula ukusebenza kakuhle kwemveliso kodwa yazisa nemingcipheko yokhuseleko. Ngapha koko, i-E. coli ayilona uhlobo olukhuselekileyo lokutya, kwaye imichiza eyivelisayo ibeka umngcipheko wokungcoliseka kwe-endotoxin. Ukuze kusonjululwe le ngxaki, izazinzulu zaqalisa ukukhangela ezinye iintlobo ezikhuselekileyo. Ekugqibeleni, bakhetha i-Bacillus subtilis njengeseli entsha ye-chassis. I-Bacillus subtilis iye yatsala ingqalelo enkulu ngenxa yeempawu zayo zokulwa ne-antibacterial non-toxic, engenabungozi, esebenzayo, akulula ukuhlala kwaye akukho lula ukuvelisa ukuchasana kweziyobisi. Okona kubaluleke kakhulu, iye Yaqondwa ngokubanzi njengohlobo lwe-"Generally Recognised as Safe" (GRAS) oluhlangabezana neemfuno zococeko lokutya.