Abantu abangaphezu kwezigidi ezingama-500 emhlabeni wonke banesifo seswekile, i-90% yabo inesifo seswekile se-2. Izigulane kufuneka zilawule ukuguquguquka kweswekile yegazi ebomini, kunye neeshukela zendabuko (ezifana ne-sucrose kunye ne-fructose) zidweliswe njengezichaso zokutya kuba zibangela ngokuthe ngqo ukunyuka kweshukela egazini. Nangona kunjalo, imfuno yempilo yomntu yencasa eswiti kunzima ukuyiphelisa, kwaye kwavela iimveliso ezithatha indawo yeswekile. I-Sucralose, njengesizukulwana sesine se-sweetener, itsale ingqalelo ebanzi kwiipropathi zayo "zero zero kunye nobumnandi obuphezulu" 13.

2. Iimpawu ze-Metabolic kunye nokhuseleko lwe-sucralose
1. Inzuzo ye-Metabolic
Isakhiwo semolekyuli ye-sucralose iguqulwa yi-chlorination, engachithwanga yi-enzymes yokugaya ukutya kwabantu. Ngokumalunga ne-85% ye-sucralose ikhutshwe ngokuthe ngqo emathunjini emva kokutya, kwaye i-15% eseleyo ifakwe kwi-metabolized kwi-non-toxic compounds ngesibindi kwaye ikhutshwe kumchamo. Izifundo zeklinikhi ziqinisekisile ukuba i-glycemic index yayo yi-0, kwaye akukho kulungelelaniswa ngokuthe ngqo kunye ne-insulin secretion 12. Ngokomzekelo, ulingo olulawulwa yi-International Diabetes Federation (IDF) lwango-2024 lubonisa ukuba akukho tshintsho lubalulekileyo kwi-glucose yegazi ngokukhawuleza kunye namanqanaba e-A1C kwizigulana ezingama-50 ezinesifo seswekile esiye satya iziselo ze-sucralose iintsuku ezingama-30 ezilandelelanayo.

2. Uhlalutyo lwe-dialectical yeengxabano zokhuseleko
Nangona uphando oluqhelekileyo luxhasa ukhuseleko lwalo, kusekho iinkxalabo malunga nemingcipheko enokubakho:

Impembelelo ye-gut microbiota : Uphononongo lwango-2024 olupapashwe kwiNature Microbiology lubonise ukuba ukutya okungaphezulu kwe-15g ye-sucralose yonke imihla kuthintele ukusebenza kweeprobiotics ezifana ne-bifidobacterium, okubangele ukuhla kwe-20% -30% kwi-gut microbiota diversity 37;
Ukusebenzisana kweziyobisi : Xa idibene ne-anticoagulant warfarin, i-sucralose inokunciphisa i-bioavailability yeziyobisi nge-12% -15%. I-27 kufuneka ithathwe kwiiyure ezi-2 ngaphandle;
...
ukusetyenzwa kweengozi eziphuma kwimveliso : ukubhaka ubushushu obuphezulu (> 150℃) kunokuvelisa amanani omkhondo we-chloropropanol (Okwesithathu, isicwangciso senzululwazi sokutshintshwa kweswekile
1. Ulawulo lwedosi lulungelelaniswe kwindawo
I-World Health Organization (WHO) icebisa ukuba abantu abanesifo seswekile bangadli ngaphezu kwe-9mg / kg ye-sucralose yonke imihla (malunga ne-540mg kumntu omdala we-60kg). Iimeko kufuneka zahlulwe kwizicelo ezibonakalayo:

Isiselo esinxilisayo se-seasoning : 300ml isiselo sokutya siqulethe malunga ne-30mg ye-sucralose, eyi-5.5% kuphela yomlinganiselo okhuselekileyo we-16;
iimpahla ezibhakiweyo : Khetha i-pastry eyenziwe ngenkqubo yobushushu obuphantsi (2. Ulawulo lokutya oludibeneyo
Ukutshintsha iswekile akuthathi ndawo yolawulo lweswekile ngokubanzi:

isondlo esinokulinganisela : Dibanisa iinkozo ezipheleleyo (i-GI engaphantsi kwe-55) kunye ne-fiber yokutya (i-25-30g imihla ngemihla) ukulibazisa ukufunxa i-glucose 46;
Ukujongwa kweswekile yegazi : I-glucose yegazi ifunyenwe kwiiyure ze-2 emva kokutya ukutya okuthatha indawo yeswekile, kwaye i-archive yempendulo yomntu ngamnye 58 yasekwa.
4. Imilinganiselo yoshishino kunye nemfundo yabathengi
1. Ukumiswa komgangatho wokuleyibhile kokutya
Uhlaziyo oluhlaziyiweyo lweMithetho ePhakamileyo yaseTshayina yokuFakwa kokuFakwa kokuFakwa kokuTyelwa kwangaphambili ngo-2025 ifuna ukuba ukutya okune-sucralose kufuneka kumakishwe ngesilumkiso "Izigulana ezinesifo seswekile kufuneka zilawule i-carbohydrate ethathwayo" kwaye ibonise umxholo wokongeza (mg/100g) 24.

2. Impendulo yesiphithiphithi semarike
Ngo-2024, i-General Administration of Market Supervision yafumanisa ukuba i-18.7% "ye-sugar-free" igcina i-glucose eyongeziweyo, ibeka njenge-sucralose. Abathengi kufuneka bakhethe iimveliso ezinesatifikethi se-SC kunye neengxelo ezipheleleyo zovavanyo 78.

5. Isikhokelo soPhuhliso lwexesha elizayo
1. Ukuveliswa kweteknoloji
Ngo-2025, iJinhe Industrial yasungula inkqubo "ye-chlorination ekhokelwayo" yokunciphisa inani eliseleyo le-sucralose chloropropanol ukuya kwi-0.01ppm, kunye nokwandisa ixesha lokukhululwa kwamathumbu ngokusebenzisa iteknoloji ye-microcapsule ukunciphisa ukuphazamiseka kwebhaktheriya 18.

2. Uphando lwezonyango olusekelwe kubungqina
I-International Diabetes Association isungule inkqubo yeminyaka emi-5 "yokutshintsha iswekile kunye ne-metabolic syndrome" yokuvavanya ukhuseleko lwexesha elide lwe-sucralose kubantu abayi-100,000 abanesifo seswekile.