Ngo-1832, isazi samachiza saseFransi uMichel Eug è ne Chevreul waqala wafumanisa i-creatine kwi-skeletal muscle, eyathi kamva yabizwa ngokuba yi "Creatine" emva kwegama lesiGrike elithi "Kreas" (inyama). I-Creatine igcinwa ikakhulu kwizicubu zezihlunu, ezinokunciphisa ukudinwa kwemisipha kunye nokuxinezeleka, ukuphucula ukunyameka kwezihlunu, ukwenza izihlunu zomelele, ukukhawulezisa ukuhlanganiswa kweeprotheyini emzimbeni womntu, ukunciphisa i-cholesterol, i-lipids yegazi, kunye neswekile yegazi, ukulibazisa ukuguga, kunye nokudlala indima xa imfuno yamandla iphezulu. Ngokuncedisa i-creatine, umzimba womntu unokunyusa i-creatine reserves, uphucule amanqanaba e-phosphocreatine kwizihlunu, kwaye uphucule ixesha elifutshane, ukusebenza komthambo ophezulu. Uphando lubonise ukuba izongezelelo ze-creatine azikwazi nje ukulibazisa ukudinwa kwemisipha, ukuphucula amandla okudubula kunye nokunyamezela kweembaleki, kodwa zikwanceda ukukhuthaza ukukhula kwemisipha kunye nokuchacha, oko kukwenza isongezo sesondlo esisebenzayo kubathandi bokuqina kunye nabadlali.