I-HMB yi-metabolite ephakathi ye-amino acid leucine ebalulekileyo yomntu, kwaye umzimba womntu unokuvelisa inani elincinci le-HMB ngokwayo. Ukutya okuqhelekileyo, umzimba womntu uvelisa malunga ne-300 ukuya kwi-400 mg ngosuku, apho i-90% ivela kwi-catabolism ye-leucine. I-HMB ingasetyenziselwa ukukhuthaza ukukhula kwemisipha, ukuphucula ukukhuseleka, ukunciphisa i-cholesterol kunye namanqanaba aphantsi e-lipoprotein ephantsi emzimbeni ukunciphisa ukuvela kwesifo senhliziyo kunye nesifo senhliziyo, kodwa nokuphucula amandla okulungisa i-nitrogen yomzimba, ukugcina amanqanaba eprotheni emzimbeni, kunye nokuthintela ukubola kwemisipha kwizigulane ezilele ebhedini okanye ezikhubazekileyo. Kwiminyaka yakutshanje, kuba inokunciphisa umonakalo wezicubu ze-muscle emva kokuzivocavoca, ukulungisa imicu ye-muscle, ukwandisa amandla emisipha kunye nokutshisa amanqatha omzimba, ibe yinto eyinkwenkwezi kwimveliso yezondlo zezemidlalo. Ukongeza, i-HMB ibonakaliswe ngokweklinikhi ukukhawulezisa ukuphiliswa kwenxeba kunye nokuthintela ukudumba. Uphononongo lubonise ukuba i-Ca HMB inokukhawulezisa ukuhlanganiswa kweeprotheyini kunye nokunciphisa ukusetyenziswa kweeprotheyini. I-Ca HMB idityaniswe ne-glutamine kunye ne-arginine inokuphucula ibhalansi ye-nitrogen engalunganga yezigulane kwaye idlale indima efanelekileyo ekubuyiseleni kwintlungu kunye nokuhlinzwa.

Kwi-2011, uMphathiswa wezeMpilo wase-China wangaphambili wachaza imvume ye-β-hydroxy-β-methylbutyrate calcium (Ca HMB) njengento entsha yokutya, ukusetyenziswa kokutya okunomsoco wezemidlalo, ukutya okukhethekileyo kokusetyenziswa kwezonyango, isixa esicetyiswayo ngu-≤3 grams / ngosuku. Kwi-2017, iKomishoni yeSizwe yezeMpilo kunye noCwangciso lweNtsapho yazisa ukwandiswa komda wesicelo se-Ca HMB ukusuka kwizicelo ezimbini zokuqala ukuya kwisithoba, kwaye yagunyazisa amaziko obuchwepheshe bovavanyo lomngcipheko ukwenza uvavanyo lokhuseleko. Ukusetyenziswa kwe-Ca HMB kwandiswe ukubandakanya iziselo, ubisi kunye neemveliso zobisi, iimveliso ze-cocoa, i-chocolate kunye neemveliso zetshokolethi, i-candy, izinto ezibhakiweyo, kunye nokutya okukhethekileyo kokutya, kwaye isixa esicetyiswayo sasise-≤3 g / ngosuku, engazange idlule i-dosage yamavolontiya olingo lwabantu. I-Ca HMB yaqatshelwa njenge-GRAS yi-US Food and Drug Administration ngo-1995 kwaye isetyenziselwa ukutya kwezonyango kunye nokutya okukhethekileyo. Kwiminyaka engama-20 edlulileyo, i-Ca HMB isetyenziswe ngokubanzi kwiimveliso zobisi, iimveliso zetshokolethi, iziselo, imivalo yamandla kunye nokunye ukutya kwimarike yase-US. I-Ca HMB yinto yokutya ekrwada evunyelwe yimimiselo yaseJapan, enokongezwa kwiinkalo ezininzi ezifana nokutya okuqhelekileyo, ukutya okunomsoco wezemidlalo, ukutya okunciphisa umzimba, ukutya okunobuhle, njl. Kubavelisi kunye neekhemesti, i-Ca HMB ngoku yenye yezona zithako zezempilo ezidumileyo kwimarike yaseJapan.