1, Indlela engundoqo

Ujoliso lwebhaktiriya ye-metabolite glyoxylate

Iibhaktheriya ezixhathisa iziyobisi ziphakamisa ukubonakaliswa kwe-glyoxylate kwiindawo ezinqongopheleyo zezondlo, ezilungisa kwakhona iimpawu ze-epigenetic, zenza buthathaka iimpendulo ze-immune, kwaye zincede iibhaktheriya ziphile phantsi koxinzelelo lwe-antibiotics ngokuthintela umsebenzi we-DNA demethylase (TET2) kwiiseli zomkhosi.

I-Vitamin C ivuselela umsebenzi we-enzyme ye-TET2

I-Vitamin C, njenge-activator yendalo ye-TET2, inokuchasana ne-inhibitory effect ye-glyoxylate kwi-immune immunity, ibuyisele umsebenzi we-DNA demethylation, kwaye iqalise kwakhona inkqubo yokukhusela umzimba.

Ukuphazamisa isicwangciso "sokufa kobuxoki" kweebhaktheriya

I-Acetaldehyde ngaxeshanye ivula indlela yokuzikhusela yebhaktiriya, yenze abaphikisi ukubaleka ukubulala amayeza okubulala iintsholongwane. I-Vitamin C edityaniswe ne-antibiotics inokophula olu tshintsho lwe-metabolic kwaye inciphise kakhulu umthwalo webhaktheriya.

2. Ubungqina bovavanyo

Ukuqinisekiswa kwemodeli yezilwanyana: Kwimodeli yokusuleleka kwegundane, ukudibanisa kwe-vitamin C kunye ne-antibiotics yandisa izinga lokusinda nge-60%, yanciphisa umthwalo webhaktheriya kwizicubu nge-80%, kunye nokunciphisa amanqanaba ezinto ezivuthayo ngama-50%.

Impembelelo ye-Synergistic: I-Vitamin C iphucula indlela yokubonisa i-interferon (IFN), iqinisa amandla e-immune cell ukucima iibhaktheriya ezinganyangekiyo ngamachiza, kwaye inqanda i-STAT1 dephosphorylation, ukwandisa ixesha lokuphendula kwe-immune anti-tumor.

3, Uncedo lwezonyango olunokwenzeka

Ukoyisa ingxaki yokunganyangeki ngamachiza: Esi sicwangciso-qhinga sibonelela ngonyango olutsha olungaxhomekekanga kwisibulali-zintsholongwane kunyango olutsha lwentsholongwane ekwaziyo ukumelana neyeza njenge-Salmonella kunye ne-Mycobacterium tuberculosis, ngakumbi kwizigulana ezinosulelo oluphinda-phindayo okanye amayeza okubulala iintsholongwane angasebenziyo.

Isicwangciso sonyango esilula: I-Vitamin C, njengesondlo esikhuselekileyo kunye nexabiso eliphantsi, inokusetyenziswa ngokudibanisa ne-antibiotics ekhoyo ukuze kuncitshiswe umthamo wamachiza kunye nokunciphisa imiphumo emibi.

Ixabiso lokukhusela lokukhusela: Ukutya okwaneleyo kwee-micronutrients (ezifana ne-vitamin C) kunokunciphisa ngokungathanga ngqo umngcipheko wokudluliselwa kwemfuza yokumelana neyeza ngokugcina ibhalansi ye-gut microbiota.

4. Izikhokelo zophando lwexesha elizayo

Phonononga iziphumo ze-synergistic kunye nedosi eyiyeyona indibaniselwano yevithamin C kunye nezinye izibulala-ntsholongwane ezifana ne-beta lactams kunye neequinolones.

Vavanya ifuthe lexesha elide le-vitamin C eyongezelelweyo kwi-evolution ye-bacterium enganyangekiyo ngamachiza.

Ukuphuhlisa inoveli amachiza eantibacterial ejolise kwi-glyoxylic acid-TET2 axis