I-Lycopene (LYC), i-carotenoid, i-pigment e-fat-soluble, efumaneka kakhulu kwiitumato, ivatala, i-grapefruit kunye nezinye iziqhamo, yeyona pigment iphambili kwiitumato ezivuthiweyo. I-Lycopene ineenzuzo ezahlukeneyo zempilo, kubandakanywa ukukrazula i-radicals yamahhala, ukunciphisa ukuvuvukala, ukulawula i-glucose kunye ne-lipid metabolism, kunye nemiphumo ye-neuroprotective.

Kungekudala, abaphandi abavela kwiYunivesithi yezoNyango yaseShanxi bapapashe iphepha kwiphephancwadi i-Redox Biology enesihloko esithi "I-Lycopene inciphisa ukusilela kwengqondo okunxulumene neminyaka ngokusebenzisa i-activating-brain-brain. Iphepha lophando lwe-fibroblast factor factor-21 signaling ".

Uphononongo lubonise ukuba ukuncedisa nge-lycopene kwiinyanga ze-3 kunokulibazisa ukuguga kwengqondo kwiimpuku kunye nokunciphisa umonakalo onxulumene neminyaka yobudala, kwaye i-lycopene iphucula ukuchithwa kwe-neuronal, ukungasebenzi kwe-mitochondrial, umonakalo we-synaptic, kunye nokukhuthaza i-synaptic vesicle fusion kwiigundane eziguga.

Ukongeza, i-lycopene isebenze i-axis yesibindi-ingqondo ye-FGF21 ebonisa iimpuku ezigugayo, ngaloo ndlela ikhuthaza ukukhululwa kwee-neurotransmitters ngokunyusa amanqanaba e-ATP ye-mitochondrial kunye nokuphucula i-synaptic vesicular fusion. Oku kuphakamisa ukuba i-FGF21 inokuba yinto ekujoliswe kuyo yonyango kwizicwangciso zongenelelo lwesondlo ukulibazisa ukuguga kwengqondo kunye nokuphucula ukuphazamiseka kwengqondo okunxulumene neminyaka.

Ekugugeni, ukuguga kwengqondo, ukungasebenzi kwe-mitochondrial yenye yezona zinto zibalulekileyo, abaphandi bafumanisa ukuba ukuxhaswa kwe-lycopene kunokuphucula umonakalo we-mitochondrial morphological, kunye nokuguqula inqanaba le-mitochondrial ye-electron yokuthutha i-complex ebangelwa ukuguga, ukukhuthaza ukuveliswa kwe-ATP, ebonisa ukuba umsebenzi we-lycopene unempembelelo yokukhusela kwi-mito.

Okokugqibela, abaphandi baye baqhuba iimvavanyo ze-vitro kwaye bafumanisa ukuba i-lycopene yonyusa amandla eeseli zesibindi ukuxhasa i-neurons, kubandakanya nokuphucula ukuguga kweeseli, ukuphucula ukusebenza kwe-mitochondrial, kunye nokwandisa ubude be-neuron axon.

Kuthatyathwe kunye, iziphumo zibonisa ukuba ukuxhaswa kwe-lycopene kunokulibazisa ukuguga kwengqondo kunye nokuthintela ukuphazamiseka kwengqondo okunxulumene neminyaka kwiigundane, ngokuyinxenye ngenxa yokuba i-lycopene ivuselela i-hepato-brain axis FGF21 ukubonakaliswa, iphakamisa ukuba i-FGF21 inokuba yinto ekujoliswe kuyo yonyango kungenelelo lwesondlo ukuze kuphuculwe izifo ezibangelwa yi-neurogenerate ye-cognitive.