Indlela ye-molecular kunye nokuphumelela kwesicelo seklinikhi ye-HMB Ca ekunciphiseni ukulimala kwemisipha
I-1.Ukulawulwa kwe-Bidirectional ye-protein metabolism
I-HMB ifezekisa ulungelelwaniso oluguquguqukayo lokulungiswa kokwenzakala kwezihlunu ngokusebenzisa iindlela ezininzi zokusebenzisana:
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Ukusebenza komqondiso we-mTOR: ukunyuka kwenqanaba le-ribosome S6 kinase phosphorylation nge-38%, i-myosin enzima yetsheyini kunye nezinye iiprotheyini eziphambili
Impembelelo yokuthintela ubiquitination : iyancipha intetho ye-E3 ubiquitin ligase MuRF1 nge-41%, kwaye ivalwe inkqubo yokumakisha imolekyuli yokuphuka kwemisipha.
i-autophagy homeostasis : Yandisa umlinganiselo we-LC3-II/LC3-I ukuya kwi-1: 1.5 ukuthintela ukuthotywa kwefiber ye-muscle okubangelwa kukuzikhukhumeza okugqithisileyo.
Okwesibini, iteknoloji yokukhusela inwebu yeseli entsha
I-HMB iphucula uzinzo lweseli ngongenelelo lwenqanaba lemolekyuli:
Ukomelezwa kwesakhiwo senwebu: ukonyusa umxholo we-phosphatidylinositol nge-27%, phucula ukuchasana noxinzelelo lomatshini lwenwebu yemisipha.
Ukulawulwa kwe-calcium ion: inqanda ukuvuleka okungaqhelekanga kwe-mitochondrial permeability transition pore kunye nokunciphisa umngcipheko wokugcwala kwe-calcium ngama-63%
Ukukhuselwa koxinzelelo lwe-oxidative: indlela ye-Nrf2 esebenzayo, umsebenzi we-superoxide dismutase (SOD) wonyuke nge-41%
Iii. Idatha ye-Empirical yamayeza ezemidlalo
1.Ukhuseleko oluphezulu lwezemidlalo
Abadlali bebhola abafakela i-3 g / ngosuku i-HMB yanciphisa i-peak creatine kinase (CK) nge-44% kunye nokunciphisa ixesha lobunzima be-muscle nge-51%
Emva kweeyure ze-72 zokuzivocavoca kwe-centrifugal, iziganeko ze-Z-line rheology ye-muscle fibers zancitshiswa ngu-62%, kwaye ukunyaniseka kwesakhiwo se-mitochondria kwaphuculwa nge-83%
2.Ukunyamezela ukusebenza kakuhle
Kwiimbaleki zemidyarho, amanqanaba e-lactate yegazi ehle nge-19% kunye nezihlunu ze-glycogen reserves zonyuke ngama-27% 68.
Umjikelo wokongeza weeveki ezi-6 unyuse i-VO2max nge-4.2% kunye nokwandisa ukunyamezela komthambo nge-13%
4.Inkqubela phambili yenguqu kwezonyango
5.Ukuthintela kunye nokunyangwa kwe-muscular atrophy gravis
Kwizigulana ze-ICU ezongezwa nge-HMB iintsuku ezingama-28, ubukhulu bezihlunu ze-quadriceps zagcinwa nge-1.3mm ngaphezulu, kwaye izinga lempumelelo ye-ventilator ngaphandle kwe-line yonyuka ngama-31%
Kwizigulane ezitshisa kakhulu, izinga lokuqhekeka kweprotheyini lalingaphantsi kwe-47% kwaye ixesha lokuphulukisa isilonda lalifutshane ngeentsuku ezi-5.
2.Ukungenelela kwi-senile sarcopenia
Emva kweeveki ze-12 zokungenelela, isantya sokuhamba kwabantu abadala abaneminyaka engaphezu kwe-70 senyuke nge-0.15m / s, kwaye umngcipheko wokuwa wehla nge-38%
I-MRI ibonise ukuncipha kwe-21% kwi-intramuscular fat infiltration kunye nokwanda kwe-14% kwindawo ye-fiber ye-muscle ye-II.
5.I-Cutting-edge yeteknoloji entsha
Inkqubo yokuhanjiswa kweNano
Itekhnoloji ye-Liposome encapsulation yandise ukugxilwa kwe-muscle ekujoliswe kuyo ngamaxesha e-3.7, kwaye izinga lokuguquguquka kwegazi lalingaphantsi kwe-7%
I-smart transdermal patch ifezekisa ukulawulwa kwempendulo ye-EMG kwaye inciphisa ukulibaziseka kokukhululwa ukuya kwimizuzwana ye-15.
Ukuphumelela kwibhayoloji yokwenziwa
Imveliso yobunjineli yoxinzelelo yonyuswe ukuya kwi-8.7g/L kwaye iindleko zokuvelisa zancitshiswa ngama-62%
Itekhnoloji yokuhlela ye-CRISPR ikhawulezisa ukulungiswa kwemisipha nge-41%, ingena kwizilingo zangaphambili.
6.Iinkcukacha zokhuseleko
Ityhefu ebukhali: i-LD50 yomlomo> 5000mg/kg kwiimpuku, eneneni ayinayo ityhefu.
Ukusetyenziswa kwexesha elide : Akukho tyhefu ye-hepatorenal yabonwa emva kweenyanga ze-12 zokungenelela, kwaye iziganeko zokuphazamiseka kwesisu kwaba
Umgangatho wedosi: inani lokuzilolonga liyacetyiswa ukuba lithathe i-3 g / ngosuku kwiidosi ezahluliweyo, idosi yonyango yongezwa ngamanyathelo.
Vii. Ikamva elizayo
Umgaqo we-epigenetic: Ukuphonononga iziphumo ze-HMB kwi-DNA methylation iipateni zeeseli ze-muscle stem
Indlela yokunxibelelana koluntu lwebhaktiriya: Uhlalutyo lwendima yolawulo ye-HMB metabolites kumathumbu e-intestinal firmicutes/Bacteroides ratio.