Citicolineisetyenziswe ngokubanzi kwiinkqubo zeklinikhi, ngokukodwa kunyango lwe-neurological sequelae ebangelwa ukulimala kwe-craniocerebral okanye ingozi ye-cerebrovascular, kwaye ifumene ukusetyenziswa okutsha kwindlela yokusebenza kwekliniki. Unyango lwayo kwi-cerebral hemorrhage, isifo sika-Parkinson, i-glaucoma, i-diabetes peripheral neuropathy kunye ne-tinnitus kunye nezinye izifo ziye zatsala ingqalelo ekhulayo. Ngoko yintoni i-citicoline, yintoni imiphumo ye-pharmacological, izibonakaliso zayo (unyango oluthile lweziphi izifo), ukusebenza kunye nokhuseleko?

I-Citicoline yi-nucleotide enye eyenziwe yi-ribose, i-cytosine, i-pyrophosphate kunye ne-choline. Yi-nucleotide engapheliyo yomzimba womntu. Ibandakanyeka kwiindlela ezininzi ezibalulekileyo zemetabolism emzimbeni. Yinto engaphambili yendalo ye-phospholipid synthesis ye-neuron cell membrane structure kunye ne-precursor ye-biosynthesis ye-neurotransmitter acetylcholine.

I-Citicoline yi-agent ye-neuroprotective enokukhusela i-neurons esengozini, ngaloo ndlela inciphisa okanye ithintele ukuqhubela phambili kwesifo. Okwangoku, ii-agent ze-neuroprotective ezidla ngokusetyenziswa kwiklinikhi zibandakanya i-calcium channel blockers, i-glutamate antagonists, i-scavengers ye-radical yamahhala, kunye ne-cell membrane stabilizers, phakathi kwayo i-citicoline yeye-cell membrane stabilizers.

Citicolineineempembelelo ezininzi ezijoliswe kuzo kwi-pharmacological, kwaye ezi ndlela zesenzo zenza ukuba zibe namandla amakhulu ekukhuseleni i-neuroprotection kunye nokulungiswa kwemithambo-luvo. Inempembelelo ye-neuroprotection yokuthintela ukwenzeka kokulimala kwe-neuronal kunye nefuthe lokulungiswa kwe-nerve emva kokuvela kokulimala kwe-neuronal, eyandisa ifestile yexesha lonyango ye-citicoline.

Ngokusekelwe kwiipropati zayo ze-pharmacological, i-citicoline isetyenziswa ngokubanzi kunyango lwe-stroke, ukuphazamiseka kwengqondo, ukulimala kwengqondo ebuhlungu, isifo sika-Parkinson, i-glaucoma, i-diabetic peripheral neuropathy, i-tinnitus kunye nezinye izifo, kunye nokusebenza kwayo kunye nokhuseleko luye lwaqinisekiswa kwizifundo ezininzi zeklinikhi, kunye nobungqina obaneleyo obusekelwe kubungqina bezonyango. I-Stroke: i-stroke luhlobo lwe-cerebral vascular blockage okanye ukuphuka, okubangelwa ukulimala kwengqondo yeklasi yezifo, kuquka i-ischemic kunye ne-hemorrhagic stroke, apho i-ischemic stroke yeyona ndlela iphambili ye-stroke, i-accounting ye-75% ukuya kwi-90% yazo zonke izibetho. Umngcipheko wobomi be-stroke kuluntu lwethu ngu-35% -40.9%, ubeka kuqala kwihlabathi, kungekhona nje kuphela, i-stroke nayo yimbangela yokuqala yokufa kunye nokukhubazeka kubahlali bethu.

Ubungqina bophando lweklinikhi:

1. Ngo-2002, i-American Journal Stroke yapapasha i-meta-analysis yolingo lwezonyango kwizigulane ezine-acute ischemic stroke, ebonisa ukuba i-oral citicoline yandisa amathuba okuba izigulane zibuyele emva kweenyanga ezi-3 [1].

2. Kwi-2009, uphando lophando lweziyobisi lwenziwa eMzantsi Korea kwizigulane ze-4191 ezine-acute ischemic stroke, kwaye iziphumo zibonise ukuba i-citicoline iphucule inqaku le-NIHSS kunye namanqaku e-BI yezigulane ezinezibonelelo kunyango lwangaphambili kunye nexesha elide, kunye neenzuzo zesicelo sexesha elide zazinkulu, kwaye umphumo wonyango wawulungelelaniswe kakuhle kunye nedosi. Uphuculo lwalubaluleke kakhulu kwiqela le-dose ephezulu (≧2000mg / ngosuku), kwaye ukusetyenziswa kwexesha elide kwakukhuselekile kwaye kunyamezeleke [2].

3. Iziphumo ze-multicenter, i-randomized, i-double-blind-blind, i-placebo-controlled controlled pilot study kwi-cerebral hemorrhage ibonisa ukuba i-citicoline iyisilwanyana esikhuselekileyo sonyango lwe-cerebral hemorrhage kunye nesiphumo esihle sonyango [3].

4. I-label evulekile, i-randomized, i-parallel study ivavanye umphumo we-citicoline kwi-post-stroke yokukhubazeka kwengqondo, kwaye iziphumo zibonise ukuba ukusetyenziswa kwexesha elide le-citicoline kuphucula kakhulu ukukhubazeka kwengqondo emva kokuphazamiseka [4].