Ukwaluphala yinkqubo entsonkothileyo, enezigaba ezininzi, ngokuthe ngcembe eyenzeka kubo bonke ubomi. Ngokuhamba kwexesha, amalungu kunye nezihlunu zomzimba womntu ziya kuguga ngokuthe ngcembe, kwaye ezinye izifo ziya kwenzeka ngokukhula kweminyaka, kubandakanya umhlaza, isifo seswekile, izifo zentliziyo kunye nokunye.

Uphando oluninzi lubonise ukuba i-phytochemicals, kuquka i-polyphenols, i-flavonoids, i-terpenoids, njl., inokwandisa ubomi obunempilo ngokusebenzisa i-anti-oxidation, i-activation ye-autophagy ye-mitochondrial kunye nezinye iindlela, kwaye zinempahla yokulwa nokuguga.

Ngaphambili, abaphandi bafumanisa ukuba isicatshulwa se-sage sinokulibazisa ukuguga kwizilingo ze-vitro, kwaye kwimouse kunye nemodeli ye-vitro yabantu, isicatshulwa se-sage sanciphisa kakhulu inani leeseli ze-beta-galactose ze-sidase ezinxulumene nobudala, ezibonisa iimpawu zokulwa nokuguga.

Kutshanje, Abaphandi kwiYunivesithi yasePadova eItali bapapashe iphepha kwijenali yeNdalo yokuguga enesihloko esithi "Ukujolisa kwi-senescence ebangelwa bubudala okanye ichemotherapy ngepolyphenol-rich. Isicatshulwa sendalo siphucula ixesha elide kunye nempilo kwiimpuku."

Uphononongo lubonise ukuba ukuthathwa kwemihla ngemihla ye-sage extract kunokwandisa ixesha lokuphila kunye nokuphila okunempilo kweegundane, ukuvimbela ukuvuvukala okubangelwa ubudala, i-fibrosis kunye namanqaku okuguga kwiintlobo ezahlukeneyo zezicubu, kunye nokuphucula i-phenotypes yokuguga.

Kolu phononongo, abaphandi bahlalutya amandla okulwa nokuguga kwe-sage extract (HK) kwi-vivo ngokusebenzisa iimodeli zemouse, ngokongeza iidosi eziphantsi ze-HK kumanzi okusela imihla ngemihla, kunye nokuhlalutya ukuqokelelwa kweeseli zesenescent kwiimodeli zemouse, kunye neeparitha ezininzi ezinxulumene nobudala, kubandakanya ixesha elide, impilo yomzimba, i-fibrosis, i-mineralization yamathambo, kunye nokudumba.

Abaphandi banike iimpuku ezineenyanga ezingama-20 amanzi okusela aqulethe i-HK de zafa.

Iziphumo zibonise ukuba umndilili wobomi beegundane kwiqela lonyango lwe-HK ziinyanga ezingama-32.25, ngelixa umndilili wobomi beegundane kwiqela lolawulo laliziinyanga ezingama-28 kuphela. Unyango lwe-HK lwandisa ixesha lokuphila ngeenyanga ezi-4.25, kwaye ubude bobomi beempuku ezibhinqileyo kunye nenkunzi bandiswa kakhulu.

Uhlalutyo lwe-Histopathological yesikhumba, isibindi, izintso, kunye nemiphunga yeempuku zifumene ukuba unyango lwe-HK aluzange lubangele utshintsho kwiiparitha ze-hematopoietic okanye i-organ toxicity, ebonisa ukuba unyango lwe-HK lukhuselekile.

Ukongeza, unyango lwe-HK luphucule i-phenotypes yokuguga kwiimpuku xa kuthelekiswa nolawulo, kubandakanywa nemiba ye-hunchback, ukuphuhliswa kwethumba, kunye nesimo soboya bezilwanyana.

Ezi ziphumo zibonisa ukuba unyango lwe-HK lunokwandisa ubomi obunempilo kunye nokuphila ixesha elide kweempuku, kwaye akukho tyhefu ibonwayo.

Uhlalutyo olongezelelweyo lufumene ukuba unyango lwe-HK luphucule i-phenotypes yokuguga kwiintlobo ezahlukeneyo zezicubu, kubandakanywa ukulahleka kweenwele eziphuculweyo, ithambo, impilo ye-muscle kunye nokusebenza kwezintso.

Uhlalutyo lwe-Mechanism lubonise ukuba unyango lwe-HK luphantsi kakhulu-lulawule i-gene yokuguga isethi SAUL_SEN_MAYO, ngelixa i-up-regulated eguga iseti yemfuza idibaniswe nokugqithiswa kokuvuvukala, ukusebenza kwe-immune, kunye neendlela ezinxulumene neminyaka, ebonisa ukuba unyango lwe-HK luhlengahlengise iimpawu ze-transcriptome ezinxulumene nokuvutha nokuguga. Ukongezelela, uhlalutyo lwemisipha, ulusu, izintso, kunye nemiphunga lufumene ukuba unyango lwe-HK lunciphisa amanqanaba okumakisha ukuguga kwiiscuphe ezahlukeneyo emzimbeni.

Ukongeza kokuguga kwendalo, abaphandi bafumanise ukuba unyango lwe-HK lunokuthintela ukwaluphala kunye ne-cardiotoxicity ebangelwa liyeza le-chemotherapy i-doxorubicin, ngelixa ligcina isiphumo salo sonyango.

Ekugqibeleni, ngenxa yokuba i-HK isicatshulwa esiqulethe iindidi zezityalo, abaphandi bahlalutya izithako ezithile ezidlala indima yokuguga, kwaye iziphumo zibonise ukuba inxalenye ye-flavonoid, i-luteolin (Lut), isithako esisebenzayo se-HK yokuchasana nokuguga, ephucula ukuguga ngokuguqula intsebenziswano phakathi kwe-p16 kunye ne-CDK6.

Kuthatyathwe ndawonye, ????uphononongo lufumene isicatshulwa sendalo esinemiphumo yokuchasana nokuguga eyaphucula ukuguga kweseli kunye nezicubu, ukuphuculwa kweempawu ezinxulumene nobudala ezifana noboya, i-humpback, ukuqokelela kwamanqaku okuguga kunye nomonakalo we-DNA kwizicubu, kunye nokwandisa kakhulu ubomi bezilwanyana.