I-SAIB(sucrose isobutyrate acetate) yinxalenye yoxubo-mayeza olunemisebenzi emininzi.
I-SAIB(sucrose isobutyrate acetate) licandelo loxubo-mayeza elisebenza ngeendlela ezininzi. Ilulwelo lwe-viscous olulungiselelwe yi-esterification elawulwayo yeswekile yendalo (sucrose) kunye ne-acetic acid kunye ne-isobutyric anhydride. Ingumxube oveliswa yi-distillation kunye nemveliso ehlanjululwe kakhulu. Ingasetyenziselwa njengento eqhubekayo yokukhululwa kwe-agent, i-solvent / carrier kunye ne-inhibitor yokusetyenziswa kakubi kweziyobisi.
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Iimpawu zemveliso ye-SAIB
I-SAIB yi-solvent / carrier egqwesileyo ye-hydrophobic API kwaye inomsebenzi wokukhulula ngokukhawuleza.
I-SAIB ayikhazimli kwaye ihlala i-amorphous kwiqondo lobushushu begumbi, elikhuthaza kakhulu izinga eliqhubekayo lokuhanjiswa kweziyobisi;
I-SAIB ayiyo-polymeric kwaye ayijiki okanye ikhuphe xa idibana nolwelo olumanzi lomzimba. I-SAIB iyanyibilika kwizinyibilikisi ezininzi ze-organic kwaye iyahambelana nezinto ezininzi; I-SAIB inokusasazwa emanzini ngoncedo lwezinyibilikisi eziphilayo.
I-SAIB ineempawu ze-bioadhesive kwaye ingasetyenziselwa ukusetyenziswa kwe-transdermal, i-sublingual kunye ne-buccal patch.
Isicelo semveliso
- Libazise ukukhululwa
Kulo mfanekiso ungasentla, kunokubonwa ukuba i-SAIB inexabiso le-HLB malunga ne-5, ebonisa ukuba i-hydrophobic
- Isisombululo se-API sokunyibilika kwamanzi okungalunganga
I-Hydrophobic SAIB yi-solvent/carrier carrier ye-API ene-solubility embi yamanzi, kunye nokusetyenziswa kwe-SAIB kuphucula ukunyibilika kwamachiza anganyibilikiyo kwintengiso.
- Thintela ukusetyenziswa kakubi kweziyobisi
Ukusetyenziswa kwe-SAIB kwandisa ubungakanani besuntswana le-opioids ngexesha lokusila kwaye liphazamise ukukhutshwa kweziyobisi.
(1) Iipolymers (i-polyoxyethylene kunye / okanye i-hydroxypropyl methylcellulose) kunye ne-tocopherol acetate ziyi-granules ezenziwe kwisisombululo sotywala se-SAIB. Amalungiselelo ahlelwa njengaAbanganyangekanga/Abanganyangwanga okanye banyangelwe bubushushu/banyangekile (inyangelwe ngama-90oC kangangemizuzu engama-30).
(2) I-Pseudoephedrine hydrochloride, iipolymers (i-polyoxyethylene kunye / okanye i-hydroxypropyl methylcellulose) kunye ne-tocopherol acetate ziyi-granules ezenziwe kwisisombululo sotywala se-SAIB. Amalungiselelo ahlelwa njengaAbanganyangekanga/Abanganyangwanga okanye banyangelwe bubushushu/banyangekile (inyangelwe ngama-90oC kangangemizuzu engama-30).
Uvavanyo lokusetyenziswa kakubi kweempumlo lubonise ukuba ukusetyenziswa kwe-SAIB kwandise ubungakanani bepowder ngexesha lokugaya, ukuya kuthi ga kwi-47% yobukhulu bomgubo wokusila omkhulu kune-1mm.
Xa kuthelekiswa neqela lolawulo, inani lokukhutshwa kwe-SAIB emanzini, i-0.1% N HCl kunye ne-0.1% N i-solvents ye-NaOH yehle ngo-41.3% -42.5%, 24.8% -26.1% kunye ne-37.4% -50.6%, ngokulandelanayo. Ukusetyenziswa kwezinyibilikisi zendalo xa kutsalwa kuvelisa iintsalela ezincangathi ekunzima ukudlula kuzo ngeendlela ezahlukeneyo zolawulo (umz., inaliti, ukuginya, ukufutha, njl. njl.), ukuthintela ukusetyenziswa kakubi kweziyobisi.
isiphelo
Ukusetyenziswa kwe-SAIB, ngaphandle kokugquma, kunokuxutywa ngokuthe ngqo kunye ne-API ukwandisa ixesha lokukhululwa kweziyobisi kunye nokufezekisa ukukhululwa okuqhubekayo.
I-Hydrophobic SAIB, enokuthi isasazwe emanzini ngoncedo lwe-solvents eziphilayo, ingasetyenziselwa i-hydrophobic okanye i-hydrophilic apis; I-SAIB inokuphucula ukunyibilika kwe-API kunye ne-solubility embi yamanzi kwaye i-solvent egqwesileyo kunye ne-carrier ye-API ene-solubility embi yamanzi.
Ukusetyenziswa kwe-SAIB kuthintela ukusetyenziswa kakubi kweziyobisi ngokunyusa ubungakanani bamasuntswana echiza xa liphantsi, liphazamisane nokutsalwa kwechiza, kwaye kwenze kube nzima ukuba ichiza lifunxeke ngeendlela ezahlukeneyo zolawulo.
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http://86671.cn/factory-price-saib-sucrose-acetate-isobutyrate-product/