Youdaoplaceholder0 1.1 Umlingo womzimba we-viscosity gradient: Utshintsho oluphindwe kathathu ukusuka kwisisu ukuya kwikholoni

Ulwakhiwo lwemolekyuli ye-polyglucose iqulethwe ngamasalela eglucose adityanisiweyo ngokungacwangciswanga, kwaye oku kuhambelana okukhethekileyo kunika iipropathi ezikhethekileyo ze-rheological. Kwimeko ye-acidic kakhulu yesisu (pH 1.5-3.5), amakhonkco ayo eemolekyuli akhawuleza enze ulwakhiwo lwenethiwekhi ye-3-dimensional ngokusebenzisa iibhondi ze-hydrogen, kwaye i-viscosity inyuka ngokukhawuleza ukuya kwi-1200 mPa · s (malunga nokuphindwe kabini kobusi), ngokufanelekileyo ukulibazisa izinga lokukhupha isisu ngokufikelela kwi-40% yokuzala kunye nokuzala. Emva kokungena emathunjini amancinci, njengoko ixabiso le-pH linyuka ukuya kwi-6.0-7.5, ezinye iibhondi ze-hydrogen ziyaphuka kwaye i-viscosity yehla ukuya kwi-300-500 mPa · s. Ayithinteli kakhulu ukufunxa izondlo kwaye ayidibanisi ne-bile acids ukunciphisa izinga lokufunxa kwe-cholesterol. Xa ufikelela kwikholoni, phantsi kwesenzo se-microbial fermentation, i-viscosity iyancipha ngakumbi ukuya ngaphantsi kwe-50 mPa·s, ikhupha i-fatty chain fatty acids (SCFAs) ukubonelela ngamandla kwiprobiotics (Umfanekiso 1).

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Inkxaso yedatha ye-Youdaoplaceholder0 :

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Izinga lokulibaziseka lokukhupha isisu: 40% (Ukutya kweHydrocolloids 2022, n=30)

Izinga lokuthintela ukufunxwa kweCholesterol: 22% (idatha yesiqinisekiso seGRAS evela kwi-US FDA)

Ukonyuka kwemveliso ye-SCFAs: Uxinzelelo lwe-acetic acid ye-Colonic yanda amaxesha angama-3.8 (I-Gut 2023, i-Animal Model)

I-Youdaoplaceholder0 1.2 Isicwangciso "sokutya okuchanekileyo" se-microbiome

Ukulawulwa kwe-viscosity ye-polydextrose ayichaphazeli kuphela inkqubo yokugaya umzimba, kodwa iphinda yenza intsebenziswano eguquguqukayo kunye neentyantyambo zamathumbu. I-viscosity state ephezulu yenza umqobo womzimba kwi-colon proximal, ukunciphisa uqhagamshelwano phakathi kwebhaktheriya ye-pathogenic kunye ne-intestinal mucosa. Njengoko i-viscosity iyancipha, ngokuthe ngcembe iguqulela kwi-substrate evundileyo, ngokukodwa ivuselela ukwanda kwe-Bifidobacteria kunye ne-lactic acid bacteria. Iqela elivela kwiYunivesithi yaseCambridge lifumene ngokulandelelana kwe-metagenomic ukuba ukutya okuqhubekayo kwe-12g / ngosuku lwe-polydextrose kwiiveki ze-8 kunokwandisa umlinganiselo we-F / B we-Thick-miliae / Bacteroidetes ukuya kwi-1.3 (kunye nesiseko esiphilileyo se-1.5-2.0), kunye nokwandisa ubuninzi be-Family acid nge-5%. Esi siphumo esinezigaba ezimbini "sokukhusela kuqala, emva koko isondlo" sihlangabezana ngokugqibeleleyo neemfuno ze-ikholoji zamacandelo ahlukeneyo amathumbu emathumbu.

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Youdaoplaceholder0 Isahluko sesi-2 seSicelo seSicelo seNguqulelo: ukuNgenelwa komda onqamlezileyo ukusuka kukutya okuLawulweyo kweSugar ukuya kwi-ICU Nutrition

I-Youdaoplaceholder0 2.1 Ishishini lokutya: "I-skeleton engabonakaliyo" yeemveliso ze-GI ephantsi

Kwintsimi yokubhaka, umthamo ophezulu wokubamba amanzi (> 8g amanzi / g) kunye nokuzinza kwe-thermal (ukunyamezela kwi-200℃) ye-polyglucose yenza ukuba ibe yindawo efanelekileyo ye-sucrose. "I-Zero Sugar Cookies" eyasungulwa yiQela le-Meiji laseJapan isebenzisa i-polyglucose njenge-fiber engundoqo, ifumana kuphela i-1.2g ye-carbohydrates enetha kwikuki nganye, kwaye ukuthungwa kunye nokukhanya akuhlukanga kwiimveliso ezineswekile. Okubaluleke ngakumbi, ukulawulwa kwayo kwe-viscosity kumathumbu amancinci kunokulibazisa ukunyuswa kwe-glucose kunye nokunciphisa i-postprandial blood glucose peak nge-34% (idatha yeClinical esuka kwi-Diabetes Care 2021).

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Youdaoplaceholder0 Imeko entsha:

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Youdaoplaceholder0 Nestle : "I-Smart-release slow-release bar" iphuhliswe ngokuxuba i-polydextrose ene-dextrin exhathisayo ibonakalisa uyilo lwe-viscosity gradient eyandisa ukufunxwa kwe-carbohydrate ukuya kwiiyure ze-6, ukuhlangabezana neemfuno eziqhubekayo zokubonelela amandla kwiimbaleki zembaleki.

I-Youdaoplaceholder0 I-Nongfu Spring : Yaziswa "I-Intestinal Vitality Sparkling Water" kunye ne-polyglucose eyongeziweyo, esebenzisa ipropathi yayo ye-low-viscosity fermentation ukuvelisa igesi epholileyo kwikholoni ukuvuselela i-peristalsis yamathumbu. Ithengise ngaphezulu kwe-100 lezigidi zeebhotile kwiinyanga ezintathu.

I-Youdaoplaceholder0 2.2 Isondlo sonyango: "I-intestinal barrier Guard" kwizigulana zase-ICU

Ukungaphumeleli komqobo we-intestinal mucosal kwizigulane ezigula kakhulu zihlala zikhokelela kwizifo zesistim. Ulingo olulawulwa ngokungahleliwe (n = 158) olwenziwa yiSibhedlele sokuQala esiBambiseneyo seYunivesithi yaseZhejiang lubonise ukuba izigulane ze-ICU ezongezwa nge-15g ye-polyglucose imihla ngemihla zine-42% yehla kwi-endotoxemia kunye nokunciphisa i-29% kwi-intestinal permeability index (plasma ligonin). Umatshini ulele ekubeni i-high-viscosity state yenza ifilimu ekhuselayo kwisisu, ukunciphisa umngcipheko wezilonda ezibangelwa uxinzelelo. I-asidi ye-butyric ekhutshwe yi-colonic segment ikhuthaza ngokuthe ngqo ukutyeba kwe-mucus layer (ukwandisa inani leeseli ze-goblet ngama-37%), ukufezekisa ukuqiniswa komqobo wenyama kunye neekhemikhali ezimbini.

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Youdaoplaceholder0 Isahluko sesi-3 sokuPhumelela kwezobuGcisa: UkuPhuculwa ukusuka 'kwieFomula zeEmpirical' ukuya kwi-'Computational Nutrition '

Youdaoplaceholder0 3.1 Ulawulo oluchanekileyo lokuguqulwa kwemolekyuli

Uluhlu lwempendulo ye-viscosity ye-polydextrose yendabuko ilinganiselwe, okwenza kube nzima ukufanisa ngokuchanekileyo iimfuno zomntu ngamnye. NgoJuni ka-2023, i-DSM yaseNetherlands yabhengeza itekhnoloji enelungelo elilodwa lomenzi wechiza "i-PolySmart?", eyaphuhlisa izinto ezintathu ezahlukeneyo ze-viscosity curve ngokulawula iqondo lepolymerization (ixabiso le-DP) yeglucose kunye ne-sorbitol:

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Uhlobo lwe-Youdaoplaceholder0 G (uphuculo lwesisu) : I-Viscosity ukuya kwi-1500 mPa·s kwi-pH

Uhlobo lwe-Youdaoplaceholder0 C (ikholoni ekujoliswe kuyo) : I-Viscosity yehla ngokukhawuleza ukuya kwi-30 mPa·s kwi-pH> 6.5, ikhethwa ngabantu abanokuqhina;

I-Youdaoplaceholder0 Uhlobo lwe-B (imo elungeleleneyo) : Utshintsho olugudileyo lwe-viscosity yamathumbu onke, ilungele ulawulo lweswekile yegazi kwizigulana zeswekile.

I-Youdaoplaceholder0 3.2 Uyilo oluNcedo lwe-AI loKuqulunqa

Iqonga elithi "FiberEngine" eliphuhliswe yinkampani yakwa-Israel i-NutriAI idibanisa i-2 yezigidi zedatha ye-gut microbiota kunye nemodeli ye-fluid dynamics, enokuthi iqikelele umlinganiselo ochanekileyo wokongeza we-polydextrose phantsi kweminyaka eyahlukeneyo kunye neemeko zesifo. Ngokomzekelo, kwizigulane ezine-IBS (i-Irritable Bowel syndrome), inkqubo incoma ukudibanisa kwansuku zonke kwe-8-10g ye-polyglucose kunye ne-2g ye-fructooligosaccharides, eyanciphisa iziganeko ze-abdominal distension nge-65% (2023 idatha yokulandelela umsebenzisi).

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I-Youdaoplaceholder0 Isahluko sesi-4 sesiphithiphithi soShishino: "I-Fiber Blue Ocean" iZigebenga ezizilwelayo

Youdaoplaceholder0 4.1 Umdyarho womthamo uyatshisa

Ubungakanani bemarike ye-polydextrose yehlabathi kulindeleke ukuba ikhule ukusuka kwi-870 yezigidi zeedola zaseMelika ngo-2023 ukuya kwi-2.1 yeebhiliyoni zeedola zaseMelika ngo-2030 (CAGR 12.3%). I-China iye yaba yeyona ndawo iphambili yedabi.

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I-Youdaoplaceholder0 Baolingbao Bio : Tyala i-500 yezigidi zeeyuan ukwandisa iitoni ezingama-30,000 ngonyaka ngomgca wemveliso, usebenzisa inkqubo ye-enzymatic synthesis ukuphumeza ubunyulu obungama-99.5%;

Youdaoplaceholder0 Rogate : Iiprobiotic-polyglucose microcapsules eziphuhliswe ngentsebenziswano ne-CHR. UHansen unyuse izinga lokusinda kwi-asidi ukuya kuma-90%;

Youdaoplaceholder0 Matsuya Chemie, Japan : Yaziswa nge-"nano-fibrotic polyglucose," enovakalelo oluphindwe kathathu lwe-viscosity regulation kwaye inikwe igama lechiza lenkedama yi-FDA yesifo esifutshane samathumbu.

Youdaoplaceholder0 4.2 Imingeni emibini yolawulo kunye nokuqonda

Nangona i-polydextrose ivunyiwe njengefayibha yokutya yi-European Union, i-China kunye namanye amazwe, abathengi basenakho ukungaqondi kakuhle. Uphando olwenziwa yi-FMCG e-United States lubonisa ukuba kuphela i-28% yabathengi abangakwazi ukwahlula ngokuchanekileyo umahluko osebenzayo phakathi kwe-polydextrose kunye nesitashi esinganyangekiyo. Okubaluleke ngakumbi, ukuthatha ngokugqithisileyo (ngaphezulu kwe-50g / ngosuku) kunokubangela ukuphazamiseka kwesisu okanye kuphazamise ukufunxwa kweeminerali. Ishishini lifuna ngokungxamisekileyo ukuseka izikhokelo zedosi esemgangathweni.

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Youdaoplaceholder0 Isahluko 5 Ukujonga phambili: "Inethiwekhi yefayibha" ukusuka kwiGUT ukuya kwiMpilo yoMzimba

I-Youdaoplaceholder0 5.1 Ubungqina obutsha bolawulo lwe- brain-gut axis

Ekuqaleni kwe-2024, i-California Institute of Technology yafumanisa kwiimvavanyo zempuku ukuba i-asidi ye-butyric eveliswa ngokuvundiswa kwe-polydextrose inokuvuselela i-hypothalamic neurons ngokusebenzisa i-vagus nerve, ukunciphisa ukuziphatha okuxhalabisayo nge-43%. Oku kunika inkcazo yenqanaba le-molecular yebango lokuba "i-high-fiber diet iphucula impilo yengqondo".

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I-Youdaoplaceholder0 5.2 Izinto ezintsha eziphazamisayo kwi-Synthetic biology

Ukuqala kwe-US i-Zymergen isebenzise iteknoloji ye-CRISPR ukuguqula i-Trichia pastoris, eyenza ukuba ikhuphe ngokuthe ngqo "i-polyglucose ehlelwe ngofuzo" kunye ne-curve ye-viscosity eyenziwe ngokwezifiso. Le mveliso ibonise ukuphucuka kwe-80% kwimpendulo ye-pH echanekileyo kwiimvavanyo ezifaniswayo zokugaya kwaye kulindeleke ukuba zingene kwinqanaba lovavanyo lwekliniki ngo-2025.

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Youdaoplaceholder0 Isiphelo: Ukuchaza kwakhona "imida yobukrelekrele" yeFayibha

I-viscosity gradient effect ye-polydextrose ibonisa ixesha elitsha le-fiber yokutya, ukusuka "kwi-passive supplementation" ukuya "kumgaqo osebenzayo". Xa i-fiber component inokulawula ngokuzimeleyo umsebenzi wayo ekuphenduleni imeko ye-digestive tract, sinokubona utshintsho lwe-paradigm kwisayensi yezondlo-ungenelelo lwezempilo lwexesha elizayo alusayi kuba yimizamo yodwa ye-molecule enye, kodwa kunokuba umdaniso odibeneyo wezinto ezihlakaniphile, i-microbiome, kunye nobukrelekrele bokwenziwa. Njengoko owaphumelela iBhaso likaNobel kwiChemistry, uFrances Arnold, wakha wathi, "Iimolekyuli kwindalo sele zinamathuba angenasiphelo. Into ekufuneka siyenze kukufunda ukumamela 'ulwimi lwazo lwexesha nendawo'."