1. Izibonelelo zeempawu ze-metabolic kunye nokulawula i-glucose yegazi

1. Iikhalori zero kwaye akukho ntsalela ye-metabolic
Emva kokuba ulwakhiwo lwemolekyuli ye-sucralose yatshintshwa yi-chlorination, inkqubo yokwetyisa komntu ayikwazanga ukuyibolisa ibe yiswekile enokufunxa. Idatha yeklinikhi ibonisa ukuba malunga ne-85% ikhutshwe ngokuthe ngqo emathunjini emva kokungena, kwaye i-15% eseleyo i-metabolized ngesibindi kwi-non-toxic compounds kwaye ikhutshwe kumchamo 13. Le propathi iyenza ibe yinyani "zero calorie" isweetener, kungekho mthwalo wongezelelweyo wamandla kubantu abanesifo seswekile kwidosi yemihla ngemihla ukuya kuthi ga kwi-9mg/kg ubunzima bomzimba ?28.

2. Indlela yokuzinza kweglucose yegazi
Akukho luvuselelo lwe-insulin : Uphononongo luka-2024 olwenziwa yi-International Diabetes Federation (IDF) lubonise ukuba i-sucralose ayizange isebenze i-sweet taste receptor T1R2/T1R3 kwiiseli ze-beta ze-pancreatic kwaye ayizange ibangele ukukhutshwa kwe-insulin 57.
Kuphephe ukufunxa i-glucose : Ngokungafaniyo ne-sucrose, i-sucralose ayiphazamisi umsebenzi we-SGLT1 ye-glucose transporter kumathumbu amancinci, kunye nokusebenza kakuhle kwe-glucose emathunjini kugcinwa kwinqanaba eliqhelekileyo 36. Umzekelo, abantu abangama-50 abanesifo sikashukela sohlobo lwe-2 abasebenzisa iziselo ezine-sucralose kangangeentsuku ezingama-30 ezilandelelanayo babenokuguquguquka okungaphantsi kwe-0.3% kumanqanaba abo e-A1c (HbA1c) 5.
Okwesibini, ixabiso elisebenzayo lokulawula ukutya

1. Ukuba nokwenzeka kokutshintsha iiswekile zesintu
Ubumnandi be-sucralose buphindwe ngama-600 kune-sucrose, kwaye kuphela isixa esincinci esinokwanelisa iimfuno zencasa. Umzekelo:

Ukongeza i-30mg ye-sucralose kwi-300ml isiselo esingenashukela sinokufikelela ubumnandi obulingana ne-10% isisombululo se-sucrose 16;
Ukongeza i-15mg kwi-100g nganye yomgubo kwizinto ezibhakiweyo kunciphisa ukutyiwa kwe-sucrose malunga ne-45g 48.

2. Isiphumo sokuphucula isakhiwo sokutya
Nciphisa ukuxhomekeka kwekhabhohayidrethi : Ngokutshintsha iicarbohydrates zemveli, abanesifo seswekile banokunciphisa ukuthathwa kwekhabhohayidrethi imihla ngemihla ngama-50-80g, okulingana nokusika i-200-320kcal calories 27;
Ukuphuculwa kokwahluka kokutya okuphuculweyo : Ukonyuka kokwamkelwa kwezidlo zeswekile ngaphezulu kwe-40% ngokuvumela ukusetyenziswa okukhuselekileyo kokutya okuswiti okufana ne-ayisikrimu kunye nekhekhe 38.
Okwesithathu, umphumo wokuphepha weengozi zempilo

1. Thintela iingxaki zeswekile
Ukunciphisa umngcipheko we-caries yamazinyo : Iibhaktheriya zomlomo azikwazi ukuphula i-sucralose, kwaye iimpawu zayo zokulwa ne-caries zinciphisa izinga losulelo lomlomo nge-27% kubantu abanesifo seswekile 46;
Ukukhusela inkqubo ye-cardiovascular system : Emva kokutshintsha i-sucrose, amanqanaba e-triglyceride yezigulane ehle ngomyinge we-0.4mmol / L kunye ne-low-density lipoprotein (LDL) iyancipha nge-12% 78.

2. Ukuziqhelanisa neemeko ezizodwa
Uzinzo lobushushu obuphezulu : xa ubhaka ngaphantsi kwe-120℃, i-sucralose ayiyi kuvelisa iimveliso ezinetyhefu ezifana ne-chloropropanol, elungele ukwenza iipastries ezineswekile ephantsi ?38;
Ukuhambelana neziyobisi : akukho ukusebenzisana kunye neziyobisi ze-hypoglycemic ezisetyenziswa ngokuqhelekileyo ezifana ne-metformin kunye ne-insulin, kodwa kufuneka zithathwe kunye neziyobisi ze-anticoagulant ezifana ne-warfarin 27 kwisithuba seyure ye-2.
Okwesine, iinzuzo zengqondo nezentlalontle

1. Ukuphucula umgangatho wobomi
Izigulane ezinesifo seswekile zine-62% yokunciphisa uxinzelelo lwengqondo ngenxa yokungabikho okumnandi kunye ne-avareji ye-3.2 yokunciphisa i-Depression Scale (PHQ-9) amanqaku 68. Uphando lwaBathengi lwango-2024 lubonise ukuba ukwaneliseka kokutya phakathi kwabantu abanesifo seswekile abasebenzisa i-sucralose njengendawo yeswekile kunyuke ukusuka kwi-43% ukuya kwi-79% 3.

2. Ukulungiswa kweendleko zoqoqosho
Ukunciphisa inkcitho yonyango : kunokunciphisa iindleko zonyango lonyaka lwesifo seswekile, i-retinopathy kunye nezinye iingxaki malunga ne-3200 yuan / umntu 78;
Ukuveliswa kweshishini lokutya: Ukukhuthaza imakethi yokutya okungenaswekile ukuba ikhule nge-18% ngonyaka kwaye kulindeleke ukuba ifikelele kwi-120 yeebhiliyoni zeeyuan 14 ngo-2025.

5. Iinkcukacha zesicelo kunye nethemba elizayo

1. Imigaqo yokusetyenziswa kwenzululwazi
Ulawulo lwedosi : Landela i-WHO ecetyiswayo umda ophezulu we-9mg / kg ubunzima bomzimba wemihla ngemihla (malunga ne-540mg yabantu abadala be-60kg) 28;
Ukukhetha inkqubo : iimveliso zetekhnoloji ye-microencapsulation ziye zakhethwa ukunciphisa impembelelo kwizityalo zamathumbu (izinga lokuncipha komsebenzi we-bifidobacterium liye lancitshiswa ukusuka kwi-30% ukuya kwi-8%) 18.

2. Isikhokelo sophuhliso lwetekhnoloji
Itekhnoloji yokulawula ukuchaneka : Inkqubo "ye-chlorination ekhokelwayo" ephuhliswe yiJinhe Industry ngo-2025 inciphisa intsalela ye-chloropropanol kwi-0.01ppm8;
Uphando lwezonyango olusekwe kubungqina : I-International Diabetes Association isungula uphando lwabantu abayi-100,000 ukuvavanya iziphumo zexesha elide ze-sucralose kwi-islet function 56.
isiphelo
I-Sucralose inika abaguli abanesifo seswekile isisombululo esilungelelanisa iimfuno zencasa kunye nolawulo lwezempilo. Amanani ayo angundoqo afakwe kwi-inertia ye-metabolic, ukuzinza kwe-glucose yegazi kunye nokuthintela iingxaki. Ngeenkqubo eziphuculweyo zokuvelisa (ezifana neteknoloji ye-microencapsulation) kunye neenkqubo eziphuculweyo zokulawula (ezifana nokuhlaziywa kweZikhokelo zokuBhaliswa kweZondlo zaseChina kwi-Pre-Packaged Foods ngo-2025), i-sucralose iya kuba sisixhobo esikhuselekileyo nesisebenzayo sokulawula ukutya kwesifo sikashukela. Nangona kunjalo, kufuneka kugxininiswe ukuba indawo yeswekile ayinakuthatha indawo yesiseko sokutya okunokulinganisela kunye nonyango lokuzivocavoca, kwaye ukusetyenziswa kwesayensi kufuneka kusekelwe kwisikhokelo sonyango lomntu ngamnye.