Isiphumo sokuchasana nokudumba kwevithamin E sifumaneka ikakhulu ngeendlela ezininzi ze-synergistic, kwaye indlela ethile yile ilandelayo:

1. Ukuthintela indlela yokubonakalisa ukuvuvukala
I-Vitamin E yandisa amanqanaba e-sphingolipid, isebenze i-protein e-anti-inflammatory A20, ivimba i-TNF - i-α - i-activation ye-NF - κ B indlela yokubonisa indlela, ngaloo ndlela inqanda ukubonakaliswa kwe-NF - κ B iprotheni kunye nokunciphisa ubuninzi bempendulo yokuvuvukala.
I-NF - κ B yinto ephambili yokubhala elawula i-cytokines e-pro-inflammatory, kunye nokuvinjelwa komsebenzi wayo kunokunciphisa ukuveliswa kwabalamli abavuthayo.
2. Ukunciphisa i-radicals yamahhala kunye nokunciphisa uxinzelelo lwe-oxidative
I-Vitamin E inqanda ngokungathanga ngqo iimpendulo zokuvuvukala ezinxulumene noxinzelelo lwe-oxidative ngokucoca i-radicals yamahhala kunye nokunciphisa umonakalo weselula obangelwa kuxinzelelo lwe-oxidative.
3. Ukuthintela ngokuthe ngqo ukukhululwa kwabalamli abavuthayo
Ukuthintela ukukhululwa kwe-pro-inflammatory kunye ne-chemokines ngamaseli avuthayo afana ne-neutrophils kunye ne-macrophages, kunye nokunciphisa iimpendulo ezivuthayo zezicubu zendawo.
Ukunciphisa ukuveliswa kweemveliso ze-lipid peroxidation (ezifana ne-malondialdehyde) kwaye ugweme ukuvuselela kwabo ukuvuvukala kwesignali ye-cascade amplification.
4. Ukulawula ukusebenza kweeseli zomzimba
Ukuphucula umsebenzi wokuchasana nokuvuvukala kweeseli zomzimba, ezifana nokuthintela iiseli ze-T kunye ne-B ezigqithisileyo, kunye nokulinganisa iimpendulo zomzimba.
Khusela i-membrane yesakhiwo seeseli zokuzivikela, ugcine umsebenzi wabo oqhelekileyo, kwaye uthintele ukuphendula okungalawulwayo okuvuthayo.
Ukusetyenziswa okuthe ngqo kweempembelelo ezichasayo
Ukuvuvukala kwesikhumba: Nciphisa ubomvu besikhumba kunye nokuvuvukala okubangelwa yimisebe ye-ultraviolet okanye i-stimuli yangaphandle, inqanda umsebenzi we-tyrosinase, kunye nokunciphisa umngcipheko we-pigmentation.
Isifo esingapheliyo sokuvuvukala: sinokunceda ukukhulula i-arthritis, i-atherosclerosis kunye nezinye iimpawu zezifo ezingapheliyo ezinxulumene nokuvuvukala