Amandla e-mannose kummandla woxubo mayeza agxininiswe ikakhulu kumacala athile athile, amanye awo sele esetyenzisiwe ekliniki (njengothintelo losulelo lwendlela yomchamo), ngelixa ezinye zikuphando olusisiseko okanye isigaba sokuqala solingo lwezonyango. Amathemba afanele ukuba anikwe ingqwalasela, kodwa ubungqina obuninzi obufunekayo ukuze kuxhaswe. Chaza amandla ayo kwezi ndawo zilandelayo:

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1, Imimandla yeSicelo eQwalaselelweyo/eQlileyo

Ukuthintela ukosuleleka rhoqo komjelo womchamo (rUTI) ?

I-Mechanism: Ulawulo lomlomo lwe-mannose luphumela ekukhunjweni okuphezulu kumchamo, ngokukhuphisana ukuthintela ukubophelela kwe-FimH pilin adhesin ukusuka kwi-pathogens efana ne-Escherichia coli ukuya kwiiseli ze-epithelial zesinye, ukuthintela ibhaktheriya ekubeni ikoloni kwaye ihlanjwe ngumchamo.

Ubungqina:

Izifundo ezininzi zeklinikhi, ezifana nokuthelekisa kunye ne-furantoin ye-antibiotic, ibonise ukuba i-1.5-2g ye-mannose ngosuku iyasebenza njenge-antibiotics ye-dose ephantsi ekukhuseleni i-rUTI ebangelwa yi-Escherichia coli kubasetyhini, kwaye inomngcipheko ophantsi wokumelana.

Izikhokelo ze-European Association of Urology (EAU) ziluhlu njengenye indlela yokuthintela i-rUTI (iNqanaba loBubungqina: B).

Izinto eziluncedo: Ukhuseleko oluphezulu (iziphumo ebezingalindelekanga zesisu), akukho mngcipheko wokunganyangeki kwe-antibiotics.

Unyino: Isebenza kuphela ekuthinteleni kwaye ayinakuthatha indawo ye-antibiotics kunyango lwezifo ezinzima; Isiphumo kwi-non Escherichia coli UTI silinganiselwe.

I-2, Iindawo ezikwinqanaba lophando kodwa zinamandla acacileyo

Unyango lwe-Congenital Glycation Disorder (CDG)

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I-Mechanism: Ezinye ii-CDG subtypes, ezifana ne-MPI-CDG (uhlobo lwe-CDG-Ib), ukungabikho kwe-phosphomannose isomerase (PMI), ethintela ukuguqulwa kwe-mannose-6-phosphate kwi-fructose-6-phosphate, ekhokelela ekuhlulekeni kwamalungu amaninzi.

Unyango: Ukulawulwa komlomo we-mannose kunokudlula iziphene ze-PMI kunye nokubonelela ngokuthe ngqo i-mannose-6-phosphate, ukubuyisela i-glycoprotein synthesis.

Imeko yangoku:

I-FDA ivume ukusetyenziswa kwe-mannose ye-MPI-CDG, enye yee-subtypes ezimbalwa ezinyangekayo ze-CDG.

Ukuphucuka okubonakalayo kwisifo sesibindi, ukungasebenzi kakuhle kwe-coagulation, kunye neempawu zesisu, kodwa amayeza obomi bonke ayafuneka.

Okunokwenzeka: Phonononga ixabiso lonyango lwe-adjuvant kwezinye ii-CDG subtypes, ezifana ne-ALG-CDG.

I-Antitumor immune regulation kunye nokuhanjiswa kweziyobisi ???? (Uphando olusebenzayo lwangaphambili)

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Inkqubo:

I-tumor microenvironment ekujoliswe kuyo: I-Tumor ehambelana ne-macrophages (i-TAMs) ichaza kakhulu i-mannose receptors (i-MRC1), kunye neziyobisi eziguqulwayo ze-mannose zinokuhanjiswa kumathumba ngendlela ejoliswe kuyo.

Ukulawula ukunyanzeliswa kwe-immune: I-Mannose ngokukhuphisanayo inqanda i-mannose receptors kumphezulu we-TAMs, ivimbela ukuqaphela kwabo i-mannose glycated antigens kumphezulu weeseli ze-tumor, ezinokuthi ziguqule ukunyanzeliswa komzimba.

Ukwandiswa kwe-chemotherapy sensitivity: Kwizifundo zezilwanyana, indibaniselwano yemannose kunye nechemotherapy (efana ne-doxorubicin) inokuthintela kakhulu ukukhula kwethumba (mhlawumbi ngokuphazamisana ne-glucose metabolism).

Umngeni: Uphando olongezelelweyo luyafuneka ekusebenzeni komntu, idosi efanelekileyo, kunye neenkqubo zokuhanjiswa.

I-Antifungal/antiparasitic usulelo adjuvants ??

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Inkqubo: Iintsholongwane ezifana neCandida albicans kunye nePlasmodium zixhomekeke kwi-host mannose receptors ukuba zihlasele iiseli. Imannose inokukuthintela ukunamathela kwayo.

Uphando:

Iimodeli ze-in vitro kunye nezilwanyana zibonise ukuba i-mannose inokuthintela ukunamathela kwe-Candida kwiiseli ze-epithelial.

Ukusetyenziswa okudityanisiweyo namayeza okulwa nesifo seengcongconi kunokunciphisa izinga losulelo lwezifunxi-gazi zemalariya (uvavanyo lwezilwanyana).

Okunokwenzeka: Njengesincedisi sokwandisa ukusebenza kakuhle kwamachiza asele ekhona angosuleli kunye nokunciphisa ukunganyangeki ngamachiza.

3. Izalathiso zokuphonononga ezivelayo (ezinokuthi ziqinisekiswe)

Isifo se-inflammatory bowel (IBD) kunye nokulungiswa komqobo wamathumbu ??

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Ucingelo:

I-Mannose inokulawula i-gut microbiota (ukukhuthaza ibhaktheriya enenzuzo) kwaye inqanda ukunamathela kwebhaktheriya ye-pathogenic.

Ukuphucula umsebenzi we-intestinal mucosal barrier proteins ngokuguqulwa kwe-glycosylation.

Imeko yangoku: Iimodeli zezilwanyana (i-colitis) zibonisa iziphumo ezithile zokukhusela, kodwa uphando lwabantu alukho.

Ukulawulwa kwezifo ze-autoimmune ??

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Ithiyori: I-glycosylation engaqhelekanga ibandakanyeka kwi-pathogenesis ye-rheumatoid arthritis, lupus, kunye nezinye izifo. I-Mannose supplementation ingalungisa iziphene ze-glycosylation.

Inkqubela: Ijongwa kuphela kwiimodeli zeeseli okanye kwinani elincinci kakhulu leemeko, ngaphandle kolingo olungqongqo lwezonyango.

Ukuthintela iingxaki zesifo seswekile ??

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Ingqiqo: Iswekile ephezulu yegazi ikhokelela ekugqithiseni i-non-enzymatic glycation (AGEs) yeeprotheni, ezibangela iingxaki. I-Mannose metabolism ayixhomekeke kwi-insulin kwaye ayichaphazeli i-glucose yegazi, okanye inokunciphisa ngokukhuphisanayo ukubunjwa kwe-AGEs.

Ubungqina: Uvavanyo lwezilwanyana lubonisa ukuba inkqubela ye-diabetes nephropathy iyancipha, kwaye uphando lwabantu alunanto.

4. Imingeni kunye nemida

Imingeni ephambili ebaleni

Uthintelo lwe-UTI alusebenzi ngokuchasene ne-non Escherichia coli pathogens; Idatha yokhuseleko yexesha elide ayonelanga (ingakumbi ifuthe lomsebenzi wezintso)

Unyango lwe-CDG lusebenza kuphela kwiintlobo ezincinci ezithile; Ukuxilongwa kwangoko kunye namayeza obomi bonke ayafuneka

Ukusebenza konyango lwe-tumor emzimbeni womntu akwaziwa; Amanani aphezulu anokubangela urhudo; Umngcipheko wetyhefu wokudibanisa ichemotherapy kufuneka uvavanywe

Ukungasebenzi ngokwaneleyo kokusetyenziswa okukodwa kwe-anti-infective adjuvants; Kufuneka kunyuswe unyango oludityanisiweyo namachiza asele ekhona

Uphando olubuthathaka kwiindlela ezikweminye imimandla evelayo; Ukunqongophala kwezilingo zeklinikhi ezikumgangatho ophezulu; Uninzi lwazo luhlala kwisigaba somzekelo wezilwanyana

5. Umkhombandlela wophuhliso lwexesha elizayo

Uphuhliso lwenkqubo yonikezelo oluchanekileyo: Yila i-mannose eguqulelwe kwi-nanocarriers ukuphucula i-tumor / isilonda esosulelayo ekujoliswe kuyo.

Ukuphucula unyango oludityanisiweyo: ukuhlola iziphumo ze-synergistic ye-mannose kunye ne-antibiotics, i-immune checkpoint inhibitors, kunye neziyobisi ezichasayo.

Ukwandiswa kweSifo esinqabileyo: Ukuhlolwa kwe-CDG subtypes eninzi kunye nokuphazamiseka kokugcinwa kwe-lysosomal enokuphathwa nge-mannose.

Ukuqulunqwa kwexesha elide lokukhupha: kusombulula ingxaki yamayeza rhoqo (njengokusetyenziswa kwansuku zonke ekuthinteleni i-UTI).

Isicwangciso sokucwangciswa kwabantu: amayeza achanekileyo asekelwe kuhlobo lwe-pathogen (UTI) okanye ukuguqulwa kofuzo (CDG)