Ca HMB, igama elipheleleyo i-β-hydroxy-β-methylbutyrate calcium, yenye yeendlela eziqhelekileyo ezongezelelweyo ze-HMB (β-hydroxy-β-methylbutyrate). I-Beta-hydroxy-beta-methylbutyric acid (HMB) ifumaneka ngokubanzi kwiziqhamo ze-citrus kunye nemifuno ethile efana ne-broccoli, i-legumes efana ne-alfalfa, kunye neentlanzi ezithile kunye nokutya kwaselwandle. I-β-hydroxy-β-methylbutyrate calcium (Ca HMB) ityuwa ye-calcium ye-β-hydroxy-β-methylbutyrate (HMB). Ngenxa yobume obusebenzayo be-HMB, ukwenzela ukuba kube lula ukugcinwa kunye nokusetyenziswa, ngokuqhelekileyo iguqulwa ibe yityuwa ye-calcium xa idibanisa, kwaye icandelo eliphambili le-HMB livela kwi-77-82%.

I-HMB yi-metabolite ephakathi ye-amino acid leucine ebalulekileyo yomntu, kwaye umzimba womntu unokuvelisa inani elincinci le-HMB ngokwayo. Ukutya okuqhelekileyo, umzimba womntu uvelisa malunga ne-300 ukuya kwi-400 mg ngosuku, apho i-90% ivela kwi-catabolism ye-leucine. I-HMB ingasetyenziselwa ukukhuthaza ukukhula kwemisipha, ukuphucula ukukhuseleka, ukunciphisa i-cholesterol kunye namanqanaba aphantsi e-lipoprotein ephantsi emzimbeni ukunciphisa ukuvela kwesifo senhliziyo kunye nesifo senhliziyo, kodwa nokuphucula amandla okulungisa i-nitrogen yomzimba, ukugcina amanqanaba eprotheni emzimbeni, kunye nokuthintela ukubola kwemisipha kwizigulane ezilele ebhedini okanye ezikhubazekileyo. Kwiminyaka yakutshanje, kuba inokunciphisa umonakalo wezicubu ze-muscle emva kokuzivocavoca, ukulungisa imicu ye-muscle, ukwandisa amandla emisipha kunye nokutshisa amanqatha omzimba, ibe yinto eyinkwenkwezi kwimveliso yezondlo zezemidlalo. Ukongeza, i-HMB ibonakaliswe ngokweklinikhi ukukhawulezisa ukuphiliswa kwenxeba kunye nokuthintela ukudumba. Uphononongo lubonise ukuba i-Ca HMB inokukhawulezisa ukuhlanganiswa kweeprotheyini kunye nokunciphisa ukusetyenziswa kweeprotheyini. I-Ca HMB idityaniswe ne-glutamine kunye ne-arginine inokuphucula ibhalansi ye-nitrogen engalunganga yezigulane kwaye idlale indima efanelekileyo ekubuyiseleni kwintlungu kunye nokuhlinzwa.

Ngo-2011, owayesakuba nguMphathiswa wezeMpilo wase-China wabhengeza imvume ye-β-hydroxy-β-methylbutyrate calcium.Ca HMB) njengokutya kobutyebi obutsha, ukusetyenziswa kokutya okunomsoco wezemidlalo, ukutya okukhethekileyo kweyeza zonyango, isixa esicetyiswayo ngu-≤3 grams / ngosuku. Kwi-2017, iKomishoni yeSizwe yezeMpilo kunye noCwangciso lweNtsapho yazisa ukwandiswa komda wesicelo se-Ca HMB ukusuka kwizicelo ezimbini zokuqala ukuya kwisithoba, kwaye yagunyazisa amaziko obuchwepheshe bovavanyo lomngcipheko ukwenza uvavanyo lokhuseleko. Ukusetyenziswa kwe-Ca HMB kwandiswe ukubandakanya iziselo, ubisi kunye neemveliso zobisi, iimveliso ze-cocoa, i-chocolate kunye neemveliso zetshokolethi, i-candy, izinto ezibhakiweyo, kunye nokutya okukhethekileyo kokutya, kwaye isixa esicetyiswayo sasise-≤3 g / ngosuku, engazange idlule i-dosage yamavolontiya olingo lwabantu. I-Ca HMB yaqatshelwa njenge-GRAS yi-US Food and Drug Administration ngo-1995 kwaye isetyenziselwa ukutya kwezonyango kunye nokutya okukhethekileyo. Kwiminyaka engama-20 edlulileyo, i-Ca HMB isetyenziswe ngokubanzi kwiimveliso zobisi, iimveliso zetshokolethi, iziselo, imivalo yamandla kunye nokunye ukutya kwimarike yase-US. I-Ca HMB yinto yokutya ekrwada evunyelwe yimimiselo yaseJapan, enokongezwa kwiinkalo ezininzi ezifana nokutya okuqhelekileyo, ukutya okunomsoco wezemidlalo, ukutya okunciphisa umzimba, ukutya okunobuhle, njl. Kubavelisi kunye neekhemesti, i-Ca HMB ngoku yenye yezona zithako zezempilo ezidumileyo kwimarike yaseJapan.

I-HMB isetyenziswa ngokubanzi kwiziselo eziqinileyo, kwaye iimveliso ezinjalo zikwaninzi kakhulu kwiimarike zamazwe ngamazwe. Ngokomzekelo, uJuven uqaliswe ngu-Abbott ukukhuthaza i-protein synthesis, i-Myoplex Muscle Armor iqaliswe yi-EAS e-United States, i-Fracora yempilo ye-muscle ephakathi kunye neyobudala eveliswe yi-Concord eJapan, njl., zonke zisekelwe kwi-HMB njengeyona nto ingundoqo. Kwiziselo ezimanzi ze-HMB, isicelo sasekhaya sikwinqanaba lokuqala, kodwa iinkampani zangaphandle zisisebenzisile kwaye zikwinkqubo yophuhliso oluthe chu. Umzekelo, isiselo sezemidlalo i-SUISPO yasungulwa yinkampani yaseJapan i-ISDG, kunye nolwelo lomlomo lobuhle olwenziwa yiJapan Concord. Njengokutya okutsha okutsha okunokongezwa kwiziselo, i-HMB inokudibaniswa neentlobo zeeprotheyini, ezifana ne-whey protein concentrate, i-protein ye-milk concentrate, i-whey protein isolate, kunye neprotheni yemifuno, kwaye ingasetyenziselwa kunye ne-vitamin kunye ne-mineral formulations ukwandisa ukusebenza kwemveliso. Ubisi olululwelo kunye nomgubo wobisi kunye ne-HMB ingasetyenziselwa abantu abaneminyaka ephakathi kunye nabantu abadala ukunceda ukukhusela ukubola kwemisipha, kwaye ingasetyenziselwa abantu bezemidlalo kunye nokuqina ukuze babonelele ngezondlo zemisipha. Ukongeza, enye iyogathi esebenzayo kwimarike, ukongeza i-HMB inokuphucula ingqikelelo yemveliso yantlandlolo kwaye ibonelele ngombono wokunciphisa amanqatha kunye nokubunjwa kwemilo, kunye nokongeza imathiriyeli ekrwada esebenzayo kwi-ayisikrimu ikwayindlela entsha yabaninzi abavelisi be-ayisikrimu bangaphandle. Ukongeza izithako ze-HMB kunokomeleza ukusebenza kwe-ayisikrimu kwisiseko sokuqinisekisa incasa kunye nencasa. Ukongeza, i-HMB ingasetyenziselwa kwimivalo yesondlo kunye neelekese, ezifana neyona mveliso idumileyo yebar yesondlo yi-Maximuscle, eyongeza i-20 grams yeprotheni, i-3.4 grams ye-creatine monohydrate kunye ne-1.6 grams ye-HMB, epapashwe ukunciphisa i-protein breakdown, yakha imisipha ngelixa ikhuthaza ukubuyiswa kwasemva kokuzivocavoca. Abaphuhlisi bokutya belahleko yamafutha kudala bafaka i-HMB kwilekese, njengenkampani yaseJapan i-ISDG evelisweHMBilekese, nto leyo ilekese kubantu abakha izihlunu kwaye balahlekelwe ngamafutha.

Njengongenelelo olusebenzayo lwezondlo kuthintelo kunye nonyango lwe-muscular decay syndrome,HMBiye yaqinisekiswa linani lezifundo zeklinikhi, kwaye i-HMB ibonakaliswe ngokweklinikhi ukukhawulezisa ukuphiliswa kwenxeba kunye nokuthintela ukuvutha. Okwangoku, uphuhliso kunye nokusetyenziswa kwe-HMB kwintsimi yokutya yasekhaya sele iqalile, kodwa ngokususwa kwemiqobo yokulawula yasekhaya, kunye nokunyuka kunye nokukhuthazwa kokutya okusebenzayo kwe-HMB kwimarike yehlabathi, kukholelwa ukuba kwixesha elizayo elingekude, i-HMB iya kuba nethemba lophuhliso olubanzi kwintsimi yesicelo sokutya.