I-Vitamin B3, eyaziwa ngokuba yi-niacin, yivithamin enyibilikayo emanzini eyenza imisebenzi eyahlukeneyo ebalulekileyo yomzimba. Uphononongo lwakwangoko lubonise ukuba ivithamin B3 ithatha inxaxheba kwinkqubo yemetabolism yamandla omzimba, ikhuthaza imetabolism yeeseli zesikhumba, kwaye inesiphumo esithile sokulwa ne-antioxidant.

Isifo sesibindi esinamafutha e-non-alcoholic (NAFLD), sesona siganeko siphezulu sohlobo lwesifo sesibindi esingapheliyo e-China, kukho ngaphezu kwe-150 yezigidi zezigulane e-China, apho i-10-20% iya kukhula ngakumbi ibe yi-non-alcoholic steatohepatitis (NASH), ebonakaliswa ngokukrala kunye nomonakalo weseli yesibindi, ehlala ihamba ne-fibrosis. I-NASH iqhubela phambili ngokukhawuleza kwaye inomngcipheko ophezulu wokuphuhlisa izifo ezinzulu zesibindi ezifana ne-cirrhosis kunye nomhlaza wesibindi.

Kutshanje, abaphandi abavela kwiSikolo seMpilo yoLuntu kwiYunivesithi yaseSun Yat-sen bapapashe iphepha kwiphephancwadi I-JAMA Network Open enesihloko esithi "I-Dietary Niacin Intake and Mortality among Individuals With Nonalcoholic. Isifo sesibindi esinamafutha "iphepha lophando.

Uphononongo lubonise ukuba ukuxhaswa nge-vitamin B3, okanye ukunciphisa umngcipheko wokufa kwizigulane ezine-non-alcoholic fatty disease, zidibene nokunciphisa i-30% kwingozi yokufa kwayo yonke into kubathathi-nxaxheba abanokuthathwa okuphezulu (≥26.7mg / ngosuku) xa kuthelekiswa nabathathi-nxaxheba abanomlinganiselo ophantsi kakhulu we-18 ≤ ngosuku.

Kolu phononongo, abaphandi bahlalutya umbutho phakathi kokutya kwe-vitamin B3 kunye nomngcipheko wokufa kwezigulane ezine-non-alcoholic fatty disease ngokuqokelela i-vitamin B3 yokutya kwi-National Health and Nutrition Examination Survey (NHANES) i-database ye-4,315 i-NAFLD izigulane ezineminyaka eyi-53 ubudala.

Abathathi-nxaxheba bahlulwe ngamaqela amathathu ngokusekelwe kwi-vitamin B3 yokuthatha: iqela eliphantsi lokuthatha (≤18.4mg / ngosuku), iqela eliphakathi lokuthatha (18.5-26.6mg / ngosuku) kunye neqela eliphezulu lokuthatha (≥26.7mg / ngosuku).
Ngethuba lokulandelwa kwexesha eliqhelekileyo leminyaka eyi-8.8, inani lokufa kwe-566 lirekhodwa, i-197 yalo ibangelwa sisifo senhliziyo.

Uhlalutyo lufumene ukuba abathathi-nxaxheba abanokuthathwa okuphezulu babenepesenti ze-30 ezisezantsi zomngcipheko wokufa xa kuthelekiswa nabathathi-nxaxheba abanokungena okuphantsi.

Ukongezelela, abathathi-nxaxheba abanokuthathwa okuphezulu babenokunciphisa ipesenti ze-35 kwingozi yokufa kwe-cardiovascular death, kodwa oku kwakungabalulekanga ngokwezibalo.

Uhlalutyo olongezelelweyo lufumene intsebenziswano ebalulekileyo phakathi kokuthatha i-vitamin B3 kunye nomngcipheko wesifo seswekile kunye nayo yonke into ebangela ukufa, kunye nokunciphisa okukhulu kokufa kwizigulane ezingenasifo seswekile xa kuthelekiswa nalabo abanesifo seswekile.

Ngokutsho kwabaphandi, i-niacin yenye ye-precursors ye-NAD synthesis kwaye ibe yinto ekujoliswe kuyo ebalulekileyo yokukhusela kunye nokunyangwa kwesifo sesibindi. Izifundo zongenelelo lwabemi ziye zabonisa ukuba i-niacin inokuphucula isibindi esinamafutha kunye nokunciphisa umxholo wesibindi. Kwizifundo zangaphambi kweklinikhi, i-niacin ifunyenwe inqanda kwaye ibuyise umva i-steatosis yesibindi kunye nokudumba, kunye nokuthintela i-fibrosis. Ezi ziphumo zifezekiswa ngokunciphisa uxinzelelo lwe-oxidative, inhibiting diacylglyceryl acyltransferase 2 kunye nomsebenzi we-NADPH oxidase, kunye nezinye iindlela ezinokwenzeka.

Kuyafaneleka ukukhankanya ukuba ngoSeptemba 2023, Abaphandi abavela kwiSikolo seMpilo yoLuntu kwiYunivesithi yase-Sun Yat-sen bapapasha iphepha kwiphephancwadi i- Nutrients enesihloko esithi "Umanyano phakathi kwe-Dietary Niacin Intake kunye ne-Nonalcoholic Fatty Liver Disease: NHANES 2003-2018 "iphepha lophando.

Uphononongo lubonise ukuba ukuxhaswa kwe-vitamin B3 kwakunxulumene nomngcipheko ophantsi we-non-alcoholic fat fat disease, kunye nalabo abane-niacin intake ephezulu (≥29.2mg / ngosuku) abanomngcipheko ophantsi we-31% we-noncoholic fatty disease yesibindi xa kuthelekiswa nalawo anenani eliphantsi le-niacin intake (≤16.3mg / ngosuku).

Kuthatyathwe kunye, iziphumo zibonisa ukuba i-vitamin B3 yokuncedisa idibene nomngcipheko ophantsi wesifo sesibindi esinamafutha angenasinxilisi kunye nomngcipheko oncitshisiweyo wezinto zonke zokufa kwizigulane ezine-non-alcoholic fatty disease. Uphando olongezelelweyo luyafuneka ukuze kuqinisekiswe idosi efanelekileyo ye-vitamin B3 ukunciphisa umngcipheko wokufa kwezigulane ezine-NAFLD.