Isifo sesibindi esinxilisayo (ALD), esisisifo sesibindi esibangelwa ukusela kakhulu ixesha elide, sesinye sezifo zesibindi eziqhelekileyo e-China, kubandakanywa nesibindi esinxilisayo, i-alcohol hepatitis, i-alcohol fibrosis kunye ne-cirrhosis yotywala. Kwiminyaka yakutshanje, ukuxhaphaka kwesifo sesibindi esinxilisayo kubonise ukunyuka okunyukayo e-China.

NgoJulayi 2, 2024, uLiu Zhihua weYunivesithi yaseTsinghua, uWang Hua weYunivesithi yezoNyango yase-Anhui, uYin Shi weYunivesithi yeSayensi kunye neTekhnoloji yaseTshayina kunye nabanye abaphandi bapapasha inqaku elinesihloko esithi "Ifayibha yokutya inciphisa ukwenzakala kwesibindi esinxilisayo nge" kwijenali yeCell Host & Microbe "Bacteroides acidifacification ammonia sub".

Ukutya okutyebileyo kwi-fiber yokutya e-soluble kwafunyaniswa ukwandisa ubuninzi be-B. accidifaciens kunye nokunciphisa ukulimala kwesibindi esibangelwa utywala kwiigundane.

Kumatshini, i-B.accifaciens ilawula i-bile acid metabolism nge-bile saline hydrolysis enzyme (BSH). Ukunyuka kwe-bile acid engabonakaliyo kusebenze indlela ye-FXR-FGF15 emathunjini, ikhusela umsebenzi wokuthintela intestinal, ikhuthaza ukubonakaliswa kwe-ornithine aminotransferase (OAT) kwi-hepatocytes, kwaye ngaloo ndlela ikhuthaza imetabolism ye-ornithine eqokelelweyo kwisibindi kwi-glutamate. Ukubonelela ngezinto eziluhlaza ze-detoxification yesibindi kunye nokunciphisa umonakalo weseli yesibindi.

olu phononongo, abaphandi baqala ukubangela isifo sesibindi esinxilisayo kwimodeli yegundane kwaye bahlalutya imiphumo yefiber yokutya kwisifo sesibindi esinxilisayo kwiimpuku ngokuncedisa zombini i-soluble kunye ne-insoluble fiber.

Iziphumo zafumanisa ukuba i-soluble dietary fibre supplementation iphucule kakhulu isifo sesibindi esinxilisayo kwiimpuku, kubandakanywa nokunciphisa i-steatosis yesibindi kunye nokunciphisa ipesenti kunye nenani elipheleleyo le-neutrophils yesibindi, ngelixa i-fiber yokutya e-insoluble ayinayo impembelelo ebalulekileyo.

Ngenxa yokuba i-fiber yokutya inokuchaphazela kakhulu i-gut microbiota, abaphandi bahlalutya ngakumbi ukuba ukuphuculwa kwesifo sesibindi esinxilisayo kwakubangelwa yi-gut microbiota ngokusebenzisa iindlela zokutshintshwa kwe-microbiota.

Emva kokutshintshwa, kwafunyaniswa ukuba ukutshintshwa kwe-microflora yeempuku ezityiswe i-soluble dietary fiber kunciphisa i-serum alanine aminotransferase (ALT) kunye namanqanaba e-aspartate aminotransferase (AST), ngelixa kunciphisa i-steatosis yesibindi kunye namanqanaba okudumba, ebonisa ukuba i-soluble dietary fiber inokuchaphazela ukuphuhliswa kwe-ALD ngokuhlaziya ukubunjwa kwe-intestinal microflora.

Uphononongo lubonise ukuba i-soluble dietary fiber iphucule i-necrosis yesibindi, i-steatosis yesibindi kunye nokudumba kwimodeli yempuku yesifo sesibindi esinxilisayo, kwaye yanciphisa inqanaba le-ammonia yegazi kunye noxinzelelo lwe-oxidative, igxininisa indima ebalulekileyo ye-soluble dietary fiber ekuthinteleni kunye nonyango lwesifo sesibindi esinxilisayo.

Kubalulekile ukuba uqaphele ukuba abantu abadala bacetyiswa ngokubanzi ukuba badle i-25-30 grams okanye ngaphezulu kwe-fiber yokutya ngosuku, kodwa abaninzi abantu abahlangabezani neengcebiso zokutya. Iinkozo ezipheleleyo, iziqhamo kunye nemifuno ziyimithombo etyebileyo yefiber yokutya kwaye inokubonelela ngezinye izinto ezincinci ezibalulekileyo.

Isishwankathelo, iziphumo zibonisa ukuba ukutya okutyebileyo kwi-fiber yokutya e-soluble kunokuphucula ukulimala kwesibindi okubangelwa utywala kwiimodeli zemouse ngelixa ukhusela ingqibelelo yesithintelo samathumbu. Olu phononongo lunexabiso elithile leklinikhi kunye nokubaluleka kwentlalo.

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