I-Sucralose ayithathi nxaxheba kwi-metabolism emzimbeni womntu kwaye ayifuntshwa ngumzimba womntu. Ngexabiso le-calorific elingu-zero, i-sucralose yeyona nto ilungileyo endaweni yeswekile. Ihlolwe kwaye yaqinisekiswa yi-FDA kwi-1998. Ingasetyenziselwa njenge-sweetener yendalo yonke yokutya, kwaye ayichaphazeli ukuxinwa kwe-glucose egazini. Inokwamkelwa ngabaguli abanesifo sikashukela. Ukongeza, i-sucralose ayisetyenziswa yibhaktheriya ye-caries yamazinyo kwaye inokunciphisa inani le-asidi eveliswa yibhaktheriya yomlomo kunye nokunamathela kweeseli ze-streptococcal kumphezulu wamazinyo, ngokudlala indima ye-anti caries. Uphononongo lwezilwanyana lubonise ukuba i-sucralose ikhuselekile ukuba ingasetyenziswa ixesha elide kwiidosi eziphindwe kalikhulu kunamanqanaba okusetyenziswa kwabantu. Uvavanyo lwexesha elide olwenziwa kumavolontiya angabantu aqhelekileyo lubonise ukuba i-sucralose ayinazo iziphumo ezingenakuguqulwa kwimpilo yabantu. Emva kovavanyo lwesiqinisekiso sokhuseleko lwexesha elide, i-FDA yase-US iqinisekisile ukuba sisongezo sebakala le-GRAS (lokhuseleko).

I-Sucralose isetyenziswe kakhulu kwiindidi zokutya ezingaphezu kwama-400, kubandakanywa iziselo ze-carbonated, iziselo ezinxilisayo, iziqhamo kunye nemifuno enkonkxiweyo, ukutya okufakwe emanzini kunye neesosi, iijam, izinto ezibhakiweyo, i-ayisikrimu, iimveliso zobisi, ii-cereals zakusasa, kunye ne-sweeteners yemihla ngemihla. Iziselo ezineekhalori ezisezantsi zezona ntengiso zinkulu zokwenziwa kweswiti, ezinabathengi abazizigidi ezingama-87 eUnited States kuphela. I-Coca Cola kunye ne-PepsiCo baye baqalisa ngokulandelelana iziselo zekhalori eziphantsi zisebenzisa i-sucralose njenge-sweetener, eya kuba yinto ekugxilwe kuyo kwintengiso yemarike yexesha elizayo. Oku ngokungathandabuzekiyo kuya konyusa kakhulu imfuno ye-sucralose kwimarike.