Kwinkalo yobungcali yezondlo,ivithamin Ekufana ne-maverick "intloko yomkhonto." Uninziivithaminiimikhwa isebenza njenge-coenzyme kwiimpendulo zemichiza, idlala indima encedisayo, kwaye i-vitamin E iyingqayizivele, inamandla ayo anamandla okukhusela impilo yabantu. Vitamin E yeyabantuamafutha-enyibilikayousapho lwevithamini kunye ne-derivative ye-benzodihydropyrane enesakhiwo esifanayo kunye nomsebenzi webhayoloji, ikakhulu kubandakanya i-tocopherol kunye ne-tocotrienol. Iqela ngalinye lihlulwe kwii-subtypes ezine, i-α, β, γ kunye ne-δ, ngokomahluko kwindawo ye-methyl kwindandatho ye-benzopyrane, iyonke yeentlobo ze-8, kwaye ezi isomers zinamandla okulwa ne-antioxidant. I-radicals yamahhala iklasi yeemolekyuli ezingazinzanga kunye ne-reactivity ephezulu kakhulu yeekhemikhali eziveliswa kwinkqubo ye-metabolism yomzimba. Ukukhanya kwe-Ultraviolet, ukungcoliseka kwendalo kunye nezinye izinto zangaphandle zinokubangela ukuveliswa kweeradicals zamahhala, kunye ne-mitochondria yindawo yokuvelisa i-radical yamahhala xa iiseli zenza i-aerobic metabolism ukubonelela amandla. Ukugqithiswa kweeradicals zamahhala kubangela uxinzelelo lwe-oxidative, oluhlasela i-biological macromolecules ezifana ne-lipids, iiprotheni kunye ne-DNA ngaphakathi kweeseli, ezikhokelela kumonakalo we-oxidative. Ngamaxesha anzima, i-vitamin E ixhomekeke kwisakhiwo sayo se-phenolic hydroxyl ukubonelela ii-athomu ze-hydrogen ukuba ziphendule ngee-radicals zamahhala, ukunciphisa i-radicals yamahhala, ukuphazamisa i-oxidative chain reaction, kwaye ngaloo ndlela ikhusela iiseli.

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I-fat-solubility ye-vitamin E yenza ukuba isasazwe ngokukhethekileyo kwiindawo ezityebileyo kwiilipids, ezifana ne-cell membranes kunye ne-lipoproteins. Kwezi ndawo, inqanda kakhulu i-lipid peroxidation. Xa iiradicals zamahhala zihlasela i-polyunsaturated fattyiiasidi, ukuvuselela i-lipid peroxidation chain reaction eyonakalisa i-cell membranes kunye ne-lipoproteins, i-vitamin E inokumisa ukusabela kwizigaba zokuqalisa kunye nokuhanjiswa, ukukhusela i-lipids emathunjini, igazi, izicubu kunye neembrane zeseli. Kwinkqubo ye-cardiovascular system,ivithamin Ekunciphisa ukuveliswa kwe-oxidized low-density lipoprotein ngokusebenzisa i-antioxidant effect, inciphisa umonakalo wayo kwiiseli ze-vascular endothelial, kwaye emva koko inqanda ukwakheka kunye nophuhliso lwe-atherosclerotic plaque. Kwangaxeshanye, ivithamin E inokulawula ukwanda kunye nokufuduka kweeseli ze-vascular smooth muscle ukugcina uxinzelelo oluqhelekileyo kunye nokunwebeka kwemithambo yegazi. Ivithamin E ikwadlala indima ephambili kulawulo lokhuselo lomzimba. Ikhuthaza ukwanda kunye nokuhlukana kweeseli zomzimba ezifana ne-T kunye ne-B lymphocytes, iphucula intsebenziswano phakathi kweeseli, kwaye iphakamisa impendulo yokuzivikela. Ngexesha elifanayo, lithatha inxaxheba kulawulo lwe-immune cell transduction transduction, ichaphazela ukukhuselwa kunye nokubonakaliswa kwe-cytokines, kwaye ilawula ukuphendula komzimba. Imithombo ephambili yendalo ye-vitamin E ibandakanya i-oyile yemifuno, i-nuts, imbewu, kunye nemifuno eluhlaza eluhlaza. Kule mithombo, i-oyile yemifuno yizona zityebi kwi-vitamin E, ubukhulu becala kwi-alpha-tocopherol. Ukongezelela, kukho izongezelelo ze-multivitamin E kwiimarike, kubandakanywa i-softgel, iipilisi ezihlafunwayo kunye neekhilimu, ezifanelekileyo kwiimfuno zamaqela ahlukeneyo abantu. Ngokusekelwe kwireferensi yezondlo zokutya, ukuthathwa okucetyiswayo kwe-vitamin E kubantu abadala yi-15 mg ngosuku (kulinganiswa kwi-alpha-tocopherol elinganayo). Nangona kunjalo, idatha yophando yokwenyani ibonisa ukuba umyinge we-vitamin E esetyenziswa ngabantu abadala ngokutya kwabo kwemihla ngemihla ihlala ingaphantsi kwe-10 mg. Olunye uphando luye lwabonisa ukuba kwi-adjuvant therapy kwizifo ezithile ezifana nokulibazisa ukuguga kunye nokuphucula ukuphazamiseka kwengqondo, ukongeza i-200-800 mg ye-vitamin E imihla ngemihla ingaba nefuthe elithile. Ngokuqhelekileyo, i-vitamin E yomlomo ikhuselekile, kodwa ixesha elide lokutya okuphezulu (ngaphezulu kwe-1,000 mg ngosuku) kunokunyusa ithuba lokuphendula okubi njengomngcipheko wokuphuma kwegazi. Ngoko ke, xa usebenzisa izongezelelo ze-vitamin E, kubalulekile ukulandela iingcebiso zeengcali zokuqinisekisa ukhuseleko kunye nengqiqo yesongezo.