Umhlaza weProstate (i-PC), enye yee-cancer eziqhelekileyo emadodeni, ifana nombulali othuleyo, kunye nezigulane ezininzi zifumana iimpawu ezikhulayo zesifo ezinokuthi ekugqibeleni zikhule zibe ngumhlaza osongela ubomi. Ngelo xesha, umhlaza we-prostate unokuba yinto engathandekiyo kangangokuba zonke iindlela zonyango ezikhoyo aziphenduli kuyo.

Njengoko ilizwi lihamba, unyango luxhomekeke "kumanqaku amathathu amayeza, amanqaku asixhenxe okugcinwa", le "isondlo" ixesha elininzi libhekisela kwi-tonic yokutya. Umhlaza wedlala lobudoda sisifo esiqhubela phambili ixesha elide. Ukuba iindlela zokungenelela ezifanelekileyo, ezifana nendlela yokuphila efanelekileyo kunye nokutya, zingamkelwa kwinqanaba lokuqala lesi sifo, sinokulibazisa ngokufanelekileyo ukuqhubela phambili komhlaza wesifo seprotate kunye nokuphucula ukuxilongwa kwezigulane.

Ngomhla wama-25 ku-Okthobha, ngo-2024, iqela likaNjingalwazi uLloyd Trotman we-Cold Spring Harbour Laboratory epapashwe kwijenali yezemfundo yamazwe ngamazwe iSayensi enesihloko esithi: Unyango lwe-Dietary pro-oxidant yi-precursor ye-vitamin K ijolise kwi-PI 3-kinase umsebenzi we-VPS34 Iphepha loPhando.

Uphononongo lufumanise ukuba isongezelelo se-pro-oxidant, i-menadione (ivithamin K3), inokucothisa ukuqhubeka komhlaza wedlala lobudoda. I-Menadione yi-precursor e-soluble yamanzi ye-vitamin K, edla ngokufumaneka kwimifuno eluhlaza eluhlaza, kwaye umsebenzi wayo we-physiological ikakhulu ukukhuthaza ukuqiniswa kwegazi kunye nokuthatha inxaxheba kwi-metabolism yamathambo.

Izifundo ze-Mechanism zibonise ukuba i-VPS34 iyinjongo ephambili ye-phosphatidylinositol 3-kinase (PI3K), i-menadione inokuthintela umsebenzi we-VPS34, ukunciphisa ukuveliswa kwe-PI3P, kunye nokwandisa uxinzelelo lwe-oxidative olukhokelela ekufeni kweeseli zomhlaza we-prostate. Ngokwahlukileyo koko, iiseli eziqhelekileyo zikhula ngokucothayo kwaye ngenxa yoko zinemithombo eyaneleyo yokumelana nalo monakalo. Ukongeza, iqela lophando libonise ukuba i-menadione nayo inefuthe lonyango kwisifo esibulalayo sofuzo esibizwa ngokuba yi-X-linked myotubulin myopathy (XLMTM).

Ezi ziphumo zibonakalisa indlela elula kodwa esebenzayo yokungenelela kumhlaza kwaye ibe nemiphumo emitsha yonyango lwezinye izifo ezibangelwa yi-dysregulation ye-kinase.

Iqela liphatha iimodeli zegundane ze-RapidCaP kunye ne-pro-oxidant supplement, i-menadione sodium sulfite (MSB), i-compound eyi-mammalian precursor ye-vitamin K. Bafumene ukuba isongezelelo semihla ngemihla se-MSB kumanzi okusela kunokuthintela ukuqhubela phambili komhlaza wesibeletho kwaye uvelise umphumo ongapheliyo wokuthintela.

Ngokubanzi, uphononongo, olupapashwe kwiSayensi, lucebisa ukuba ukongeza izongezo ze-pro-oxidant kwisondlo sokuncedisa i-MSB kunokulibazisa ngokufanelekileyo ukuqhubela phambili kwesifo somhlaza wesifo seprotate. Oku kungenxa yokuba i-MSB inokuthintela umsebenzi we-PI3K kinase VPS34, ukunciphisa ukuveliswa kwe-PI3P, kunye nokwandisa uxinzelelo lwe-oxidative, olukhokelela ekufeni kweeseli zomhlaza we-prostate. Ukongezelela, kwi-X-linked myotubular myopathy (XLMTM), i-MSB inokuthintela umsebenzi we-kinase we-VPS34, ukubuyisela i-PI3P kumanqanaba anokuphucula ukuphuhliswa kwemisipha.