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    Kutheni i-mannitol isebenza kwizifo ze-urinary tract

    2025-03-13

    2. I-Mannose (okanye i-D-Mannose) yiswekile elula, kodwa ngokungafaniyo ne-glucose, i-mannose ayifuntshwa lula ngumzimba emva kokusetyenziswa, kwaye i-90% ye-mannose ikhutshwe ngokuthe ngqo ngomchamo emva kwemizuzu engama-30 ukuya kwe-60 emva kokuyithatha, ngoko ngokungafaniyo ne-glucose, i-mannose ayichaphazeli iswekile yegazi, kodwa igxininiswe kakhulu kumchamo. I-Mannose inokuphazamisa i-glucose metabolism, inqanda ukuchithwa kwamafutha, ilawula i-intestinal flora kwaye ithathe inxaxheba kwi-immune regulation. Ukuqonda okubanzi kwendlela yokwenza i-mannose kunyango lwezifo ezinxulumene nayo isitshixo sokwandisa isicelo sayo seklinikhi.
      Kwiminyaka yakutshanje, kukho izifundo ezininzi malunga ne-mannose. Namhlanje, siza kuxubusha ukuba i-mannose inaso nasiphi na isiphumo kunyango lwe-urinary tract infection. Usulelo lwe-Urinary sisifo esibangelwa usulelo lwebhaktheriya nakweyiphi na izicubu zomzimba kwindlela yokuchama, kubandakanywa nezintso, ureter, isinyi, urethra, njl., kodwa usulelo lwe-urinary tract lulawulwa yi-bladder kunye ne-urethra. Ngenxa yokwahluka ngokwasemzimbeni phakathi kwamadoda nabasetyhini, abasetyhini banethuba eliphezulu losulelo lomgudu womchamo kunamadoda. Uphononongo lubonisa ukuba abasetyhini banethuba elingama-50 ekhulwini lokufumana usulelo lomchamo ngexesha lokuphila kwabo, kwaye phakathi kwesithathu nesiqingatha sabo bosulelekileyo baya kosuleleka kwisithuba esingangonyaka.
      Ukusukela ngeminyaka yoo-1980s, imannose ibisetyenziswa ngoogqirha bezonyango abasebenzayo ukunyanga usulelo lomchamo. Kwiminyaka yakutshanje, kunye nobungqina obuninzi bophando obubonisa iziphumo zonyango kunye nokukhusela kwe-mannose, indima ye-mannose kunyango losulelo lwe-urinary tract iye yatsala ingqalelo yeyeza eliqhelekileyo.
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      Isebenza njani imannose?
      Xa ikhutshwe ngezintso, isinyi, kunye ne-urethra, i-mannose iya kuvala iiseli zezicubu ezidlulayo kunye neebhaktheriya ezizama ukunamathela kwiiseli, zenza iibhaktheriya zingakwazi ukunamathela kwi-bladder kunye neeseli ze-urinary duct, zithintela indlela yosulelo lwebhaktheriya, kunye neebhaktheriya ezingakwazi ukunamathela kwi-urinary tract tissues ziya kulandela umchamo ngaphandle komchamo. Uninzi lwezifo ze-urinary tract zibangelwa uropathogenic Escherichia coli (UPEC). I-UPEC ibophelela kwimannose kumphezulu we-bladder epithelial cells nge-FimH protein kwaye ayihlanjwa lula ngumchamo. Bayilungisa i-mannose ukuze bafumane i-mannoside (M4284). Ukunxulumana kwayo neprotein ye-FimH kumaxesha angama-100,000 aphezulu kune-mannose, kodwa ayihambelani nomphezulu wesinyi kwaye inokukhutshwa nge-E. coli kumchamo.
      Kuphononongo lwamazwe ngamazwe lwe-2016, izigulane ezithatha i-mannose iintsuku ze-13 zafumana ukuncipha okukhulu kweempawu kunye nokuphuculwa okuphawulekayo kumgangatho wobomi babo njengoko kuhlolwe ngamaphepha emibuzo. Ukuthintela ukusuleleka ngokuphindaphindiweyo kwe-urinary tract, abaphandi bahlula izigulane zibe ngamaqela amabini, iqela lokungenelela laqhubeka lithatha i-mannose, iqela lokulawula alinanto. Isiphumo seqela le-mannose, kuphela i-4.5 ekhulwini lokuphindaphinda kwiinyanga ezintandathu, xa kuthelekiswa ne-33,3 yeepesenti yeqela lokulawula. Abaphandi bagqibe kwelokuba imannose inokunceda kunyango lwezifo ezibukhali ze-urinary tract kwaye inokuthintela ngempumelelo ukuphinda usuleleke kwi-urinary tract.