I-Yeast beta-glucan yipolysaccharide esebenzayo ephuma kudonga lweseli ye yeast. Ngo-1941, uGqr. Pillemer wafumanisa into kudonga lweyeast cell eyomeleza amandla omzimba. Ngo-1961 uRiggi wachonga esi sithako sisebenzayo kwi-yeast glycan njenge-beta-glucan [1]. Imithombo eqhelekileyo ye-beta-glucan ikwabandakanya i-oats, i-fungi, i-seaweed, njl., kuba umzimba awukwazi ukwenza okanye ukufihla i-beta-glucan ngokwayo, kufuneka ixhaswe lihlabathi langaphandle.

Ukongeza kwi-β-glucan kunye ne-yeast cell wall, kukho i-mannose enyibilikayo emanzini kunye nenani elincinci le-chitin, i-β-glucan ibalelwa kwi-30% ukuya kwi-60% yobunzima obomileyo bodonga lweseli, kumbindi wangaphakathi wodonga lweseli, yeyobume bepolysaccharide, owona msebenzi uphambili we-physiological kukugcina udonga lweseli, ukugcina i-cell cell. UMisaki et al. ifumene ukuba i-yeast ye-β-glucan iqulunqwe ikakhulu yi-β-1, 3-bond, kwaye iqulethe inxalenye ethile ye-β-1, i-6-bond residues.

Ukusebenza kwe-immunomodulatory ye-yeast beta-glucan kuxhomekeke ekujoliseni kwayo okuchanekileyo, ukukwazi ukubopha kwii-receptors ezithile kumphezulu weeseli zomzimba, ngelixa uphucula umsebenzi we-phagocytosis we-macrophages. Le nkqubo ilungisa ngokukhawuleza ukusabela komzimba kunye nokugcina ibhalansi efanelekileyo ye-immune system.

I-Beta-glucan yenza ngokuyinhloko ngokubophelela kwiintlobo ezintathu ze-beta-glucan receptor [4]: ??(1) i-Dectin-1 receptor; (2) CR3; (3) Ezinye ii-receptors, kuquka i-scavenger receptor kunye neLacCer. Xa imvubelo i-β-glucan ingena emzimbeni womntu kwaye ibophe kwi-receptor, iya kwandisa i-phosphorylation ye-intracellular immune receptor tyrosine motif (ITAM) kunye ne-Syk, kwaye isebenze indlela ye-PI3K / Akt, ekugqibeleni ikhokelela kwi-phagocytosis, ukufa kwe-microbial kunye nokukhululwa kwe-cytokine, ukwenzela ukuba kuthintelwe ukukhupha iiseli zangaphandle zentsholongwane kunye nokukhusela ngaphandle kweeseli zangaphandle. Kwaye ke ufumana umphumo wokugonyeka.

Izibonelelo zempilo yolusu ze-beta-glucan zibonakaliswa ikakhulu kule miba ilandelayo [6]:

I-1) Umthamo we-Antioxidant: I-β-glucan inezakhiwo ze-antioxidant, ezinokuthintela ukuveliswa kwe-superoxides kunye nezinye iintlobo ze-oksijeni ezisebenzayo (ROS) kunye nokunciphisa umonakalo woxinzelelo lwe-oxidative kwesikhumba.

I-2) Impembelelo yokuthambisa: Ngobunzima bayo obuphezulu be-molecular, i-β-glucan inamandla okubopha amanzi, anokuthi afake ngokufanelekileyo iamolekyu zamanzi kumphezulu weeseli zesikhumba, ukuthintela ukukhuphuka kwamanzi, kunye nokunciphisa ukulahlekelwa kwamanzi nge-epidermis (TEWL). Ukongeza, yenza ifilimu ekhuselayo ebusweni bolusu, inceda ukugcina umswakama kunye nokuthamba kwesikhumba.

3) Ukulungiswa kwesikhumba kunye namandla okuphilisa: Seo et al. ufumanise ukuba imithombo eyahlukeneyo ye-beta-glucan inokukhuthaza ukufuduka kweekeratinocytes zabantu (HaCaT) kunye ne-fibroblasts yesikhumba somntu (HDFa), kwaye ikhawulezise ukuvalwa kwamanxeba kunye nokuphinda kufakwe i-epithelialization kwiimodeli zemouse [7]. Ukongeza, iipropathi ezichasayo kunye ne-anti-irritant ze-beta-glucan zinceda ukukhulula ukuvuvukala kunye nokubomvu kunye nokuthomalalisa ulusu olucaphukileyo. Uphononongo kwiJournal of Therapeutic Dermatology lubonise ukuba i-beta-glucan sisixhobo esisebenzayo kunyango lwe-atopic dermatitis ethambileyo (eczema) [8].

I-4) Iziphumo zokulwa nokuguga: I-Beta-glucan inceda ukunciphisa iimpawu zokuguga kwesikhumba, njengemibimbi kunye nokugubha. Ikhuthaza ukuhlanganiswa kwe-collagen kunye nezinye izinto ze-extracellular matrix (ECM) zesikhumba, ukwandisa ubukhulu kunye nokuqina kolusu.

Ukongeza, i-beta-glucan nayo inendima yokulawula i-intestinal flora, ukunciphisa i-cholesterol, i-anti-fatigue, impilo yethambo kunye nokunye.

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