1.1 ??? ??? ???????? ???????????? ??? ??????????????????? ??????????

???? ?????????? ??? ???? ????????? ???????? ???? ???????? ??????????????? ??? ???????? ??? 1956, ??? ??? ?????????? ??? ???????????? ??????? ??? ?? ??????? ??? ???????????? ????????????:

• 1980?? ?????:???? ?????? ??? ?? ??? ???????? ????????? ?????? ???? ?? ?????

• 2010??:??? ??? ??????? ?? ?? ??? ?????????? ????????? ???? ???????? (PET-CT ??? ??????? ? 23% ???????????? ??? ????????? ??? ???? ?????)

• ??? 2024,?? NIH ??? ?? ??????????? ????? ??? ?? ??????????? ??? ? ????? ???????????? ???????? ??? "??????????????? ???????"

1.2 ?????????????? ?????? ??? ??? ????????? ?????

???? ?? ????? ??? Evaluate Pharma:

??????? ???????????? ???? ????????? 4.7 ?????? ?????????? ????? ??? 2024 (CAGR 12.3%)

?? ??????? ?????? ??? ?????? ????????? ??? ???? ??? ??????? ??? 400% ??? ???? ????

???????????? ????? ?????????????? ???????? ??:

???????????? ?????? (MMSE ?????? ??????????? ??? 2.1 ??????)

???????????? ??? ????? (GOS ?????????????? ????? ???????? ??? 1.5 ??????)

?????? ?????: ???????-????? ?????? ??? ?? ???????? ??? ?????

?

2.1 ????? ?????? ??????????

??? ???????? ???????? ??????: ??????????????????? ?????? ??????? ?????????? ????????? ???????????? ????? I: ?????????????? ???????????? ??????????? ????????????????? ??????????? ????? IIA: ?????? ??????? ????????? ?????????? ????????? ????????????????? ????????? (????????? ??????????? ???? 18%) ????? IIB

?

2.2 ??????? ???????? ???????? ?????????

? ?????? ??? ??2024 ???? ??? ????? ??????????? ?????? ??? ??? ???-??? ????????????? ??????:

??????????????? ??????????? ??? ??1000 ?? ??? 6 ??? ???? ?? ??????????? ?????????? ??? ????????? ??? ??? ??? ??? ????????? ???????? ??? ??? 7.2 ??????????.3

????, ?? ??? ???? ?????? ???? ????????? ???????????? ????? ???? ?? ????????????? ??? ???????????? 72 ??? (p=0.34).

?????? ????: ??? ?????? ??? ?????????????

?

3.1 ????????? ????? ?????????

??????? NICE ?????????: ??? ???? ?? ?? ??????????? ???????? ????? ???? ????? ?? ????? ?????????? ??????????? ?????????? (?????-???????????? ????????? ￡45,000/QALY)

??????? ???????????? **2025 ?????-????????: ???? ????????????? ?????????? ??? ?????????? ??? ??? ?????? ??? ?????? ???????????? ???????????? (p=0.21)

3.2 ?????? ??? ?????????? ???????????

?? ????????? ?????????? ???????? ?????????????'? 2024 ???????:

?????? ?????????????? ???? ???????????? ?? ??????????? (?????????? "??????????? ???????" ??? "??????? ????????")

????? ???? ?? ???????? ??-?????? ???????????? ??????? ??? ??? ????????? ???????? ??? 32% ??? ???????? ??????????????? ??? ????????? ??? 70% ??? ??? ??????????? ????.

?????? ???: ??????? ??? ??????????? ?????????

?

4.1 ???? ??????? ???????? ??????

????-??????? ??????? ????????????? ????????? ???????????? ???????????? (???????? ??? ??????? ????????????? ??????????, CN202410123456.7)

???????????? ?????????-??????? ???????????? (???? ????????????? ??? ?????? ????????????? ????????????? ??? ???? ????? ??????? ?? ??????????? ????????????? ??? ???????????????????)

?

4.2 ??????? ???? ???????????????????? ??????????

Bgi'? ?????????? ???????? ??? ??????? ???:

??? ????????????????? ???? ??? CDP-????????????????????? ???????????????? ????????????? (????? ????? ???? 31% ???? ??? ??????????? ?????????????) ??? ????????? ??? 47%

?????? ???? ????-????? ???? ??? ????????

?

5.1 ?????????? ?????

? ?????? ??? ? ???????? ?????? ??? ????????: ??? ?????????? ??????????, ??? ??? ?? ????????? ???? ????? ??????? ????????? ??? ? 62 ?????? ??????? ??? ????????? ???????? ??????? ??? 32% ?? 89%

5.2 ??????-??????? ??? ??? ??????????? ??????

"???????? ?? ??? ? ???? ??? ?? ???????, ?? ????????? ???????? ??? ??300 ???? ??? ??? ???????? ???? ??????????????????" - ?? ?????????? ?????? ??? ???? ??, ? ????????? ??? ?????????.