??? 1976, ???? ?????????? ????? ?????? ??????? ????????????? ????????????? ??? ????????, ??? ????????????? ??????????? ?? ??????????? ??? ???? ???? ????????, ???????????, ????? ??? ??????? ?? ??????? ???????? ??? ?? ???? ??? ???????????, ?????? ??????????? ??? ???? ????? ???, ????? ???? ???????, ??????? ????? ???? ??? ????????? ??? ???????????. ??? ?? 1980 ?, ??????????? ???????????? ???? ?????????? ????, ?????????????? ?????????????????? ??????? ??? ?????? ???????, ??????????????? ????? ?????????? ??? ??????? ??? ??????????? ??????, ??? ??? 1991, ??????????? ??? ?????? ?????? ????????? ??? ???????? ????? ???? ??? ?? ????????? ?????????. ?? ??????????? ?????? ??? ??? ????? ????????????????? (FDA) ????????? ??????????? ??? ?? ???????? ?????????? ????? ????????? ??? ???????????, ??? ?? ????????? ??? ??????????? ????????????, ?? ??????????? ???? ??? ??????????? ????? ???????????? ??????, ???? ?? ??? ????????????? ??? ?? ?????, ??? ?? ??? ??????? ?????? ??? ????? ?????? ??? ???????????. ??? ?? ????? ?????, ?? ?????????????? ?????? ??? ??????????? ????? ???? ???????????, ????? ??? E- ??????????? ??????, ??????????????? ????, ????????????? ????????? ??? ????? ????. ?????? ???, ??????????? ??????? ???? ?? ????? ???????? ???? ???????????? ?????? ???????????, ?? ???? ??? ??????????? ??? ???? ??????? ??? ???????????? ?????????.

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??? 2015, Lu Xialian (??????? ????????????????? ??????????? ??? ???????????) ??? ?????? ??? ??Sun Yat-sen ????????????? ?????? TG-DSC-FTIR ???????????? ?? ????????? ?? ??????? ????????????????? ??????????? ??? ???????????, ??? ?? ?????????? ??????? ??? ??????????? ?????? ???????? ?? ??????? ??? 120 ℃, ??????????? HCl, H2O ??? CO2. ???? ??? ???????? ??? ??????????? ??? ????????? ??? ????? ?????, ??????????? ???? ???????? ?? ???????. ?? ????????? ???????? ?????? ???? ????? ????????????????? ??? ??????? ??? ??????? ??? ?????????????? ?????, ????? ??? ??? ?????? ???????????? ??? ????? ?????, ??? ?? ????? ???? ?????????? ??? ??????????? ??? ???? ??????????? ?????? ???????????? ?? ??? ????? ??? ?????? ???? ???????????? ?????? ?????? ?????? 200 ℃. ???? ?? ??? ???????? ???? ???????????? ?????? ??????????? (> 200 ° C), E- ??????????? ?????? ???? ??? ?? ??????? ???????????? ????????? ??? ???????????? ????????? ??????. ??? 2019, Rachel El-Hage (??????? ???????? ?????????? ??? ??????????? ???????? ?? ??????????? ??????????? ???????? ?? ??. ???????? GC-MS ?? ?????? ?????????? ??????? ??? E- ??????????? ???????? ??? ??????????? ????????, ??? ???????? ????? ????????????????????? ???????? ??? ?? ?????????? ???????, ??? ?? ???????? ??? ????????????????????? ???????????????? ??? ?? ????? ????. (???????????-???????? ????????????? ??? ??????????? ??????????? ???????? ?????? ?????????) ?? ?? ???????????? 1H NMR ????????????????, ???? ????????????????? ??? ???? ????????????????? ????????? ??? ????? ?????????????? ??? ????? ?????????????? ????????? ???????? ??? ??????????? ? ?? ??????????? ??? ??????????????? ?????? ???????????????????? ??? ?????????????????? ??? ??????????? ??? ?? ???????????? ??? ?? ????????????. ??????????.

??? 2024, E- ??????????? ?????????? ?????????? Yan (?? ?????? ??? ??????????? ??? ????????? ???? ?? ?????????? ??? ?????? ???????? ??? ??????????? ??????????? ??? ??????????? ????? ????????? ?????? ????? ???????????, ????????? ??? ???????????, ???? ?? ??????? ??? ????? ??????? ????? E- ??????????? ??? ????? ???????? ???? ??? ????????. ?????? ???????? ???? ??? ???????? ????? ????????? ?? ??????????? ??? E- ???????????

??? ?????, ??????????? ??? ???????? ??????? ??? ????????? ??? ??? ??????? ?????? ?????. ??? E- ??????????? ??????, ??????????? ????? ??? ???? ?????????? ????? ??? ????????????? ??? ???????, ????????????? ??? ????? ?? ??????????, ?? ????????? ?????????? ????? ????? ??? ???? ?????????????????, ????? ????? ????????? ?? ????? ?? ???? ????? ??????????? ??? ?? ??????, ??? ?? ???? ??????????? ??? ?? ??????. ??? ?????, ?? ????? ???? ???? ??????? ????? ???????, ??? ?? ??? ???? ?????? ?? ???????? ??????????? ????????????? ?????????????? ??? ???????????? ???????????.