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???????????? ??? ?????? ??? ?? ??????? ??????? ??????? ??? ??? ????? ??? ??? ?? ?????????? ??? ?? ?????????????????? 5-????????????????????? (5-??, ???? ?????? ??? ????????????) ??? ??? ?????. ? ????? ????? ??? ??????? ????? ??????? ??? ???????????? ??????????????? ?????????? ????? ??? ??????? ?? ?? ?????????????? ??? ???????? ??????, ????? ??? ?????????, ???????, ?????????????? ??? ????? ????. ??? ??? ???????? ????, ???????????? ??? ????? ???????????? 5-?? ????? ???? ?????????? ??? ?? ???????? ??? ???????? ??? ??????? ?????. ?????, ?????? ??????? ???? ??????, ???????????? ??????????????? ?????? ??? ??? ???????? ???? ?? ??????????? ????-?????? ??? ??????? ??? ?? ?????? ??? ?????, ?? ?????????? ?????? ?? ????? ??? ????????? ??????????????.

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??????, ?? ?????????? ?????? ???? ?? ??????????? ?? ??????? ????-?????? ??????????? ??? ?????? (CMS). ??? ??????????? ?? ???? ?? ?? ?????????????? ??? ??????? ????????????????? ????????, ????? ??? ????????????? ????, ??????? ?????? ??? ????? ??????? ?????, ????? 21 ????????????? ??? ?? ???????? ???????????, ???????? ???????? ??? ??????? ????. ?? ?????????? ??????? ??? ???? 21 ??? ??? ??????? ????, ?? ???? ??????????? ?????????? ??????? ??? ?????????-??? ??????. ??? ?? ?????? ???? ???????????? (OFT), ?? ???? ??? CMS ?????? ???? ??????? ??? ?? ????? ????? ??? ?????? ???? ??? ???????? ?????????, ????? ???????? ??? ????? ??????? ????? ??? ????????. ??? ?? ?? ????????? ???????????? (TST), ?? ???????? ???? ??? ???? ??? ?? CMS ?????? ??? ???????? ?????????, ????????????? ?? ???????? ????? ??? ??????????????. ??? ??? ???????? ????, ?? ????????? ?????? ??? ???? ??? ?? CMS ?????? ???????? ????????, ????? ?? ????? ??????? ????????, ????????????? ??? ????? ???????? ??? ??????????????? ????? ????????????.

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????? ???????????? ????? ???? ????? ????? ?? ????-????? ????????, ???? ???????????? 5-HT ?????? ?? ??????? ????? ??? ?? ?????????????????? ??? ?? ????? ??????? ?????? ??? ??? ?????????? ??? ????????????? ???? ????????????????? ??????????? ????? ??? ???????, ????????? ??? ???. ?? ?????????? ???????? ?????????? ?????????? ??? ?? ???????? ??? ?????? ???????????????? ??? 5-?? ??????????? ?????????? ??? ???????? ???????? ??? ?? ????????????????. ?? ?????????? ????? ??????? ??? ??????? ???? ???????? ???????????????? ?? ???????? ??? ???????? ????????????? ???????????????? ????? ??? AgRP ??? OX1R, ???? ????????????????? ?? ???????? ??? ???????? ??????????? ????? ????? ??? LEPR, MC4R ??? 5-HT1B. ???? ?????????? ??? ?? ??????? ??? ?????????????-5-?? ????????? ??? ???? ?? ??????????? ?????? ?????? ???? ????????? ?? ???????????????? ??????? ??????.

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?????, ????? ??????????????????? ??? ???????????? ?????????? ??????? ????-?????? ??????? ??? ??? ?????? ????????????????? ????? ?????? ??? ???????????? (100 ?? / ?? ??? 300 ?? / ??) ????? ????????????? ?? ??? ???? ???? ?????? ????????? ????? 21 ???. ?? ?????????? ??????? ??? ???? 21 ??? ??? ?????????????? ??? ?? ???? ????? ??? ?????????????? (300 ?? / ??), ?? ??????? ??? ?????????-??? ?????? ??? ???? ??? ?????? ???? ???????????? ??? ?? ???????????? ???????????? ??? ???????? ?????????, ??? ??????????? ???????? ????????? ?????? ??? ????? ??????? ????? ?????????. ???????? ??????? ????? ??????? ??? ???????????? ?????????????? ??? ???? ????? ????? ???????? ?? ??????-???????? ??? ???????? ????????????? ????? ????? ??? AgRP ??? OX1R ??? ???????????????? ?????? ???? ??????? ????, ???? ?????????? ?? ???????? ??? ???????? ??????????? ????? ????? ??? LEPR, MC4R, 5-HT1B ??? 5-HT2C. ?? ??? ???? ?? ??????? ??? ????? ?? ??????? ????? ??? ?????????????? (100 ?? / ??) ?????? ??? ???? ??????? ?????????? ????????????? ??? ????????? ????????????, ?? ??? ?????? ?? ????? ??? ?????????? ??? ???????????????? ???????? ???????????? ????? ???????? ???? ?? ??????????? ?????.

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?? ?????????? ???? ?????? ?? ???? ???????????????? ??????? ??? ????? GT1-7 ?? ???????? ?????????? ?? ???????????? ???????? ??? 5-HT ???? ???????? ???????????? ????????????????. ??? ???????? GT1-7 ???? ??? 10μ? ??? ????????????????? (CORT) ????? 24 ??? ?? ???????? ??????? ???? ??????. ?? ?????????? ????? ??????? ??? ??? ???????? ??? ???????? ????????????? ????? ????? ??? AgRP ??? OX1R ??? ???????? ??????-????????????? ???? CORT ????????????, ???? ??? ???????? ??? ???????? ??????????? ????? ????? ??? MC4R, 5-HT1B ??? 5-HT2C ??? ???????-?????????????. ???? ?????????????? ??? 0.1μM 5-HT ????? 2 ???, ?? ??????????? ???????? ??? CORT-?????? ?????? ??? ?????? ????? ??? ???? ???????? ????????, ??? ??? ???????? ??? MC4R, 5-HT1B ??? 5-HT2C ??? ???? ??????. ???? ???? ???? ????????? ?? ?????? ???????????? ???????? ??? 5-HT ???? ???????????????? ???????.

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????? ??? ???????????? ???? 5-HT ??????????? ????????? ??? ???????????????? ??? ??????? ???? ????: ????? ???????????? ??? 5-HT ??????? ????? ???????? ???????? ???? ???????????? ??????????????????? (??

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??????? ???? ?? ?????????, ?? ?????????? ?????????? ?????? ????????? ????????????????? ?? ????? ?????? ?????? ????? ??? ????. ?????? ??? ????, ?? ??????? ??????? ??? ?????????????? ????? ???? ??? ?? ?????? ?????, ????? ??? ????, ???, ??????, bananas, ????, ???"? ?, ????? ?????? ??????????? ?? ????? ??? ???????????? ??? ??? ???, ?????? ?? ?????? ??? 5-??????????????????????, ?????? ??????????? ?? ??????????? ????? ??? ??????????? ???? ???. ?????, ?? ???? ???? ????????? ??? ???????????? ??? ????????? ??? ???? 100% ????????? ??? ??????????. ??? ??? ???????? ????, ?????-?????? ????? ????? ??????????????????? ??? ???????????? (????? ??? ??? ??? 500 ?? / ??) ??? ????????? ??? ??????. ???????, ??? ?? ?????? ????? ?????, ????? ???????????? ??????? ????? ????, ???? ??? ????? ?????? ???? ??? ???????????? ????????.

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