??? ??????? ????????? ??? ???????? ?? ???????? ??? ????? ????? ????? ??? ????
????????? ? 3, ???? ?????? ??? ???????, ??? ?? ???????-??????????? ????????? ????? ?????????? ?? ?????????????? ??? ??????? ????????????????? ??????????? ??? ??? ???. ??? ??????? ????? ??????? ??? ????????? ? 3 ??????????????? ??? ??? ??? ? ??????? ??????????????? ????????, ?????????? ?? ??????????????? ??? ???? ????, ??? ???? ??? ?? ????? ???????????????? ????????.
???-?????????????? ????? ????? ????? (NAFLD), ??? ?? ?????? ????????? ??? ??????? ????? ????? ???? ??? ???????, ?? ????? ??? ??? 150 ??????? ????????? ??? ???????, ??? ????? 10-20% ???? ???????? ??????????? ??? ???-?????????????? ??????????????????? (NASH), ??? ?????? ???????????? ???? ?????????? ??? ????? ??? ??????, ???? ??????? ???? ?????????. NASH ???????????? ?????????? ??? ??? ?? ????? ???????? ??? ????????????? ????? ????? ?????? ????? ??? ?????????? ??? ????? ????.
??????, ???????????? ??? ??? ???? ??? ????????? ?????? ??? Sun Yat-sen ????????????? ??????????? ?? ???????? ??? ??? ???????? JAMA Network Open ?????????? "???????? ??????? ?????? ??? ??????????? ?????? ?????? ??? ???-??????????????. ????? ????? ????????" ???????? ????????.
?? ?????? ??????? ??? ??????????????????? ??? ????????? ? 3, ????? ?? ???????? ??? ?? ???????? ??? ????-????? ???? ??? ????????? ??? ???-?????????????? ????? ????? ?????, ??? ?????? ?????????? ??? ?? 30% ???????? ??? ?? ???????? ??? ????-????? ???? ??? ???????????????? ??? ?? ?????? ?????? (≥26.7mg / ????) ????????? ??? ???????????????? ??? ?? ???????? ?????? (≤18.4mg / ????).
??? ??? ??????, ?? ?????????? ?????????? ?? ??????????????? ?????? ????????? ????????? ? 3 ?????? ??? ?? ???????? ??? ????-????? ???? ??? ????????? ??? ???-?????????????? ????? ????? ????? ???? ?????????? ????????? ????????? ? 3 ?????? ??? ?? ?????????? ?????? ??? ????????? ??????? ???????? (NHANES) ?????????? ??? 4,315 NAFLD ????????? ??? ?? ??????????? ????? ??? 53 ????.
??????????????? ????? ??????? ??? ????? ??????? ?????? ???? ????????? ? 3 ??????: ??????? ?????? ?????? (≤18.4?? / ????), ???? ?????? ?????? (18.5-26.6?? / ????) ??? ???? ?????? ?????? (≥26.7?? / ????).
?????? ?? ??????????? ????????-?????? ???? ??? 8.8 ????, ?? ????? ??? 566 ???? ????? ?????????, 197 ??? ????? ????? ????????????? ?? ????????????????????? ?????.
?? ?????????? ??????? ??? ???????????????? ??? ?? ?????? ?????? ????? ?? 30 ????????? ????????? ???????? ??? ????-????? ???? ????????? ??? ???????????????? ??? ?? ???????? ??????.
??? ?????, ???????????????? ??? ?? ?????? ?????? ??? ?? 35 ????????? ???????? ??? ????????????????????? ???? ????????, ????? ???? ??? ???? ?????????? ??????????.
???????? ?????????? ??????? ?? ????????? ???????????? ?????? ????????? ? 3 ?????? ??? ?? ???????? ??? ?????????? ??? ????-????? ????, ??? ?? ??????? ???????? ??? ??????????? ??? ???-?????????? ????????? ????????? ??? ???? ??? ??????????.
???? ?? ??????????, ??????? ??? ?????? ??? ?? ??????????? ??? NAD ?????? ??? ??? ??????? ?? ??????? ??? ????? ??? ?????????? ??? ???????????? ??? ????? ?????. ???????????? ?????????????? ??????? ????? ???? ??????? ??? ??????? ????? ??????????? ????? ????? ??? ???????? ????? ??? ???????. ??? ????????????? ???????, ??????? ??? ??????? ?? ???????? ??? ???????? ????? ??????????? ??? ??????????, ??? ?????????? ?????????. ?? ????? ????? ???????? ???? ???????? ????????????? ????, ??????????? ??????????????? ?????????????????? 2 ??? NADPH ?????????? ????????, ??? ?????? ?????? ????????????.
?? ??? ???? ?? ????????? ??? ??? ????????? 2023, ???????????? ??? ??? ???? ??? ????????? ?????? ??? Sun Yat-sen ????????????? ??????????? ?? ???????? ??? ??? ???????? ????????? ?????????? "?????????? ?????? ????????? ??????? ?????? ??? ???????????????? ????? ????? ????????: NHANES 2003-2018" ???????? ????????.
?? ?????? ??????? ??? ????????? ? 3 ??????????????????? ??? ???????? ??? ?? ????????? ???????? ??? ???-?????????????? ????? ????? ?????, ??? ?? ??? ?? ?????? ??????? ?????? (≥29.2mg / ????) ??? ?? 31% ????????? ???????? ??? ???-?????????????? ????? ????? ????? ????????? ??? ???? ??? ?? ???????? ??????? ?????? (≤16.3mg / ????).
????????, ?? ?????????? ??????????? ??? ????????? ? 3 ??????????????????? ??? ?????????? ??? ?? ????????? ???????? ??? ???-?????????????? ????? ????? ????? ??? ?? ?????? ???????? ??? ????-????? ???? ??? ????????? ??? ???-?????????????? ????? ????? ?????. ???????? ???????? ??? ???? ?? ?????????? ?? ?????????? ????? ??? ??????????? ? 3 ?? ???????? ?? ???????? ??? ????-????? ???? ??? ????????? ??? NAFLD.