??????????? (???????? 5-??????????? ????????, CDP-????????) ??? ??????? ????? ?? ??????????? ??? ???????????????? ????? ??? ????????????????????. ?? ??????????? ????? ??? ????????? ??? ???????????? ????? ????????? ??? ??? ??? [1]. ??????????? ??? ?? ??? ???????????? ?????????? ??? ??????? ????????, ????? ????? ????-????, ????? ?? ??? ?? ????? ???????? ????? ??? ??????????? ?????? ??? ??? ?????. ?? ???????? ????????, ????????? ????????? ?? ???? ?? "???????????" ???? ?? ??? ?????? ??? ?? ???????????? ??? "CDP-????????" ???? ?? ??? ?????? ??? ??? ??? [2]. ?????? ???????????, ?? ??????? ????? ????????????: ???????? ??? ????????. ???? ??? ??????? ?? ????-????? ????????, ??????? ??? ??? ????? ???? ??? ?? ????? ??????????? ??? ?????? ?????????????? [3]. ???????? ???? ??????????????? ??? ?????? ??????????????????? ?? ?????? ?? ??????? ?????? ???????? ??????. ??? ??? ????????? ??????????? ??? ???? ?????? ????????? ????????????. ???????, ??????????? ??? ????? ??? ??????? ??? ?????????? ????? ????? ??? ??????? ???????? [4,5,3].

??? ?? ??????

??????????? ???????? ?? ??????????? ??? ????????????????????? ??? ??? ???? ??????. ??? ???????? ?? ???????????????, ?? ???? ??????????????? ??? ??????????? ??? ??? ????? [4,6]. ?? ????? ?????????? ????? ???? ????? ??? ????????? ??????????????? ?? ??????????? ??? ??????? [4,5,2]. ??????? ??????? ??? CDP ???????? ??????? ???????????????????? ??? ?????????????, ????? ????? ?? ???????????? ????? ????????? ?????? ??????. ??????????? ???? ???????? ?? ?????????????? ?????? ??????????????? ??2 ??? ????????? ?? ?????? ???????????????? ????????????? [7,8]. ??? ?????, ??????????? ??????????? ???? ??????????? ??????????????????? ??? ???????????? ?? ??????? ?????? ??? ????????????? ??? ?????-???????????? ?????? [9,10,1].

????????? ????

??? ??? ?????? ??????????? ???? ???????? ??? ????????. ??? ?????? ???? ?? ??????????? ??????????? ??????? ???? ????????? ??? ?? ???????? ????? ????????? ?????? ????? ??????? ?????. ????????-????? ???? ???????????? [11,12] : ??????? ????? (?????) ???? ????? ??? ????? ?????? ???????? ??? ?? ???? ??????????? ????? ???????????????? ??? ????? (???????? ??????? ?????); ?? ??? ???? ???????? ??? ??????????? [13,14]. ??????????? ???????? (?????????, ???????????) ????? ?? ????? ??????????? ???? ??? ???? ????????, ??? ???????? ??: ???????? ????-???? ???????????????????? ????????

?? ?????? ??????? ??? ??????????? ??? ???? ??????

1) ??????????? ????????????

?????-???????????? ?????????? ??????????? ?????????? ?????????? ???? ?? ??????????? ??? ????? ???? ?? ??????? ???? ?????? ?? ??? ????? ????? ????? ?????? ?????. ? ???????? ??? ??14 ?????? ??????? ??????? ??? CDP-???????? ????? ??????????? ?????? ??? ?????? ??? ????????? ??? ???? ?? ????? ?????????? ???????????, ?????????????? ???? ??? ????? ????? ?????????????? [9]. ??????? ???? ????? ??? ??? ??? 2,800 ????? ?????????, ???? ????????? ??????????? ????????????, ??????? ?????????? ??????????? ??? 21% ??? ????????? ??? ??????? ????????? ??? 45% ??? ?????????. ??? ?????? ???? ??????????? ??????????, ????? ??? ???? ????? ?? ?????????? ??? ?? ???? ??? ????? [18]. ??????????? (1000 ?? ????? 9 ?????) ??? ?????? ????????? ??? 350 ?????? ????????? ??? ???? ?????????? ??????????? ?????? ?? ??? ?????? ?? [19] : ????????? ?? ????? ????????? ?? ??????????? ??????????????? ??? ??????????? ??????? ?? ?????????? ????????????? ?????? ??? ???? ??????? ??? 210 ????????? ??? ????????? ??? ????? ????? ??????? ??????????????, ??????? ???????? ??????????????, ??? ??????? ????? ??????? ??????????????. ?? ????? ?? ????? ??? ????????????? (2000mg), ?? ????? ?? ???????? [20,21,22]. ???? ?????? ???? ??????????? ?? ??????????? ????????, ??????????? ?????? ??? ?????????? ?????????? ???????????. ??? ? ??? ????? ??????????? ??? ?? ????? ????? ????? ????? ??? ?? ??????? ... ??? ????? ?????? ??????? ??? 135 ?????? ???????, ??????????? (250-500 ??) ????????? ?????????????? ??? ???????? ??????? [23,24]. ? ??????? ??? ?????? ??? CDP ???????? (250 ??) ????????? ?????????? ??????????? ??? ?????? ??????? ???? ??? 60 ????????????. ?????? ??? ?? ???????? ?????????? ??? ?? ??? ????? ????????????? ?? ?? ?????????? [25]. ??? 24 ?????? ???????, ????? ?????? ??? ??????????? (500 ????? 1000mg) ????????? ???????? ?????????? ???????? - ??????????? ????????, ?????? ??? ??????? ??????, ???????????? ??????? - ????? ????? ??? ???? ??? ?????? ?????????? ???????? [26]. ??? ??? ???????? ??????, ???????? ????? ???? ???????? ???? ??????????? ???????????? ??? ????? ?? ???? ??????? ?????????? ???????? ??? ???? ????????????. [26] ?????????? ?????? ??????? ?????????? ????????. ??? ?? ?????? ??? 19 ??????? ???????????? ?????????, ??????????? (2,000 ?? ???? ???? ????? 8 ??????) ?????? ??????????? ??????????? ??? ????????? ?????????? ???????????. ???? ???????????????? ??????? ?? ????????? ?????????, ??? ?? ?????????? ??????????? ??? ?? ????? ??? ??????????? ??? ????? ???? ??? ??? ??? ??????? [27,28]. ???? ????????????? ????????, ??????????? ????? ?????????? ?????????????? ??? ???????? ???????, ???????? ??? ?????? ??? ????? ?????????? ??????????.

2) ??????? ?????????????????

??????? ?????? ?? ???? ??????? ?? ?? ????????? ????? ????? ????? ????? ??????? ??? ????????? ?????? ????? ??????. ??????????? ??? ?????? ???? ?????????????? ????? ????????? ??? ???????? ???? ????????? ??????????? [29,30]. ???? ?? ?????-?????????? ??? ??? ?????? ??????? (??? ??? 1,300 ?????????), ??????? 2000mg ??? ??????????? ?? 24 ??? ???? ?? ???? ???????? ?? ?????? ??? ?? ??? ??????? ??? 38% [10]. ????? ??? ??? ??? 4,000 ???????????? ??? ???? ??????? ??? ??????????? ????????? ????????? ??? AIDS ???????; ????? ?????? (2000-4000mg) ????? ??? ????????. ?? ??? ???? ??????????? ????????? ??? ??? ??????, ????? ???? ??????????? ????????????? ??? ???? ???? [31]. ????? ??????? ??? ??? ??? 3,000 ????????? ??????? ???? ????????? ??? ??? CDP-???????? ????? ?????? ???? [32,33]. ?????-???????? ????? ?????? ??? ?????? ????? ????? ?????? ????. ????? ????????? ??????? ??????? ??? ??????????? ??? ??????? ???? ??????? ????? ????? ????????? ????? ????? ???? ???????? ????? ?????? ???????????? [34,35]. ???? ??????????????? ??? ????????????? ??? ??????????? ???? ???????, ????? ???????? ??? ???????. ?????-???????? ????? ?????? ??? ?????? ????? ????? ?????? ????.

3) ?????? ?????????

??? ???????????? ??????? ??? ??? ????? ??? ???????? ????, ??????????? ??? ????? ?? ????? ????????? ???????? ???? ?? ??????? ?????. ?? ??? ???????? ?????? ?? ???????? ??????? ??? ????? ?????? ???? ?????? ????? ??? [1] : ??????? ????????????? ??????????? ????????????? ??????????? ???????? ???? ???? ??? ?????? ????? ????? ?????? ?? ??????? ????? ??? ???? ?? ???????????, ??? ?????? ?? ????? ????????? [36]. ??? ????? ?????? ??????? ??? 80 ??????????? ?????????, ?????-?????? ???? ??????????? ??????? ????? ??????, ????????? ?????? ??? ?????? ????? ???????????? [37,38]. Citicoline ???? ?????? ??????? ?? ????? ?????????? ??? ????? ?????? ?????? ??????? (68 ?????????) [39,40]. ?????????????, ????? "???? ????," ?????? ???? ?? ????? ??? ????? ???? ??? ???????? ??????. ?? ????? ???????? ????? ?????? ??? ???? ????. [41] ??? ???? ?????? ??????? ??? 190 ??????, ???? ??????????? ????????? ???????? ????????????? ???????????? (???? ?????) [42,43,44]. ??????????? ??? CDP ???????? (1000mg ??????) ??????? ?? ??????? ????? ??? ????????? ?????? ??? 10 ??????? ??? ?????????????. ??? ?????? ??? ?? ????? ?????? ????? ??? ???? ??????????? ??????????, ????? ?? ?????????? ????? ?????????????? [45]. ??????? ????????????? ??????? ????????????? ??? ?? ????? ???? ??? ??????? ????? ????? ????? ??? ??????????? ??? ??? ??????. ??? 26 ????????? ??? ??????? ?????????????, ??????????? (1600 ?? / ???? ????? 2 ?????) ????????? ?????? ???? ????????? ????? ?????? [46]. ??? ??????? ????? ?? ??? ???? ?????? ?????? ????? ?? ????? ?? ???? ??? ??????????? ????? ?? ???????????? ??? ???? ??? ?? ?????????? ??? ??? ???????????. ?? ???????? ??? ?? ????? ??? ????? ????? ???????, ???-?????? ???????, ????? ???????-?????????? ?????? ??????? ????? ???? ????? ???????? ???????????. ?????, ??? ???? ???? ??????? ??? ??? ????? ???? ?????? ???????.

4) ????? ?????

????????????? ????, ???????????? ?????????? ??? ???????????????? ????????? ????? ???????? ?????? ????? ??? ??????. ??????????? ????????? ?? ????? ??? ????????? ???? ??? ?? ???????? ???? ???????????? ?? ?????? ???? ??? ???? ??? ?????????? ??????? ???????????????????. ?????????? ? ????? ??? ???? ?????? ???????, Citicoline (1000mg ?????? ????? 1-3 ?????) ????????? ?????????? ??? ?????????? ? ????? [47,48,49]: ????????? ???????? ??????????? ?????????????? ???? ?????? ?? ??? ????? ?????? ??????? ??? ?????????????? ??????????? (?????????? ??? IL1B) ?????, ?? ???? ??? ??????????? ?????????? ??? ????? ???????. ??? ?? ???? ??????, ????????? ??? ?? ??????? ????????????????? ?? ?????????? ? ????? (APOE-e4 ????????) ??????????????? ????? ??????? ???????. ???? ??? ?? ??????? ????????? ?????? APOE-e4 ???????? ????????? ?????????? (??? ???? ?????) ?? ???????? ??????????????? [48,50]. ??????????? ???????? ?? ???????? ??? ??????? ????????? ????? ?????????? ? ????? ??? ?????? ?? ???????????? ??? ????? ?????????????????? ??????? (??? ??? 600 ?????????) [51,52]. ??? ???? ??? ?????????? ? ?????, ??????????? ????????? ??????? ??? ????????? ??????????? ??? ????????? ???? ??????. ??? ?? ?????????, ?? ???? ????? ?????????? ?????????? ??????????? ??? ????????? ?????? [53]. ??????????? ??? ?????? ?? ?????? ?????????? ? ????? ??? ??????????? ???????? ?????, ????? ????????? ?????? ????? ??? ??????. ???????????? ? ????? ?? ????????? ??? ??????????? ??????? ??? ???????????? ? ????? ? ????? ????????, ??????? ??? ?????? ??????????. ??? ???? ??? ???????????? ? ?????, ??????????? ??????? ????? ???????? ???? ????????? ??????????? ??????? ??? ??? ?????. ?? ???? ????????? ?? ???????? ??? ???????? ???????????? [54,55]. ????? ???????????? ?????????????? ????????? ??? ?? ?????? ???? ??? ?? ???????????? ????? ????? ????? ????? ????? ????????????, ??????? ???? ?????? ?????? ??? ?????????? ???????????. ??? ????????? ??? ????? ????????????, ????????? ????? ??????? ?? ??????????? ??? ??????????? ?? ?????????? ?????? ??????? ??? ??????? ????????????????? [56,57].

5) ???????? ?????????? ??? ??????? ?????????

????????? ??? ?? ?????? ??? 50 ?????????, ?????? ??????????? ?? ??? ???????????????? (??????????????) ????????? ?????????? ?????????? ??? ??????? [58]. ??? ????, CDP-???????? ???????? ???????????????, ??????????? ??? ???????????? ??????? ??? ?? ????? ? ??????, ??????? ??? ?????????? ??????? [59,60]. ???????????????? ??? ???????? ?????? ??????????? ?????? ?????????? ?????????? ??? 60 ???????????????? (????) ??????, ????? ??? ???? ???????? ???? ??????? ???? (2000 ?? / ???? ????? 3 ?????). ??? ?? ????? ?????? ??? 31 ???????????????? ??????, ??????????? ??????????? ??? ????? ??? ?????? ??????? ???? [61,62]. ??? ??? ??? 130 ???????? ?????? ??? ??????????? ?????????, ??????????? (500-2,000 ?? ????? 3 ?????) ?????? ??????? ???? ????? ??? ???? ?????? ???????. ?????, ??? ?? ???????? ??? 20 ????? ???????? ??????, ?? ??? ???? ???????? [63,64,65]. ? ???????? ??? ??????? ??????? ??????? ??? ??????????? ??? ????? ?? ????? ??? ???? ???????? ?????????, ???????? ????????, ????? ????????? ?? ???? ????? ??????? ?????? ????? [66]. ??????????? ???????? ?? ???????? ??? ???????? ???????????? ??? 66 ????????? ??? ??????????????. ?? ????????? ????? ???????? "?????????" ?????????? ????? ??? ??????????? ????????, ????? ????????????? ??? ????????. ?? ???? ??? ?????? ????? ?? ?????? ??? ??????????????? ????? [67]. ??? 24 ?????? ???????, CDP-???????? ????????? ????????? ???? ?????????????? ?? ?????????? ??????????????? ??????????, ????? ??? ???? ????????????? ??? ?????????????? [26]. ????????????? ??????? ????? ????????????, ????? ?? ??? ???? ????? ????? ?? ????? ?? ???? ??? ??????????? ?? ?????? ???????? ?????????? ??? ??????? ?????????.