?na biosynthesis Amino acid kii ?e nikan ?e ipa pataki ninu aw?n i?? igbesi aye, ?ugb?n tun ?e agbega idagbasoke ti i?el?p? amino acid daradara ati ore ayika ati isedale sintetiki ni bakteria ile-i??. Aw?n ?l?j? j? ipil? ti igbesi aye, ati pe w?n ?e ?p?l?p? aw?n ipa ninu aw?n s??li, lati atil?yin igbekal? si aw?n aati kemikali. Gbogbo aw?n ?l?j? j? ti aw?n amino acids ori?iri?i 20 ti a ?ejade ninu aw?n s??li nipas? aw?n ilana biosynthesis eka. Awari ti 20 amino acids ti f?r? to ?g?run ?dun, b?r? p?lu ipinya ak?k? ti glycine nipas? chemist Faranse H. Braconnot ni ?dun 1820, ti o pari p?lu wiwa threonine nipas? W. Rose ni ?dun 1935. Awari ti aw?n amino acids w?nyi p?lu ?p?l?p? aw?n onim?-jinl? ti i?? w?n kii ?e nikan ?e afihan ipil? ati aw?n ohun-ini ti amino acids nigbamii, O tun ?e afihan ipil? ati aw?n ohun-ini ti amino acids nigbamii. iwadi. Biosynthesis ti amino acids j? akoonu ak?k? ti i?el?p? ti i?el?p? makirobia. Nkan yii yoo mu ? l? nipas? bawo ni aw?n amino acids w?nyi ?e ?aj?p? lati aw?n ohun elo ti o r?run ati bii w?n ?e pin w?n. Biosynthesis ti gbogbo aw?n amino acids j? i?el?p? nipas? aw?n ipa ?na eka nipa lilo aw?n agbedemeji ti aw?n ipa ?na i?el?p? aarin bi aw?n i?aju. G?g?bi iru i?aju ib?r?, biosynthesis ti amino acids le pin si aw?n ?gb? 5: aw?n ?gb? Glutamate, p?lu glutamate (Glu), glutamine (Gln), proline (Pro) ati arginine (Arg). Is?p? ti aw?n amino acids w?nyi b?r? p?lu glutamate, moleku b?tini ni ipa ?na i?el?p? aarin. Idile aspartate p?lu aspartate (Asp), aspartamide (Asn), lysine (Lys), threonine (Thr), methionine (Met), ati isoleucine (Ile). I??kan amino acid ti idile yii b?r? p?lu aspartic acid, eyiti o tun j? ?ja ti aw?n ipa ?na i?el?p? aarin. Idile ti aw?n amino acids aromatic, p?lu phenylalanine (Phe), tyrosine (Tyr), ati tryptophan (Trp). I??kan ti aw?n amino acids w?nyi b?r? p?lu erythrosis-4-phosphate (E4P) ati phosphoenolpyruvate (PEP), aw?n ohun elo meji ti o tun j? aw?n agbedemeji pataki ni aw?n ipa ?na i?el?p?. Idile serine p?lu serine (Ser), glycine (Gly), ati cysteine ??(Cys). I??kan amino acid ti idile yii b?r? p?lu serine, eyiti o j? aaye ?ka ti ?p?l?p? aw?n ipa ?na biosynthetic. ?gb? alanine p?lu alanine (Ala), valine (Val) ati leucine (Leu). Botil?j?pe aw?n amino acids w?nyi j? ti aw?n idile ori?iri?i, w?n ni aw?n aati ti o j?ra lakoko i?el?p?, ati pe aw?n aati w?nyi nigbagbogbo j? it?si nipas? kilasi kanna ti aw?n ensaemusi.

Isoleucine, valine, ati leucine, botil?j?pe o j? ti aw?n idile ori?iri?i, ni aw?n aati ti o j?ra nipas? enzymu kanna. Iyipada serine si cysteine ??j? i?esi ak?k? ti idinku sulfate assimilative. Biosynthesis ti ?gb? aromatic amino acid ni ipil??? nipas? erythrosis-4-P ati PEP. Biosynthesis ti histidine j? pataki, ati pe fireemu erogba r? j? lati inu phosphoribose pyrophosphate (PRPP). Aw?n C meji ni ribose ti PRPP ni a lo lati k? oruka imidazole 5-membered, ati aw?n iyokù ni a lo lati ??da ?w?n ?gb? 3C. Biosynthesis ti amino acids ?e ipa pataki ninu bakteria ile-i??. W?n kii ?e paati ipil? nikan ti idagbasoke makirobia ati i?? ?i?e ti i?el?p?, ?ugb?n tun j? ohun elo aise pataki fun ?p?l?p? aw?n ?ja fermented. I?el?p? ti amino acids nipas? bakteria makirobia le ?a?ey?ri daradara ati i?el?p? idiyele kekere lakoko idinku idoti ayika, eyiti o ?e pataki fun ounj?, ifunni, oogun ati aw?n ile-i?? miiran.

Ni afikun, biosynthesis ti amino acids ti ?e igbega idagbasoke ti isedale sintetiki ati im?-?r? ti i?el?p?, ti o j? ki o ?ee ?e lati gbe aw?n amino acid kan pato ati aw?n it?s? w?n nipas? aw?n microorganisms. Eyi kii ?e il?siwaju i?el?p? i?el?p? nikan, ?ugb?n tun pese p?p? kan fun idagbasoke aw?n ?ja im?-?r? tuntun ati siwaju sii gbooro ibiti ohun elo ti bakteria ile-i??.